Patents by Inventor Helmut Buschmann

Helmut Buschmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7507816
    Abstract: Pharmaceutical compositions containing substituted aminoalcohols, the use of preparations containing substituted aminoalcohols for treatment of conditions such as pain, emesis, neurotropic conditions, cardiovascular diseases, urinary incontinence, diarrhea, pruritus, alcohol or drug dependency, inflammation, depression, decreased vigilance, or depressed libido, as well as 2-(aminomethyl)cycloalkane-1-ol compounds and a process for their preparation.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: March 24, 2009
    Assignee: Gruenenthal GmbH
    Inventors: Heinz Uragg, Corinna Maul, Helmut Buschmann, Bernd Sundermann, Hagen-Heinrich Hennies
  • Publication number: 20090043132
    Abstract: Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not a hydrogen atom and the diphosphine ligand is chiral.
    Type: Application
    Filed: May 1, 2008
    Publication date: February 12, 2009
    Applicant: Gruenenthal GmbH
    Inventors: Wolfgang Hell, Markus Kegel, Helmut Buschmann, Felix Spindler, Detlef Heller, Hans-Joachin Drexler
  • Patent number: 7417170
    Abstract: Methods for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl-amine compounds.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: August 26, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Wolfgang Hell, Markus Kegel, Bernhard Akteries, Helmut Buschmann, Jorg Holenz, Harmut Loebermann, Detlef Heller, Hans-Joachim Drexler, Stefan Gladow
  • Patent number: 7390812
    Abstract: N,N?-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N?-disubstituted piperazine compounds for the production of pharmaceutical preparations and in related methods of treatment.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: June 24, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Heinz Uragg, Corinne Maul, Helmut Buschmann, Bernd Sundermann, Hagen-Heinrich Hennies
  • Patent number: 7320980
    Abstract: The invention relates to substituted pyrido[1,2-a]pyrimidine compounds corresponding to formula (I) wherein: R1, R2 and R3 are as defined in the specification. Related pharmaceutical formulations and methods for inhibiting nitrogen oxide synthesis (NOS) and other treatments are also provided.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: January 22, 2008
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Hagen-Heinrich Hennies, Helmut Buschmann, Ullvi Bluhm, Bernd Clement, Dieter Heber, Ulrich Wolschendorf
  • Patent number: 7273952
    Abstract: Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceuticals.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: September 25, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Corinna Maul, Helmut Buschmann, Michael Finkam, Babette-Yvonne Koegel
  • Patent number: 7271192
    Abstract: Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I) wherein R1, R2, R3 and R4 have the meanings given in the description, and pharmaceutical compositions containing these compounds, as well as processes for the preparation of such compounds and intermediate products of this process, and related methods of treatment.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: September 18, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Corinna Sundermann, Bernd Sundermann, Helmut Buschmann, Hagen-Heinrich Hennies
  • Publication number: 20070213405
    Abstract: A novel crystalline form of a (?)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride compound, methods of producing the compound, and related methods of use including treatment methods and pharmaceutical compositions containing the compound.
    Type: Application
    Filed: December 28, 2006
    Publication date: September 13, 2007
    Applicant: Gruenenthal GmbH
    Inventors: Andreas Fischer, Helmut Buschmann, Michael Gruss, Dagmar Lischke
  • Publication number: 20070173533
    Abstract: Substituted 3-phenylpiperidine compounds corresponding to Formula I in which R1 and R2 have the meanings defined in the specification, methods for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting various conditions, especially pain.
    Type: Application
    Filed: January 26, 2007
    Publication date: July 26, 2007
    Applicant: Gruenenthal GmbH
    Inventors: Joerg Holenz, Helmut Buschmann, Michael Finkam
  • Patent number: 7235693
    Abstract: The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: June 26, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Wolfgang Hell, Markus Kegel
  • Publication number: 20070142681
    Abstract: The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary C1 group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.
    Type: Application
    Filed: February 9, 2007
    Publication date: June 21, 2007
    Applicant: GRUENENTHAL GmbH
    Inventors: Helmut Buschmann, Wolfgang Hell, Markus Kegel
  • Patent number: 7230018
    Abstract: Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrhea are provided.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: June 12, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Helmut Buschmann, Babette-Yvonne Koegel, Beatrix Merla, Nikolaus Risch
  • Patent number: 7217729
    Abstract: Substituted indoles of the formula I, a process for the production of such compounds, pharmaceutical preparations containing these compounds and the use of these compounds for alleviating pain.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: May 15, 2007
    Assignee: Grunenthal GmbH
    Inventors: Michael Sattlegger, Helmut Buschmann, Michael Przewosny, Werner Englberger, Babette-Yvonne Koegel, Hans Schick
  • Publication number: 20070088024
    Abstract: The present invention relates to an active substance combination comprising at least one substituted carbinol compound and at least one non-steroidal anti-inflammatory drug (NSAID), a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination for the manufacture of a medicament.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 19, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Helmut Buschmann, Bonifacio Gutierrez Silva, Jorg Holenz, Antonio Farre Gomis
  • Publication number: 20070082893
    Abstract: The present invention relates to an active substance combination comprising at least one substituted carbinol compound and at least one opioid, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 12, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A
    Inventors: Helmut Buschmann, Bonifacio Gutierrez Silva, Jorg Holenz, Antonio Farre Gomis
  • Publication number: 20070073056
    Abstract: The present invention relates to 4-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 29, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni TORRENS, Helmut BUSCHMANN, Jordi QUINTANA, Susana YENES, Josep MAS
  • Patent number: 7168937
    Abstract: The invention relates to a process for the enzymatic cleavage of racemates of aminomethyl-aryl-cyclohexanol derivatives.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: January 30, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Dagmar Kaulartz, Carsten Griebel, Hans-Joachim Gais
  • Publication number: 20070021398
    Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni TORRENS, Jordi QUINTANA, Helmut BUSCHMANN, Albert DORDAL, Josep MAS
  • Patent number: RE39530
    Abstract: 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: March 27, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Helmut Buschmann
  • Patent number: RE39593
    Abstract: 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: April 24, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs