Patents by Inventor Heiko Schirmer

Heiko Schirmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220008985
    Abstract: The invention relates to a single-piece feeder body for use as a component of a two-part or multi-part telescopic feeder insert in metal casting, having a feeder wall which at least partially delimits a feeder cavity for receiving liquid metal, wherein the feeder wall has a passage opening for the liquid metal into the feeder cavity, and an outer surface on which there are arranged at least one outwardly projecting holding element and at least one guide part with a sliding section for a feeder element which corresponds with the feeder body, wherein the guide part has a supporting section which protrudes outwardly on the outer surface and which, adjoining the sliding section of the guide part for guiding the feeder element, extends in the direction of the passage opening.
    Type: Application
    Filed: January 9, 2020
    Publication date: January 13, 2022
    Applicant: Chemex Foundry Solutions GmbH
    Inventor: Heiko Schirmer
  • Patent number: 11173151
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 16, 2021
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Marie-Pierre Collin-Kroepelin, Peter Kolkhof, Thomas Neubauer, Chantal Fuerstner, Elisabeth Pook, Matthias Beat Wittwer, Klemens Lustig, Hanna Tinel, Niels Lindner, Heiko Schirmer
  • Patent number: 11173541
    Abstract: The invention relates to a method for producing a mold part (26, 26?) with a feeder insert arranged in it, with a sprue for liquid metal, for a divisible casting mold for metal casting, with the following steps: producing or providing a mold part (26, 26?) equipped with a closed feeder insert (2, 2?) from a compacted molding material (28), the closed feeder insert (2, 2?) being arranged fixed in place in the compacted molding material (28) of the mold part (26, 26?) and having a feeder opening (10, 10?) connected to regions of the mold cavity (30, 30?) that is to be formed, and opening the closed feeder insert (2, 2?), so that a sprue (32, 32?) for liquid metal is formed.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: November 16, 2021
    Assignee: CHEMEX FOUNDRY SOLUTIONS GMBH
    Inventors: Michael Biemel, Heiko Schirmer
  • Patent number: 11149023
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: October 19, 2021
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Marie-Pierre Collin-Kroepelin, Peter Kolkhof, Thomas Neubauer, Chantal Fuerstner, Elisabeth Pook, Matthias Beat Wittwer, Heiko Schirmer, Hanna Tinel
  • Patent number: 11118679
    Abstract: The invention relates to an actuator, comprising a drive (2) that drives a drive shaft (1), a first actuating element (3) operatively connected to the drive shaft (1) for actuating a switching apparatus, a spring element (5), which can be supported at one end on a housing component (16) of the actuator and is supported on the other end on a second actuating element (17) designed to load the spring element (5). The actuator according to the invention is characterized in that a rotatably mounted rotational element/gearwheel (13) that can be driven by means of the drive shaft (1) is provided, which rotational element has, on one side, a first control gate (7), which is operatively connected to the first actuating element (3) for actuation of the switching apparatus, and on the other side, a second control gate (8) for loading the spring element (5).
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: September 14, 2021
    Assignee: Küster Holding GmbH
    Inventors: Martin Blücher, Thomas Schmidt, Heiko Schirmer, Bernd Junker
  • Publication number: 20210253557
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: August 19, 2021
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Hanna TINEL, Carsten SCHMECK, Pierre WASNAIRE, Heiko SCHIRMER, Klemens LUSTIG, Nils GRIEBENOW
  • Patent number: 11091463
    Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: August 17, 2021
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Marie-Pierre Collin, Peter Kolkhof, Thomas Neubauer, Chantal Fuerstner, Elisabeth Pook, Matthias Beat Wittwer, Klemens Lustig, Anja Buchmueller, Hanna Tinel, Karoline Droebner, Thomas Mondritzki, Heiko Schirmer, Axel Kretschmer, Carsten Schmeck, Pierre Wasnaire, Hana Cernecka
  • Publication number: 20210179590
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: June 17, 2021
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Hanna TINEL, Carsten SCHMECK, Pierre WASNAIRE, Heiko SCHIRMER, Klemens LUSTIG
  • Publication number: 20210113504
    Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 22, 2021
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Anke Stroyer, Carmen Lobback, Peter Serno, Philipp Rubenbauer, Kai Lovis, Heiko Schirmer, Danja Grossbach, Donald Bierer, Britta Olenik, Tia Jacobs, Julia Küsel
  • Publication number: 20210086256
    Abstract: The invention relates to a method for producing a mold part (26, 26?) with a feeder insert arranged in it, with a sprue for liquid metal, for a divisible casting mold for metal casting, with the following steps: producing or providing a mold part (26, 26?) equipped with a closed feeder insert (2, 2?) from a compacted molding material (28), the closed feeder insert (2, 2?) being arranged fixed in place in the compacted molding material (28) of the mold part (26, 26?) and having a feeder opening (10, 10?) connected to regions of the mold cavity (30, 30?) that is to be formed, and opening the closed feeder insert (2, 2?), so that a sprue (32, 32?) for liquid metal is formed.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 25, 2021
    Applicant: Chemex Foundry Solutions GmbH
    Inventors: Michael Biemel, Heiko Schirmer
  • Patent number: 10927948
    Abstract: The invention relates to a device for detecting the position of a gearshift lever for selecting a gear/driving stage or a gear setting of a motor vehicle. The device has a signal transmitter installed on the gearshift lever and a signal receiver installed at a distance from the signal transmitter, wherein it is possible to detect the different positions of the signal transmitter relative to the signal receiver in different gears or gear settings. The invention further relates to a motor vehicle having such a device.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: February 23, 2021
    Assignee: KÜSTER HOLDING GMBH
    Inventors: Joachim Brück, Michael Nicodemus, Tobias Eichenauer, Heiko Schirmer, Wolfgang Pätzold, Evelyn Vorländer, Viktor Kremer
  • Patent number: 10927098
    Abstract: The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: February 23, 2021
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Chantal Fuerstner, Marie-Pierre Collin-Kroepelin, Peter Kolkhof, Thomas Neubauer, Elisabeth Pook, Heiko Schirmer, Carsten Schmeck, Pierre Wasnaire, Matthias Beat Wittwer
  • Patent number: 10905667
    Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: February 2, 2021
    Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Anke Stroyer, Carmen Lobback, Peter Serno, Philipp Rubenbauer, Kai Lovis, Heiko Schirmer, Danja Grossbach, Donald Bierer, Britta Olenik, Tia Jacobs, Julia Küsel
  • Publication number: 20200338096
    Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: October 29, 2020
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Matthias Beat WITTWER, Carsten SCHMECK, Pierre WASNAIRE, Heiko SCHIRMER, Hana CERNECKA, Karoline DROEBNER, Hanna TINEL, Anja BUCHMUELLER, Thomas MONDRITZKI, Axel KRETSCHMER, Klemens LUSTIG, Robert FRICKE, Guillaume LEVILAIN, Ursula KRENZ, Norbert WITOWSKI
  • Patent number: 10815205
    Abstract: The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: October 27, 2020
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Marie-Pierre Collin-Kröpelin, Peter Kolkhof, Thomas Neubauer, Chantal Fürstner, Elisabeth Pook, Matthias Beat Wittwer, Klemens Lustig, Anja Buchmüller, Hanna Tinel, Karoline Dröbner, Thomas Mondritzki, Heiko Schirmer, Axel Kretschmer, Carsten Schmeck, Pierre Wasnaire, Hana Cernecka
  • Publication number: 20200316045
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: October 8, 2020
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Matthias Beat WITTWER, Klemens LUSTIG, Hanna TINEL, Niels LINDNER, Heiko SCHIRMER
  • Publication number: 20200299271
    Abstract: The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R1A and R1B are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of (5-(4-chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
    Type: Application
    Filed: May 21, 2020
    Publication date: September 24, 2020
    Inventors: Heiko SCHIRMER, Philipp RUBENBAUER, Hans-Christian MILITZER, Marie-Pierre COLLIN-KROEPELIN, Frank SUESSMEIER, Kersten GERICKE, Thomas NEUBAUER, Chantal FUERSTNER
  • Publication number: 20200253961
    Abstract: The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: August 13, 2020
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Hanna TINEL, Carsten SCHMECK, Pierre WASNAIRE, Heiko SCHIRMER, Klemens LUSTIG
  • Publication number: 20200255402
    Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
    Type: Application
    Filed: October 17, 2018
    Publication date: August 13, 2020
    Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Matthias Beat WITTWER, Heiko SCHIRMER, Hanna TINEL
  • Patent number: 10703727
    Abstract: The present invention relates to a method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives of the general formula (I) in which R1 represents a hydrogen atom or R1 represents a group selected from the series of C1-C3-alkyl-, C1-C3-alkoxy-, C1-C3-haloalkyl- and C1-C3-haloalkoxy-, R2 represents a hydrogen atom or a C1-C3-alkyl group, R3 represents a hydrogen atom or a C1-C3-alkyl group, R4 represents a cyclohexyl group, which is optionally singly or multiply substituted by a C1-C3-alkyl group, and R5 represents a hydrogen atom or a C1-C6-alkyl group; and also intermediates which may be used to prepare substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: July 7, 2020
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventor: Heiko Schirmer