Patents by Inventor Helen Chen

Helen Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION
    Publication number: 20070128695
    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
    Type: Application
    Filed: September 30, 2006
    Publication date: June 7, 2007
    Applicant: Genentech,Inc.
    Inventors: Terri Davis-Smyth, Helen Chen, Leonard Presta, Napoleone Ferrara
  • Novel inhibitors of vascular endothelial growth factor activity, their uses and processes for their production
    Publication number: 20050281831
    Abstract: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
    Type: Application
    Filed: January 26, 2005
    Publication date: December 22, 2005
    Applicant: Genentech, Inc.
    Inventors: Terri Davis-Smyth, Helen Chen, Leonard Presta, Napoleone Ferrara
  • Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
    Patent number: 6277843
    Abstract: The present invention relates to carbapenem antibacterial agents of the formula I: as well as salts and hydrates thereof. Pharmaceutical compositions and methods of treatment are also included wherein X is present or absent, when present, represents a members selected from the group consisting of: CH2, C(R)2, C═CR2, O, S(O)x, with x equal to 0, 1 or 2; C(O), C(O)O, OC(O) and NR—.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: August 21, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. Dininno, Helen Chen
  • LTA4 hydrolase inhibitors
    Patent number: 6265433
    Abstract: The present invention provides compounds having the structure: and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: July 24, 2001
    Assignee: G. D. Searle & Company
    Inventors: Barbara Baosheng Chen, Helen Chen, Mark Andrew Russell, Julie Marion Miyashiro, James Malecha, Thomas Dale Penning
  • LTA.sub.4, hydrolase inhibitors
    Patent number: 6110944
    Abstract: The present invention provides compounds having the structureAr.sub.1 --Q--Ar.sub.2 --O--(CH.sub.2).sub.n --Zand pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: August 29, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Barbara Baosheng Chen, Helen Chen, Mark Andrew Russell
  • LTA.sub.4 , hydrolase inhibitors
    Patent number: 5925654
    Abstract: The present invention provides compounds having the structure: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: July 20, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Barbara Baosheng Chen, Helen Chen, Mark Andrew Russell, Julie Marion Miyashiro, James Malecha, Thomas Dale Penning
  • Culinary scissors
    Patent number: D329792
    Type: Grant
    Filed: August 1, 1990
    Date of Patent: September 29, 1992
    Inventor: Helen Chen