Patents by Inventor Helen Liu

Helen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240076720
    Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.
    Type: Application
    Filed: February 9, 2023
    Publication date: March 7, 2024
    Inventors: Shankar BALASUBRAMANIAN, Jens FULLGRABE, Walraj Singh GOSAL, Joanna Dawn HOLBROOK, Sidong LIU, David MORLEY, Oliver NENTWICH, Tobias OST, Michael STEWARD, Albert VILELLA, Nicolas James WALKER, Shirong YU, Helen Rachel BIGNELL, Rita Santo SAN-BENTO
  • Publication number: 20230346935
    Abstract: A tumor complex antigen, a multivalent dendritic cell (DC) vaccine, and a use thereof are provided. In the present disclosure, monocytes of a patient are stimulated in vitro, loaded with a variety of tumor cell lysates with strong immunogenicity against different Epstein-Barr virus (EBV)-associated tumors, and induced into mature dendritic cells (mDCs) by various cytokines and specific agonists to obtain a complete DC vaccine with corresponding tumor antigens. The DC vaccine can be injected back into the patient to activate an immune system, stimulate innate immunity (such as inducing natural killer (NK) cells), and stimulate lymphocytes to produce an acquired immune response and cytotoxic T cells, thereby accurately killing tumor cells. Compared with radiotherapy and chemotherapy, the DC vaccine is particularly safe and has almost no side effects. In addition, the production of the DC vaccine involves a short production cycle of about 1 week and a low cost.
    Type: Application
    Filed: August 4, 2021
    Publication date: November 2, 2023
    Applicants: KOUSAI Bio Co., Ltd
    Inventors: Helen LIU, Ze YIN
  • Patent number: 11629952
    Abstract: Systems and methods for unwrapping a phase map are disclosed. Such systems and methods may include receiving a wrapped phase map associated with an interferometric measurement of a sample including patterned features; removing a tilt from the wrapped phase map; generating a background; detecting features in the wrapped phase, the features in the wrapped phase map corresponding to least some of the patterned features of the sample; replacing phases of the features with the background at corresponding locations in the wrapped phase map; unwrapping the modified wrapped phase map using a global phase-unwrapping; applying local phase-unwrapping to restore the phases of the features; and reapplying the tilt to generate an output unwrapped phase map.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: April 18, 2023
    Assignee: KLA Corporation
    Inventors: Helen Liu, Guoqing Zhang, Hui Li
  • Publication number: 20220390862
    Abstract: Systems and methods for unwrapping a phase map are disclosed. Such systems and methods may include receiving a wrapped phase map associated with an interferometric measurement of a sample including patterned features; removing a tilt from the wrapped phase map; generating a background; detecting features in the wrapped phase, the features in the wrapped phase map corresponding to least some of the patterned features of the sample; replacing phases of the features with the background at corresponding locations in the wrapped phase map; unwrapping the modified wrapped phase map using a global phase-unwrapping; applying local phase-unwrapping to restore the phases of the features; and reapplying the tilt to generate an output unwrapped phase map.
    Type: Application
    Filed: May 26, 2022
    Publication date: December 8, 2022
    Applicants: KLA Corporation, KLA Corporation
    Inventors: Helen Liu, Guoqing Zhang, Hui Li
  • Publication number: 20210065993
    Abstract: Hybrid electrochemical cells and modules include an anode two-sided current collector a coated with host material in anode region(s) and a cathode two-sided current collector coated with active material in cathode region(s), and one or more of the anode current collector and the cathode current collector is coated with capacitor material in one or more distinct, non-overlapping capacitor regions. A hybrid anode and/or cathode can include gaps between capacitor regions and anode regions and cathode regions. The capacitor material applied to an electrode is different from the host or active material thereof. Active material includes lithium metal oxides and lithium metal phosphates such as LiFePO4, Li(NixMnyCoz)O2, and/or LiMn2O4; host material includes graphite, silicon, silicon-Li/Sn/Cu alloys, Si/Co/Fe/TiSn oxides, and low-surface area carbon; and capacitor material includes activated carbon, metal oxides, and metal sulfides.
    Type: Application
    Filed: April 23, 2018
    Publication date: March 4, 2021
    Inventors: Helen Liu, Xiaochao Que, Dewen Kong, Jianfeng Wang
  • Patent number: 10659440
    Abstract: Certain embodiments described herein are generally directed to methods and apparatus for providing a security parameter index (SPI) value for use in establishing a security association between a source tunnel endpoint and a destination tunnel endpoint. In some embodiments, utilization of the SPI bit space is optimized to allow the scaling of key policies within a network. In some embodiment, using an SPI derivation formula, a server in the network is able to generate SPI values whose bit spaces are optimized to allow key policies to scale out.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 19, 2020
    Assignee: Nicira, Inc.
    Inventors: Dexiang Wang, Zhen Mo, Fang Peng, Bo Hu, Helen Liu
  • Patent number: 10629760
    Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: April 21, 2020
    Assignee: SunPower Corporation
    Inventors: David D. Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez
  • Patent number: 10571248
    Abstract: A system includes one or more wafer geometry measurement tools configured to obtain geometry measurements from a wafer. The system also includes one or more processors in communication with the one or more wafer geometry measurement tools. The one or more processors are configured to apply a correction model to correct the geometry measurements obtained by the one or more wafer geometry measurement tools. The correction model is configured to correct measurement errors caused by a transparent film positioned on the wafer.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: February 25, 2020
    Assignee: KLA-Tencor Corporation
    Inventors: Helen Liu, Andrew Zeng
  • Publication number: 20190166109
    Abstract: Certain embodiments described herein are generally directed to methods and apparatus for providing a security parameter index (SPI) value for use in establishing a security association between a source tunnel endpoint and a destination tunnel endpoint. In some embodiments, utilization of the SPI bit space is optimized to allow the scaling of key policies within a network. In some embodiment, using an SPI derivation formula, a server in the network is able to generate SPI values whose bit spaces are optimized to allow key policies to scale out.
    Type: Application
    Filed: November 30, 2017
    Publication date: May 30, 2019
    Inventors: Dexiang WANG, Zhen MO, Fang PENG, Bo HU, Helen LIU
  • Patent number: 10237205
    Abstract: A method using a computer in conjunction with a non-transitory computer readable storage medium is provided comprising a computer receiving a message for forwarding at an ingress switch of a multi-stage circuit switching network. The method also comprises computer executing a first routing algorithm in transmitting the message, the algorithm comprising the computer determining at least one availability matrix for each middle switch, wherein a given middle switch comprises a switch between ingress and egress switches of the network. The method also comprises the computer assigning resources to a selected middle switch and updating the availability matrix and causing the ingress switch to transmit the message via the middle switch based on determining a first availability matrix for the middle switch using the algorithm wherein the algorithm is executed to forward messages on at least one of unicast, fan-in, and fan-out bases and minimize blocking and imbalance on middle switches.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: March 19, 2019
    Assignee: The Boeing Company
    Inventors: Kristina A. Miller, Tu Q. Le, Tae J. Roh, Helen Liu
  • Patent number: 10217190
    Abstract: A method for reconstructing one or more high-resolution point spread functions (PSF) from one or more low-resolution images includes acquiring one or more low-resolution images of a wafer, aggregating the one or more low-resolution image patches, and estimating one or more sub-pixel shifts in the one or more low-resolution images and simultaneously reconstructing one or more high-resolution PSF from the aggregated one or more low-resolution image patches.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: February 26, 2019
    Assignee: KLA-Tencor Corporation
    Inventors: Helen Liu, Rohit Patnaik, Stephen Osborne
  • Publication number: 20190044097
    Abstract: Some lithium-ion batteries are assembled using a plurality of electrically interconnected battery pouches to obtain the electrical potential and power requirements of the battery application. Such battery pouches may be prepared to contain a stacked grouping, or a wound grouping, of inter-layered and interconnected anodes, cathodes, and separators, each wetted with a liquid electrolyte. A reference electrode, an optional auxiliary reference electrode, and adjacent enclosing modified working electrodes are combined in a specific arrangement and inserted within the stack structure, or the wound structure, of other cell members to enable accurate assessment of both anode group and cathode group performance, and to validate and regenerate reference electrode capability.
    Type: Application
    Filed: March 18, 2016
    Publication date: February 7, 2019
    Inventors: Zhiqiang Yu, Samson Wu, Xiaochao Que, Helen Liu
  • Publication number: 20180195855
    Abstract: A system includes one or more wafer geometry measurement tools configured to obtain geometry measurements from a wafer. The system also includes one or more processors in communication with the one or more wafer geometry measurement tools. The one or more processors are configured to apply a correction model to correct the geometry measurements obtained by the one or more wafer geometry measurement tools. The correction model is configured to correct measurement errors caused by a transparent film positioned on the wafer.
    Type: Application
    Filed: July 13, 2017
    Publication date: July 12, 2018
    Inventors: Helen Liu, Andrew Zeng
  • Publication number: 20180182067
    Abstract: A method for reconstructing one or more high-resolution point spread functions (PSF) from one or more low-resolution images includes acquiring one or more low-resolution images of a wafer, aggregating the one or more low-resolution image patches, and estimating one or more sub-pixel shifts in the one or more low-resolution images and simultaneously reconstructing one or more high-resolution PSF from the aggregated one or more low-resolution image patches.
    Type: Application
    Filed: December 27, 2016
    Publication date: June 28, 2018
    Inventors: Helen Liu, Rohit Patnaik, Stephen Osborne
  • Publication number: 20180175373
    Abstract: A system for forming an electrode for a lithium-ion battery cell includes an electrode material, a material-supply mechanism, a wetting mechanism, a debris-generating tool, and a conditioner. The material-supply mechanism is configured to deliver the electrode material. The wetting mechanism is configured to receive the electrode material from the material-supply mechanism and apply a solution to the electrode material to produce a wet precursor. The debris-generating tool is configured to remove a portion of the electrode material from the wet precursor to form a pre-electrode. The conditioner is configured to eliminate the solution from the pre-electrode and thereby form the electrode.
    Type: Application
    Filed: December 19, 2016
    Publication date: June 21, 2018
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Sherman H. Zeng, Zhiqiang Yu, Dewen Kong, Helen Liu
  • Patent number: 9897433
    Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: February 20, 2018
    Assignee: KLA—Tencor Corporation
    Inventors: Helen Liu, Xuan Zhao, Xiaowei Li
  • Publication number: 20170263795
    Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.
    Type: Application
    Filed: May 22, 2017
    Publication date: September 14, 2017
    Inventors: David D. Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez
  • Publication number: 20170241764
    Abstract: A wafer metrology system includes an interferometer sub-system and a controller. The interferometer sub-system is configured to generate an interferogram with an intensity map that corresponds to a modulated representation of a wafer surface. Further, the interferometer sub-system includes a detector configured to capture the interferogram. The controller includes one or more processors configured to generate a wrapped phase map of the interferogram, define patterns associated with features on the wafer, and correct phase discontinuities by applying a phase unwrapping procedure to the wrapped phase map to generate an unwrapped phase map and correcting phase discontinuities in the unwrapped phase map based on the patterns, or by combining phase unwrapping and correction in a unified step. Further, the patterns comprise two or more structures such that a portion of the unwrapped phase map associated with structures of the same type is continuous across borders separating structures of the same type.
    Type: Application
    Filed: December 28, 2015
    Publication date: August 24, 2017
    Inventors: Helen Liu, Xuan Zhao, Xiaowei Li
  • Publication number: 20140376546
    Abstract: A method using a computer in conjunction with a non-transitory computer readable storage medium is provided comprising a computer receiving a message for forwarding at an ingress switch of a multi-stage circuit switching network. The method also comprises computer executing a first routing algorithm in transmitting the message, the algorithm comprising the computer determining at least one availability matrix for each middle switch, wherein a given middle switch comprises a switch between ingress and egress switches of the network. The method also comprises the computer assigning resources to a selected middle switch and updating the availability matrix and causing the ingress switch to transmit the message via the middle switch based on determining a first availability matrix for the middle switch using the algorithm wherein the algorithm is executed to forward messages on at least one of unicast, fan-in, and fan-out bases and minimize blocking and imbalance on middle switches.
    Type: Application
    Filed: June 20, 2013
    Publication date: December 25, 2014
    Inventors: Kristina A. Miller, Tu Q. Le, Tae J. Roh, Helen Liu
  • Publication number: 20120073650
    Abstract: Methods of fabricating emitter regions of solar cells are described. Methods of forming layers on substrates of solar cells, and the resulting solar cells, are also described.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 29, 2012
    Inventors: David Smith, Helen Liu, Tim Dennis, Jane Manning, Hsin-Chiao Luan, Ann Waldhauer, Genevieve A. Solomon, Brenda Pagulayan Malgapu, Joseph Ramirez