Patents by Inventor Henri Inion
Henri Inion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5567827Abstract: The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom,R represents a (C.sub.1 -C.sub.6) alkyl, (C.sub.3 -C.sub.6) cycloalkyl or phenyl radical,R.sub.3 represents hydrogen or a halogen atom,X represents --O--, --S-- or --NR.sub.4 -- in which R.sub.4 represents hydrogen or a (C.sub.1 -C.sub.4) alkyl group,useful as synthetic intermediates, especially for the preparation of aminoalkoxyphenylsulphonyl derivatives which are pharmaceutically active compounds.Type: GrantFiled: June 7, 1995Date of Patent: October 22, 1996Assignee: Elf SanofiInventors: Jean Gubin, Henri Inion
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Patent number: 5508431Abstract: The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom,R represents a (C.sub.1 -C.sub.6) alkyl, (C.sub.3 -C.sub.6) cycloalkyl or phenyl radical,R.sub.3 represents hydrogen or a halogen atom,X represents --O--, --S-- or --NR.sub.4 -- in which R.sub.4 represents hydrogen or a (C.sub.1 -C.sub.4) alkyl group, useful as synthetic intermediates, especially for the preparation of aminoalkoxyphenylsulphonyl derivatives which are pharmaceutically active compounds.Type: GrantFiled: September 8, 1994Date of Patent: April 16, 1996Assignee: Elf SanofiInventors: Jean Gubin, Henri Inion
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Patent number: 5444056Abstract: An aminoalkoxyphenyl derivative of general formula:Cy--B--Ph--O--A--Am (1)as well as a pharmaceutically acceptable salt thereof in whichB represents a --S--, --SO-- or --SO.sub.2 -- group,Ph represents an optionally substituted phenyl radical,A denotes a straight or branched alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxy propylene radical in which the hydroxy is optionally substituted by a C.sub.1 -C.sub.4 alkyl radical.Am represents a group: ##STR1## and Cy is a cyclic group, provided that when Cy represents either a benzo[b]furyl group substituted at position 4 by a halogen atom or a C.sub.1 -C.sub.4 alkyl group, or a benzo[b]thienyl group substituted at position 4 by a halogen atom or by a C.sub.1 -C.sub.4 alkyl group and when B represents a --SO.sub.2 -- group, R.sub.3 represents a --Alk--Ar radical.Type: GrantFiled: February 7, 1990Date of Patent: August 22, 1995Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Henri Inion, Gilbert Rosseels
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Patent number: 5401855Abstract: The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom,R represents a (C.sub.1 -C.sub.6) alkyl, (C.sub.3 -C.sub.6) cycloalkyl or phenyl radical,R.sub.3 represents hydrogen or a halogen atom, X represents --O--, --S-- or --NR.sub.4 -- in which R.sub.4 represents hydrogen or a (C.sub.1 -C.sub.4) alkyl group, useful as synthetic intermediates, especially for the preparation of aminoalkoxyphenylsulphonyl derivatives which are pharmaceutically active compounds.Type: GrantFiled: June 23, 1993Date of Patent: March 28, 1995Assignee: Elf SanofiInventors: Jean Gubin, Henri Inion
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Patent number: 5223510Abstract: The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T' and T"represent particularly a group: ##STR3## R and R.sub.a, identical or different, represent X represent --O-- or --S--Y represents a radical ##STR4## These compounds are useful as medecines particularly for the treatment of pathological syndroms of the cardio-vascular system.Type: GrantFiled: July 26, 1991Date of Patent: June 29, 1993Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Jean Lucchetti, Gilbert Rosseels, Henri Inion
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Patent number: 5215988Abstract: The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --,R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen,A is selected from a straight- or branched-alkylene radical having from 2 to 5 carbon atoms, a 2-hydroxypropylene radical, and a 2-(lower alkoxy) propylene radical,R.sub.3 is selected from C.sub.1 -C.sub.8 alkyl and a radical of formula:--Alk--Arin which Alk is selected from a single bond and a linear- or branched-alkylene radical having from 1 to 5 carbon atoms; and Ar is selected from pyridyl, phenyl, 2-3-methyleneoxyphenyl, 3,4-methylenedioxyphenyl and phenyl substituted with one or more substituents, which may be identical or different, selected from halogen atoms, C.sub.1 -C.sub.8 alkyl groups and C.sub.1 -C.sub.8 alkoxy groups,R.sub.4 is selected from hydrogen and C.sub.1 -C.sub.8 alkyl, orR.sub.3 and R.sub.Type: GrantFiled: August 14, 1991Date of Patent: June 1, 1993Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5182291Abstract: Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen,A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical,R.sub.3 denotes an alkyl radical or a radical of formula:--Alk--R.sub.5in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups,R.sub.4 denotes hydrogen or an alkyl radical orR.sub.3 and R.sub.Type: GrantFiled: June 17, 1991Date of Patent: January 26, 1993Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5039700Abstract: Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen,A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical,R.sub.3 denotes an alkyl radical or a radical of formula:--Alk--R.sub.5in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups,R.sub.Type: GrantFiled: March 19, 1990Date of Patent: August 13, 1991Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 5017579Abstract: The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.Type: GrantFiled: February 6, 1989Date of Patent: May 21, 1991Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat, Gerard Le Fur
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Patent number: 4994474Abstract: The present invention relates to aminoalkoxyphenyl derivatives of formula: ##STR1## and its N-oxide and pharmaceutically acceptable salts, in which: B represents a--S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radial or a halogen atom,A denotes a straight-or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radial in which the hydroxy is optionally substituted by a lower alkyl radical,R.sub.3 denotes an alkkyl radical or a radical of formula:--Alk--Arin which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and Ar denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl group or lower alkoxy groups,R.sub.Type: GrantFiled: February 6, 1989Date of Patent: February 19, 1991Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Henri Inion
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Patent number: 4957925Abstract: An aminoalkoxyphenyl compound of formula ##STR1## as well as a pharmaceutically acceptable salt of this compound.Type: GrantFiled: August 7, 1987Date of Patent: September 18, 1990Assignee: SanofiInventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat
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Patent number: 4520026Abstract: Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,X.sub.1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy,A represents a group selected from: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X.sub.3 represents hydrogen, chlorine, bromine, iodine or methyl,R.sub.1 represents a methyl, ethyl, n-propyl or n-butyl radical,n represents an integer in the range of 2 to 6 inclusive,with the proviso that when both X.sub.2 and X.sub.3 represent hydrogen or methyl, X.sub.1 is other than hydrogen.They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.Type: GrantFiled: June 29, 1982Date of Patent: May 28, 1985Assignee: S. A. Labaz N.V.Inventors: Gilbert Rosseels, Henri Inion
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Patent number: 4378362Abstract: Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,X.sub.1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy,A represents a group selected from: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X.sub.3 represents hydrogen, chlorine, bromine, iodine or methyl,R.sub.1 represents a methyl, ethyl, n-propyl or n-butyl radical,n represents an integer in the range of 2 to 6 inclusive,with the proviso that when both X.sub.2 and X.sub.3 represent hydrogen or methyl, X.sub.1 is other than hydrogen.They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.Type: GrantFiled: February 6, 1981Date of Patent: March 29, 1983Assignee: S.A. Labaz N.V.Inventors: Gilbert Rosseels, Henri Inion
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Patent number: 4012394Abstract: 3-Indolyl pyridyl ketones of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 representsA straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion by a chlorine atom or a methoxy groupOr ##STR2## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R.sub.4 and R.sub.5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R.sub.4 and R.sub.5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group,R.sub.2 representsA branched-or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; andR.sub.3 representsA 2-pyridyl, 3-pyridyl or 4-pyridyl group.They are effective as fibrinolytic and anti-inflammatory agents.Type: GrantFiled: August 4, 1975Date of Patent: March 15, 1977Assignee: LabazInventors: Marcel Descamps, Henri Inion
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Patent number: 3946029Abstract: 3-Indolyl pyridyl ketones of the general formula: ##SPC1##And pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 representsA straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion of a chlorine atom or a methoxy groupOr ##EQU1## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R.sub.4 and R.sub.5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R.sub.4 and R.sub.5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group,R.sub.2 representsA branched- or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; andR.sub.3 representsA 2-pyridyl, 3-pyridyl or 4-pyridyl group.They are effective as fibrinolytic and anti-inflammatory agents.Type: GrantFiled: January 31, 1974Date of Patent: March 23, 1976Assignee: LabazInventors: Margel Descamps, Henri Inion