Patents by Inventor Helen M. Organ

Helen M. Organ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
    Patent number: 5880280
    Abstract: Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by modification at C-30, C-33, and/or C-34 of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: March 9, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Helen M. Organ, Mark A. Holmes
  • O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
    Patent number: 5693648
    Abstract: Substituted compounds of the FK-506 Type. These compounds are useful for the same or essentially the same purposes as FK-506 and are applied in the same or a similar manner. These compounds are immunosuppressants and useful for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. Still other uses are described in the disclosure.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: December 2, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Helen M. Organ, William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
    Patent number: 5565560
    Abstract: O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: October 15, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Helen M. Organ, William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity
    Patent number: 5532248
    Abstract: O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: July 2, 1996
    Assignee: Merck Co., Inc.
    Inventors: Mark Goulet, William H. Parsons, Helen M. Organ, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • Alkyl and alkenyl macrolides having immunosuppressive activity
    Patent number: 5284877
    Abstract: Alkyl and alkenyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and derivitization at C-17. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: February 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Helen M. Organ, Mark A. Holmes, Judith M. Pisano, Matthew J. Wyvratt
  • Amino O-aryl macrolides having immunosuppressive activity
    Patent number: 5262533
    Abstract: Amino O-aryl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by arylation and amination at C-3"/C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses.
    Type: Grant
    Filed: May 6, 1992
    Date of Patent: November 16, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Sinclair, Helen M. Organ, Matthew J. Wyvratt