Patents by Inventor Henri Cousse

Henri Cousse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4456614
    Abstract: The present invention concerns chemical compounds of the general formula: ##STR1## in which: R.sub.1 and R.sub.2 may be identical or different and represent a hydrogen or halogen atom or else a lower alkyl, lower alkoxy, nitro or acetyl group andR represents a lower alkyl or lower aralkyl group, such as benzyl.These compounds are useful in therapy for the treatment of hypertension and cardiac arrhythmia.
    Type: Grant
    Filed: April 2, 1981
    Date of Patent: June 26, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Pol Vilain
  • Patent number: 4409241
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: October 11, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4382930
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: May 10, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4380667
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: April 19, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4372975
    Abstract: The invention relates to new substituted 2-benzoyl-4-chloroglycinanilide derivatives, to a process for their production and to their use as medicaments.The new derivatives according to the invention correspond to the general formula ##STR1## in which: R may be a linear or branched alkyl group, preferably a lower alkyl group;R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, alkyl, alkenyl, alkynyl, hydroxy alkyl, alkoxy alkyl and aralkyl groups, these various groups optionally being linear or branched, and from 3- to 6-membered cycloalkyl groups optionally substituted on the .alpha.-carbon atom by an alkynyl radical;in addition, the groups R.sub.1 and R.sub.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: February 8, 1983
    Assignee: Pierre Fabre SA
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger, Sylvano Casadio
  • Patent number: 4370347
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: January 25, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4289770
    Abstract: New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.
    Type: Grant
    Filed: June 13, 1980
    Date of Patent: September 15, 1981
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin
  • Patent number: 4246271
    Abstract: The present invention relates to new derivatives of 4-phenyl-2-thiazolyl oxamates having the formula: ##STR1## in which: X represents hydrogen, halogen, lower-alkyl, or lower-alkoxy.R is lower-alkyl or phenyllower-alkyl, e.g., benzyl.These compounds, which have inhibiting properties on the passive cutaneous anaphylactic reaction, are useful in the treatment of asthma. Pharmaceutical compositions thereof and method of treating therewith.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: January 20, 1981
    Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Tarayre, Silvano Casadio
  • Patent number: 4225610
    Abstract: The present invention concerns new derivatives of 4-phenyl 2-amino thiazole of the formula ##STR1## in which X represents a hydrogen atom, a halogen, a lower alkyl or an alkoxy,R is a hydrogen, a haloalkoxy, a substituted or unsubstituted aryl, a pyridyl, an aryloxy or a carboxy alkyl, having immunomodulating properties, useful in the treatment of rheumatoid arthritis and other ailments requiring immunotherapy.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: September 30, 1980
    Assignee: Pierre Fabre, S.A.
    Inventors: Jean-Pierre Tarayre, Henri Cousse, Gilbert Mouzin, Henri Lauressergues, Silvano Casadio
  • Patent number: 4192883
    Abstract: New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic,.alpha.-phenyl-.alpha.-ethylacetic, diphenylacetic, benzilic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 10-phenothiazinecarboxylic, benzoic, halobenzoic, 3-coumarincarboxylic, 9-xanthenecarboxylic, salicylic, cresotic, halocresotic, lower-alkoxybenzoic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, cinnamic, or 9-fluorene carboxylic acid, and wherein R'H represents an inorganic or organic acid, and wherein R may be, for example, a substituted aromatic ring of the formula: ##STR3## wherein R.sub.1 and R.sub.2 may independently be lower-alkyl, lower-alkoxy, hydrogen, lower-alkenyloxy, or lower-alkynyloxy, and X may be hydrogen or halogen.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: March 11, 1980
    Assignee: Pierre Fabre, S.A.
    Inventors: Henri Cousse, Bernard Bonnaud, Jean-Pierre Tarayre, Silvano Casadio
  • Patent number: 4188387
    Abstract: The invention relates to new chemical compounds which can be used as analgesic drugs and their preparation.The new chemical compounds have the general formula: ##STR1## in which: R is a lower alkylR.sub.1, which is always other than H, is a linear or branched lower alkyl, an allyl, amino alkyl of type ##STR2## in which n=2 to 4, R.sub.2 R.sub.3 represent a lower alkyl; they may also form a heterocycle with the nitrogen atom.Y is a hydrogen, halogen, lower alkyl, alkoxy, ##STR3## R being a lower alkyl. The position of Y is variable on the ring.X=oxygen or sulfur atom.The drugs containing these active principles may be used in the treatment of rheumatismal disturbances and various pains.
    Type: Grant
    Filed: March 9, 1978
    Date of Patent: February 12, 1980
    Assignee: Pierre Fabre S.A.
    Inventors: Guy Pitet, Henri Cousse, Gilbert Mouzin, Antoine Stenger
  • Patent number: 4167566
    Abstract: The invention relates to compounds of the formula ##STR1## in which R and R' are identical or different and may be a hydrogen, an alkyl, a dialkylamino, an alkoxy, a halogen, or a hydroxy. These compounds are useful as drugs in the control of thromboses.
    Type: Grant
    Filed: March 9, 1978
    Date of Patent: September 11, 1979
    Assignee: Pierre Fabre, S.A.
    Inventors: Guy Pitet, Henri Cousse, Gilbert Mouzin, Andre Delhon
  • Patent number: 4152521
    Abstract: The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.
    Type: Grant
    Filed: August 7, 1978
    Date of Patent: May 1, 1979
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin
  • Patent number: 4122199
    Abstract: New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic, 60 -phenyl-.alpha.-(1 to 5 C atoms) acetic, (1 to 5 C atoms) diphenylacetic, benzilic, diphenyl-.alpha.-chloroacetic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 3-coumarincarboxylic, 9-xanthenecarboxylic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, or 9-flourene carboxylic acid, and wherein R'H represents an inorganic or organic acid.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
    Type: Grant
    Filed: August 16, 1976
    Date of Patent: October 24, 1978
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Bernard Bonnaud, Jean-Pierre Tarayre, Silvano Casadio
  • Patent number: 4122181
    Abstract: The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: October 24, 1978
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin
  • Patent number: 4098879
    Abstract: The present invention relates to new chemical compounds which can be used as inhibitors of dental plaque, and orally-acceptable compositions thereof, combinations thereof with known compounds having an inhibitory action on the formation of dental plaque, such as biguanidines, and method of treating therewith for the prevention of dental plaque or tartar and dental caries.The new compounds have the general formula ##STR1## in which R.sub.1 = H or alkylR.sub.2 = ch.sub.2 oh, alkyl carboxylate, ##STR2## and R.sub.2 is in 2 or 3 position.Compositions containing these active principles are useful in particular in the preventive treatment of periodontopathies and odontopathies and in the field of oral-dental hygiene.
    Type: Grant
    Filed: January 3, 1977
    Date of Patent: July 4, 1978
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Jean-Claude Vezin, Lucien Dussourd d'Hinterland, Jacques Dubois
  • Patent number: 4060637
    Abstract: The invention relates to new chemical compounds which can be used as drugs, as well as pharmaceutical compositions.The new products have the general formula: ##STR1## Drugs containing these active principles can be administered orally, rectally, parenterally or locally and are intended in particular for use as psychotropics, either alone or associated with other active principles. 5-Bromo-ortho-cresotamide may also be named 5-Bromo-2-hydroxy-3-methyl-benzamide.
    Type: Grant
    Filed: November 21, 1974
    Date of Patent: November 29, 1977
    Assignee: Pierre Fabre SA
    Inventors: M. Antoine Stenger, Henri Cousse, M. Gilbert Mouzin
  • Patent number: 4058558
    Abstract: This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same.The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R.sub.1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy.R.sub.2 is hydrogen or alkoxy.R.sub.1 and R.sub.2 may form a ring, for instance: phenyl or cyclohexyl.R.sub.3 is always other than hydrogen, being either methyl (CH.sub.3) or methylene. When R.sub.3 is CH.sub.3, a double bond is present between the A and B carbons. When R.sub.3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms.R.sub.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: November 15, 1977
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Jean-Pierre Rieu
  • Patent number: RE30309
    Abstract: The present invention relates to new chemical compounds which can be used as inhibitors of dental plaque, and orally-acceptable compositions thereof, combinations thereof with known compounds having an inhibitory action on the formation of dental plaque, such as biguanidines, and method of treating therewith for the prevention of dental plaque or tartar and dental caries.The new compounds have the general formula ##STR1## in which R.sub.1 =H or alkylR.sub.2 =CH.sub.2 OH, alkyl carboxylate, ##STR2## and R.sub.2 is in 2 or 3 position.Compositions containing these active principles are useful in particular in the preventive treatment of periodontopathies and odontopathies and in the field of oral-dental hydgiene.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: June 17, 1980
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Jean-Claude Vezin, Lucien D. d'Hinterland, Jacques Dubois
  • Patent number: RE31237
    Abstract: New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.
    Type: Grant
    Filed: February 19, 1982
    Date of Patent: May 10, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin