Patents by Inventor Helmut Buschmann

Helmut Buschmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Active substance combination comprising a carbinol combined to at least an NSAID
    Publication number: 20070088024
    Abstract: The present invention relates to an active substance combination comprising at least one substituted carbinol compound and at least one non-steroidal anti-inflammatory drug (NSAID), a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination for the manufacture of a medicament.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 19, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Helmut Buschmann, Bonifacio Gutierrez Silva, Jorg Holenz, Antonio Farre Gomis
  • Active substance combination
    Publication number: 20070082893
    Abstract: The present invention relates to an active substance combination comprising at least one substituted carbinol compound and at least one opioid, a medicament comprising said active substance combination, a pharmaceutical formulation comprising said active substance combination and the use of said active substance combination for the manufacture of a medicament.
    Type: Application
    Filed: October 5, 2006
    Publication date: April 12, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A
    Inventors: Helmut Buschmann, Bonifacio Gutierrez Silva, Jorg Holenz, Antonio Farre Gomis
  • 4-Substituted Pyrazoline Compounds, their Preparation and Use as Medicaments
    Publication number: 20070073056
    Abstract: The present invention relates to 4-substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 29, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni TORRENS, Helmut BUSCHMANN, Jordi QUINTANA, Susana YENES, Josep MAS
  • Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives
    Patent number: 7168937
    Abstract: The invention relates to a process for the enzymatic cleavage of racemates of aminomethyl-aryl-cyclohexanol derivatives.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: January 30, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Dagmar Kaulartz, Carsten Griebel, Hans-Joachim Gais
  • Substituted Pyrazoline Compounds, their Preparation and Use as Medicaments
    Publication number: 20070021398
    Abstract: The present invention relates to substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni TORRENS, Jordi QUINTANA, Helmut BUSCHMANN, Albert DORDAL, Josep MAS
  • 2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants
    Patent number: 7105538
    Abstract: Substituted 2-pyrrolidin-2-yl compounds corresponding to formula I a method for their production, pharmaceutical compositions containing them, and methods of using them, especially for treating pain and/or depression.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: September 12, 2006
    Assignee: Gruenenthal GmbH
    Inventors: Hagen-Heinrich Hennies, Corinna Sundermann, Helmut Buschmann, Bernd Sundermann
  • Process for the preparation of substitued 3-aryl-butylamine compounds
    Publication number: 20060194988
    Abstract: Methods for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl-amine compounds.
    Type: Application
    Filed: December 6, 2005
    Publication date: August 31, 2006
    Inventors: Wolfgang Hell, Markus Kegel, Berhard Akteries, Helmut Buschmann, Joerg Holenz, Harmut Loebermann, Detlef Heller, Hans-Joachim Drexler, Stefan Gladow
  • 5-HT7 receptor antagonists
    Publication number: 20060142321
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Application
    Filed: February 2, 2005
    Publication date: June 29, 2006
    Inventors: Antoni Jover, Susana Yenes Minguez, Jose Mas Prio, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Buschmann
  • Process for obtaining enantiomers of Cizolirtine
    Publication number: 20060142589
    Abstract: A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric reduction of a prochiral ketone in the presence of a chiral ruthenium (II) catalyst system including at least a bidentate phosphorous-containing ligand and a diamine ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield corresponding pharmaceutically active ethanamines.
    Type: Application
    Filed: January 24, 2005
    Publication date: June 29, 2006
    Inventors: Antoni Torrens Jover, Helmut Buschmann, Detleff Heller, Hans Drexler
  • 5-HT7 receptor antagonists
    Publication number: 20060142332
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Application
    Filed: February 2, 2005
    Publication date: June 29, 2006
    Inventors: Antoni Torrens Jover, Susana Yenes Minguez, Jose Prio, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Buschmann
  • PROCESS FOR OBTAINING ENANTIOMERS OF THIENYLAZOLYLALCOXYETHANAMINES
    Publication number: 20060135787
    Abstract: A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine and in general for thienylazolylalcoxyethanamines and their enantiomers. The process involves asymmetric addition of a metalated thienyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield the corresponding pharmaceutically active thienylazolylalcoxyethanamines.
    Type: Application
    Filed: January 24, 2005
    Publication date: June 22, 2006
    Inventors: Antoni Jover, Helmut Buschmann, Stefan Dahmen, Matthias Lormann
  • PROCESS FOR OBTAINING CIZOLIRTINE AND ITS ENANTIOMERS
    Publication number: 20060135788
    Abstract: A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric addition of a metalated phenyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield Cizolirtine or its enantiomers.
    Type: Application
    Filed: January 24, 2005
    Publication date: June 22, 2006
    Inventors: Antoni Jover, Helmut Buschmann, Stefan Dahmen, Matthias Lormann
  • Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds
    Patent number: 7064236
    Abstract: The invention relates to substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds, to a method for the production thereof, to medicaments containing said compounds and to their use in the production of medicaments.
    Type: Grant
    Filed: January 5, 2004
    Date of Patent: June 20, 2006
    Assignee: Grunenthal GmbH
    Inventors: Bernd Sundermann, Corinna Sundermann, Helmut Buschmann, Babette-Yvonne Koegel
  • Substituted benzo [b] azepin-2-one compounds
    Patent number: 7041662
    Abstract: The invention relates to substituted benzo[b]azepin-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: May 9, 2006
    Assignee: Grunenthal GmbH
    Inventors: Michael Sattlegger, Helmut Buschmann, Michael Przewosny, Werner Englberger, Babette-Yvonne Koegel, Hans Schick
  • Substituted pyrido(1,2-A) pyrimidines and their use as NOS inhibitors
    Publication number: 20060084664
    Abstract: The invention relates to substituted pyrido[1,2-a]pyrimidine compounds corresponding to formula (I) wherein: R1, R2 and R3 are as defined in the specification. Related pharmaceutical formulations and methods for inhibiting nitrogen oxide synthesis (NOS) and other treatments are also provided.
    Type: Application
    Filed: September 6, 2005
    Publication date: April 20, 2006
    Applicant: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Hagen-Heinrich Hennies, Helmut Buschmann, Ullvi Bluhm, Bernd Clement, Dieter Heber, Ulrich Wolschendorf
  • Substituted 1-aminobutan-3-ol compounds
    Patent number: 7022739
    Abstract: Substituted 1-aminobutane-3-ol compounds, methods for producing them, pharmaceutical compounds containing them, and the use of substituted 1-aminobutane-3-ol compounds for producing pharmaceutical compounds.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: April 4, 2006
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Corinna Maul, Bernd Sundermann, Utz-Peter Jagusch, Michael Haurand, Boris Chizh
  • 5-HT7 receptor antagonists
    Publication number: 20060040978
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 23, 2006
    Inventors: Antoni Torrens Jover, Josep Mas Prio, Susana Yenes Minguez, Monica Garcia Lopez, Alberto Dordal Zueras, Luz Romero Alonso, Helmut Buschmann
  • 5-HT7 receptor ligands
    Publication number: 20060040977
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Application
    Filed: August 18, 2004
    Publication date: February 23, 2006
    Inventors: Antoni Torrens Jover, Josep Mas Prio, Susana Yenes Minguez, Monica Garcia Lopez, Alberto Dordal Zueras, Luz Romero Alonso, Helmut Buschmann
  • 3-amino-3-arylpropan-1-ol-compounds, their preparation and use
    Patent number: RE39530
    Abstract: 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: March 27, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Bernd Sundermann, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Helmut Buschmann
  • 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects
    Patent number: RE39593
    Abstract: 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: April 24, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs