Patents by Inventor Helen Liu
Helen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240076720Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.Type: ApplicationFiled: February 9, 2023Publication date: March 7, 2024Inventors: Shankar BALASUBRAMANIAN, Jens FULLGRABE, Walraj Singh GOSAL, Joanna Dawn HOLBROOK, Sidong LIU, David MORLEY, Oliver NENTWICH, Tobias OST, Michael STEWARD, Albert VILELLA, Nicolas James WALKER, Shirong YU, Helen Rachel BIGNELL, Rita Santo SAN-BENTO
-
Publication number: 20230346935Abstract: A tumor complex antigen, a multivalent dendritic cell (DC) vaccine, and a use thereof are provided. In the present disclosure, monocytes of a patient are stimulated in vitro, loaded with a variety of tumor cell lysates with strong immunogenicity against different Epstein-Barr virus (EBV)-associated tumors, and induced into mature dendritic cells (mDCs) by various cytokines and specific agonists to obtain a complete DC vaccine with corresponding tumor antigens. The DC vaccine can be injected back into the patient to activate an immune system, stimulate innate immunity (such as inducing natural killer (NK) cells), and stimulate lymphocytes to produce an acquired immune response and cytotoxic T cells, thereby accurately killing tumor cells. Compared with radiotherapy and chemotherapy, the DC vaccine is particularly safe and has almost no side effects. In addition, the production of the DC vaccine involves a short production cycle of about 1 week and a low cost.Type: ApplicationFiled: August 4, 2021Publication date: November 2, 2023Applicants: KOUSAI Bio Co., LtdInventors: Helen LIU, Ze YIN
-
Patent number: 11629952Abstract: Systems and methods for unwrapping a phase map are disclosed. Such systems and methods may include receiving a wrapped phase map associated with an interferometric measurement of a sample including patterned features; removing a tilt from the wrapped phase map; generating a background; detecting features in the wrapped phase, the features in the wrapped phase map corresponding to least some of the patterned features of the sample; replacing phases of the features with the background at corresponding locations in the wrapped phase map; unwrapping the modified wrapped phase map using a global phase-unwrapping; applying local phase-unwrapping to restore the phases of the features; and reapplying the tilt to generate an output unwrapped phase map.Type: GrantFiled: May 26, 2022Date of Patent: April 18, 2023Assignee: KLA CorporationInventors: Helen Liu, Guoqing Zhang, Hui Li
-
Publication number: 20220390862Abstract: Systems and methods for unwrapping a phase map are disclosed. Such systems and methods may include receiving a wrapped phase map associated with an interferometric measurement of a sample including patterned features; removing a tilt from the wrapped phase map; generating a background; detecting features in the wrapped phase, the features in the wrapped phase map corresponding to least some of the patterned features of the sample; replacing phases of the features with the background at corresponding locations in the wrapped phase map; unwrapping the modified wrapped phase map using a global phase-unwrapping; applying local phase-unwrapping to restore the phases of the features; and reapplying the tilt to generate an output unwrapped phase map.Type: ApplicationFiled: May 26, 2022Publication date: December 8, 2022Applicants: KLA Corporation, KLA CorporationInventors: Helen Liu, Guoqing Zhang, Hui Li
-
Publication number: 20210065993Abstract: Hybrid electrochemical cells and modules include an anode two-sided current collector a coated with host material in anode region(s) and a cathode two-sided current collector coated with active material in cathode region(s), and one or more of the anode current collector and the cathode current collector is coated with capacitor material in one or more distinct, non-overlapping capacitor regions. A hybrid anode and/or cathode can include gaps between capacitor regions and anode regions and cathode regions. The capacitor material applied to an electrode is different from the host or active material thereof. Active material includes lithium metal oxides and lithium metal phosphates such as LiFePO4, Li(NixMnyCoz)O2, and/or LiMn2O4; host material includes graphite, silicon, silicon-Li/Sn/Cu alloys, Si/Co/Fe/TiSn oxides, and low-surface area carbon; and capacitor material includes activated carbon, metal oxides, and metal sulfides.Type: ApplicationFiled: April 23, 2018Publication date: March 4, 2021Inventors: Helen Liu, Xiaochao Que, Dewen Kong, Jianfeng Wang
-
Patent number: 10659440Abstract: Certain embodiments described herein are generally directed to methods and apparatus for providing a security parameter index (SPI) value for use in establishing a security association between a source tunnel endpoint and a destination tunnel endpoint. In some embodiments, utilization of the SPI bit space is optimized to allow the scaling of key policies within a network. In some embodiment, using an SPI derivation formula, a server in the network is able to generate SPI values whose bit spaces are optimized to allow key policies to scale out.Type: GrantFiled: November 30, 2017Date of Patent: May 19, 2020Assignee: Nicira, Inc.Inventors: Dexiang Wang, Zhen Mo, Fang Peng, Bo Hu, Helen Liu
-
Patent number: 10629760Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.Type: GrantFiled: May 22, 2017Date of Patent: April 21, 2020Assignee: SunPower CorporationInventors: David D. Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez
-
Patent number: 10571248Abstract: A system includes one or more wafer geometry measurement tools configured to obtain geometry measurements from a wafer. The system also includes one or more processors in communication with the one or more wafer geometry measurement tools. The one or more processors are configured to apply a correction model to correct the geometry measurements obtained by the one or more wafer geometry measurement tools. The correction model is configured to correct measurement errors caused by a transparent film positioned on the wafer.Type: GrantFiled: July 13, 2017Date of Patent: February 25, 2020Assignee: KLA-Tencor CorporationInventors: Helen Liu, Andrew Zeng
-
Publication number: 20190166109Abstract: Certain embodiments described herein are generally directed to methods and apparatus for providing a security parameter index (SPI) value for use in establishing a security association between a source tunnel endpoint and a destination tunnel endpoint. In some embodiments, utilization of the SPI bit space is optimized to allow the scaling of key policies within a network. In some embodiment, using an SPI derivation formula, a server in the network is able to generate SPI values whose bit spaces are optimized to allow key policies to scale out.Type: ApplicationFiled: November 30, 2017Publication date: May 30, 2019Inventors: Dexiang WANG, Zhen MO, Fang PENG, Bo HU, Helen LIU
-
Patent number: 10237205Abstract: A method using a computer in conjunction with a non-transitory computer readable storage medium is provided comprising a computer receiving a message for forwarding at an ingress switch of a multi-stage circuit switching network. The method also comprises computer executing a first routing algorithm in transmitting the message, the algorithm comprising the computer determining at least one availability matrix for each middle switch, wherein a given middle switch comprises a switch between ingress and egress switches of the network. The method also comprises the computer assigning resources to a selected middle switch and updating the availability matrix and causing the ingress switch to transmit the message via the middle switch based on determining a first availability matrix for the middle switch using the algorithm wherein the algorithm is executed to forward messages on at least one of unicast, fan-in, and fan-out bases and minimize blocking and imbalance on middle switches.Type: GrantFiled: June 20, 2013Date of Patent: March 19, 2019Assignee: The Boeing CompanyInventors: Kristina A. Miller, Tu Q. Le, Tae J. Roh, Helen Liu
-
Patent number: 10217190Abstract: A method for reconstructing one or more high-resolution point spread functions (PSF) from one or more low-resolution images includes acquiring one or more low-resolution images of a wafer, aggregating the one or more low-resolution image patches, and estimating one or more sub-pixel shifts in the one or more low-resolution images and simultaneously reconstructing one or more high-resolution PSF from the aggregated one or more low-resolution image patches.Type: GrantFiled: December 27, 2016Date of Patent: February 26, 2019Assignee: KLA-Tencor CorporationInventors: Helen Liu, Rohit Patnaik, Stephen Osborne
-
Publication number: 20190044097Abstract: Some lithium-ion batteries are assembled using a plurality of electrically interconnected battery pouches to obtain the electrical potential and power requirements of the battery application. Such battery pouches may be prepared to contain a stacked grouping, or a wound grouping, of inter-layered and interconnected anodes, cathodes, and separators, each wetted with a liquid electrolyte. A reference electrode, an optional auxiliary reference electrode, and adjacent enclosing modified working electrodes are combined in a specific arrangement and inserted within the stack structure, or the wound structure, of other cell members to enable accurate assessment of both anode group and cathode group performance, and to validate and regenerate reference electrode capability.Type: ApplicationFiled: March 18, 2016Publication date: February 7, 2019Inventors: Zhiqiang Yu, Samson Wu, Xiaochao Que, Helen Liu
-
Publication number: 20180195855Abstract: A system includes one or more wafer geometry measurement tools configured to obtain geometry measurements from a wafer. The system also includes one or more processors in communication with the one or more wafer geometry measurement tools. The one or more processors are configured to apply a correction model to correct the geometry measurements obtained by the one or more wafer geometry measurement tools. The correction model is configured to correct measurement errors caused by a transparent film positioned on the wafer.Type: ApplicationFiled: July 13, 2017Publication date: July 12, 2018Inventors: Helen Liu, Andrew Zeng
-
Publication number: 20180182067Abstract: A method for reconstructing one or more high-resolution point spread functions (PSF) from one or more low-resolution images includes acquiring one or more low-resolution images of a wafer, aggregating the one or more low-resolution image patches, and estimating one or more sub-pixel shifts in the one or more low-resolution images and simultaneously reconstructing one or more high-resolution PSF from the aggregated one or more low-resolution image patches.Type: ApplicationFiled: December 27, 2016Publication date: June 28, 2018Inventors: Helen Liu, Rohit Patnaik, Stephen Osborne
-
Publication number: 20180175373Abstract: A system for forming an electrode for a lithium-ion battery cell includes an electrode material, a material-supply mechanism, a wetting mechanism, a debris-generating tool, and a conditioner. The material-supply mechanism is configured to deliver the electrode material. The wetting mechanism is configured to receive the electrode material from the material-supply mechanism and apply a solution to the electrode material to produce a wet precursor. The debris-generating tool is configured to remove a portion of the electrode material from the wet precursor to form a pre-electrode. The conditioner is configured to eliminate the solution from the pre-electrode and thereby form the electrode.Type: ApplicationFiled: December 19, 2016Publication date: June 21, 2018Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Sherman H. Zeng, Zhiqiang Yu, Dewen Kong, Helen Liu
-
Patent number: 9897433Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.Type: GrantFiled: December 28, 2015Date of Patent: February 20, 2018Assignee: KLA—Tencor CorporationInventors: Helen Liu, Xuan Zhao, Xiaowei Li
-
Publication number: 20170263795Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.Type: ApplicationFiled: May 22, 2017Publication date: September 14, 2017Inventors: David D. Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez
-
Publication number: 20170241764Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.Type: ApplicationFiled: December 28, 2015Publication date: August 24, 2017Inventors: Helen Liu, Xuan Zhao, Xiaowei Li
-
Publication number: 20140376546Abstract: A method using a computer in conjunction with a non-transitory computer readable storage medium is provided comprising a computer receiving a message for forwarding at an ingress switch of a multi-stage circuit switching network. The method also comprises computer executing a first routing algorithm in transmitting the message, the algorithm comprising the computer determining at least one availability matrix for each middle switch, wherein a given middle switch comprises a switch between ingress and egress switches of the network. The method also comprises the computer assigning resources to a selected middle switch and updating the availability matrix and causing the ingress switch to transmit the message via the middle switch based on determining a first availability matrix for the middle switch using the algorithm wherein the algorithm is executed to forward messages on at least one of unicast, fan-in, and fan-out bases and minimize blocking and imbalance on middle switches.Type: ApplicationFiled: June 20, 2013Publication date: December 25, 2014Inventors: Kristina A. Miller, Tu Q. Le, Tae J. Roh, Helen Liu
-
Publication number: 20120073650Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.Type: ApplicationFiled: September 24, 2010Publication date: March 29, 2012Inventors: David Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez