Patents by Inventor Heike Hofstetter

Heike Hofstetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7217575
    Abstract: A covalent conjugate of a 4?-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH?CH—, wherein n is an integer from 0–10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 15, 2007
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Meir Wilchek, Edward A Bayer, Heike Hofstetter, Margherita Morpurgo
  • Publication number: 20040191832
    Abstract: A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid.
    Type: Application
    Filed: July 23, 2003
    Publication date: September 30, 2004
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo
  • Publication number: 20040067229
    Abstract: A compound of the formula I 1
    Type: Application
    Filed: May 20, 2003
    Publication date: April 8, 2004
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo
  • Patent number: 6632929
    Abstract: A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH═CH—, wherein n is an integer from 0-10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: October 14, 2003
    Assignee: Yeda Research and Development Co. LTD
    Inventors: Meir Wilchek, Edward A Bayer, Heike Hofstetter, Margherita Morpurgo
  • Patent number: 6602987
    Abstract: A compound of the formula I: wherein R is H or —N═N-2-carboxyphenyl; A is (CH2)n or —CH═CH—, wherein n is an integer from 0 to 10, or A may also be —CH(COOH)— when R is —N═N-2-carboxyphenyl; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR1, wherein R1 is p-nitrophenyl or N-succinimidyl; (iii) CONH—NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; (iv) CONH—[B]—NHR3, wherein R3 is H, COOR1, or CO—[B′]—maleimido, wherein R1 is t-butyl, p-nitrophenyl or N-succinimidyl, and B and B′, the same or different, are (CH2)n wherein n is an integer from 2 to 10; (v) CONH—[B]—COOR4, wherein R4 is H, C1-C8 alkyl, N-succinimidyl; (vi) CONH—[B]—OH; (vii) CONH—[B]—CONH—NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; and (viii) NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl, when A is —CH(C
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: August 5, 2003
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo