Patents by Inventor Helene Faustrup KILDEGAARD

Helene Faustrup KILDEGAARD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCOSYLATION OF PROTEINS
    Publication number: 20230272445
    Abstract: The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.
    Type: Application
    Filed: November 16, 2022
    Publication date: August 31, 2023
    Inventors: Bjørn Gunnar Voldborg, Stefan Kol, Anders Holmgaard Hansen, Helene Faustrup Kildegaard
  • Glycosylation of proteins
    Patent number: 11624080
    Abstract: The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced semm glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: April 11, 2023
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Bjørn Gunnar Voldborg, Stefan Kol, Anders Holmgaard Hansen, Helene Faustrup Kildegaard
  • Asparaginase Based Selection System for Heterologous Protein Expression in Mammalian Cells
    Publication number: 20220356488
    Abstract: A non-naturally occurring cell comprising an inoperative genomic asparaginase (Aspg) gene and an inoperative glutamine synthetase (Gs) gene, wherein the cell has been transfected with a controllably expressed gene encoding an enzyme having asparaginase activity, a controllably expressed gene encoding an enzyme having glutamine synthetase activity, and a controllably expressed gene encoding a heterologous protein of interest.
    Type: Application
    Filed: May 6, 2022
    Publication date: November 10, 2022
    Inventors: Hooman Hefzi, Nathan E. Lewis, Karen Julie la Cour Karottki, Helene Faustrup Kildegaard
  • GLYCOSYLATION OF PROTEINS
    Publication number: 20210262000
    Abstract: The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced semm glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.
    Type: Application
    Filed: November 16, 2018
    Publication date: August 26, 2021
    Inventors: Bjørn Gunnar Voldborg, Stefan Kol, Anders Holmgaard Hansen, Helene Faustrup Kildegaard
  • Method for reducing ammonium and lactate production in CHO cells
    Patent number: 10961556
    Abstract: The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: March 30, 2021
    Assignee: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Daniel Ley, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
  • METHOD FOR REDUCING AMMONIUM AND LACTATE PRODUCTION IN CHO CELLS
    Publication number: 20190203249
    Abstract: The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.
    Type: Application
    Filed: August 15, 2017
    Publication date: July 4, 2019
    Inventors: Daniel LEY, Mikael Rørdam ANDERSEN, Helene Faustrup KILDEGAARD