Patents by Inventor Helle NYMARK

Helle NYMARK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTISENSE OLIGONUCLEOTIDES FOR MODULATING TMEM106B EXPRESSION
    Publication number: 20240376474
    Abstract: The present disclosure relates to antisense oligonucleotides that are capable of modulating expression of TMEM106B in a target cell. The antisense oligonucleotides hybridize to TMEM106B mRNA. The present disclosure further relates to methods of using the antisense oligonucleotides described herein.
    Type: Application
    Filed: July 19, 2024
    Publication date: November 14, 2024
    Inventors: Amy EASTON, Helene GYLLING, Dennis HANSEN, Lukasz KIELPINSKI, Denia MELLAL, Helle NYMARK, Benny CHIH, Katarzyna CHYZYNSKA
  • THREOSE NUCLEIC ACID ANTISENSE OLIGONUCLEOTIDES AND METHODS THEREOF
    Publication number: 20240336920
    Abstract: Described are antisense oligonucleotides comprising one or more ?-L-threofuranosyl (TNA) nucleosides as well as methods to modulate the properties of antisense oligonucleotides by the introduction of TNA nucleosides. These are particularly applicable for antisense gapmer oligonucleotides.
    Type: Application
    Filed: June 20, 2024
    Publication date: October 10, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jessica Marine Aurore BASTIEN, Konrad BLEICHER, Helle CHRISTIANSEN, Erich KOLLER, Meiling LI, Helle NYMARK, Adrian SCHAEUBLIN, Steffen SCHMIDT
  • Oligonucleotides for Modulating Apolipoprotein E4 Expression
    Publication number: 20240294915
    Abstract: The present invention relates to antisense oligonucleotides that are capable of modulating expression of Apolipoprotein E4 (ApoE4) in a target cell. The oligonucleotides can hybridize to APOE ?4 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of, for example, Alzheimer's disease (AD), fronto-temporal dementia (FTD), Pick's disease (PiD), progressive supranuclear palsy (PSP), movement disorders such as Parkinson's disease (PD), dementia with Lewy Bodies, dementia in Down's Syndrome, and Niemann-Pick Type C1 Disease.
    Type: Application
    Filed: May 1, 2024
    Publication date: September 5, 2024
    Inventors: Helle NYMARK, Lykke PEDERSEN, Lynette FOO, Anja MOELHART HOEG, Lukasz KIELPINSKI