Abstract: The invention relates to a feeder insert (1, 1?, 1?, 1??, 100, 100?) for use in metal casting in casting molds, comprising a feeder body (2, 2?, 2?, 2??, 102, 102?) which delimits a feeder cavity (4, 4?, 4?, 4??, 104, 104?) for receiving liquid metal, wherein the feeder body (2, 2?, 2?, 2??, 102, 102?) has a first end (6, 6?, 6?, 6??, 106, 106?) having a passage opening (8) for the liquid metal and a second end (10, 10?, 10?, 10??, 110, 110) opposite the first end (6, 6?, 6?, 6??, 106, 106?), and wherein the feeder body (2, 2?, 2?, 2??, 102, 102?) comprises a central axis (Z) extending through the passage opening (8). The feeder body (2, 2?, 2?, 2??, 102, 102?) is separated at least one partition plane (E) extending in a direction of the central axis (Z) and is formed at least from a first feeder shell (18, 18?, 18?, 18??, 118, 118?) and a second feeder shell (20, 20?, 20?, 20??, 120, 120).

Abstract: The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.

Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.

Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.

Abstract: The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The invention relates to a single-piece feeder body for use as a component of a two-part or multi-part telescopic feeder insert in metal casting, having a feeder wall which at least partially delimits a feeder cavity for receiving liquid metal, wherein the feeder wall has a passage opening for the liquid metal into the feeder cavity, and an outer surface on which there are arranged at least one outwardly projecting holding element and at least one guide part with a sliding section for a feeder element which corresponds with the feeder body, wherein the guide part has a supporting section which protrudes outwardly on the outer surface and which, adjoining the sliding section of the guide part for guiding the feeder element, extends in the direction of the passage opening.

Abstract: The invention relates to a method for producing a mold part (26, 26?) with a feeder insert arranged in it, with a sprue for liquid metal, for a divisible casting mold for metal casting, with the following steps: producing or providing a mold part (26, 26?) equipped with a closed feeder insert (2, 2?) from a compacted molding material (28), the closed feeder insert (2, 2?) being arranged fixed in place in the compacted molding material (28) of the mold part (26, 26?) and having a feeder opening (10, 10?) connected to regions of the mold cavity (30, 30?) that is to be formed, and opening the closed feeder insert (2, 2?), so that a sprue (32, 32?) for liquid metal is formed.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The invention relates to an actuator, comprising a drive (2) that drives a drive shaft (1), a first actuating element (3) operatively connected to the drive shaft (1) for actuating a switching apparatus, a spring element (5), which can be supported at one end on a housing component (16) of the actuator and is supported on the other end on a second actuating element (17) designed to load the spring element (5). The actuator according to the invention is characterized in that a rotatably mounted rotational element/gearwheel (13) that can be driven by means of the drive shaft (1) is provided, which rotational element has, on one side, a first control gate (7), which is operatively connected to the first actuating element (3) for actuation of the switching apparatus, and on the other side, a second control gate (8) for loading the spring element (5).

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.

Abstract: The invention relates to a method for producing a mold part (26, 26?) with a feeder insert arranged in it, with a sprue for liquid metal, for a divisible casting mold for metal casting, with the following steps: producing or providing a mold part (26, 26?) equipped with a closed feeder insert (2, 2?) from a compacted molding material (28), the closed feeder insert (2, 2?) being arranged fixed in place in the compacted molding material (28) of the mold part (26, 26?) and having a feeder opening (10, 10?) connected to regions of the mold cavity (30, 30?) that is to be formed, and opening the closed feeder insert (2, 2?), so that a sprue (32, 32?) for liquid metal is formed.

Abstract: The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.

Abstract: The invention relates to a device for detecting the position of a gearshift lever for selecting a gear/driving stage or a gear setting of a motor vehicle. The device has a signal transmitter installed on the gearshift lever and a signal receiver installed at a distance from the signal transmitter, wherein it is possible to detect the different positions of the signal transmitter relative to the signal receiver in different gears or gear settings. The invention further relates to a motor vehicle having such a device.

Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.