Patents by Inventor Henry J. Lee

Henry J. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10633381
    Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: April 28, 2020
    Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.
    Inventors: James F. Blake, Laurence E. Burgess, Mark Joseph Chicarelli, James Gail Christensen, Jay Bradford Fell, John P. Fischer, John J. Gaudino, Erik James Hicken, Ronald Jay Hinklin, Matthew Randolf Lee, Matthew Arnold Marx, Macedonio J. Mejia, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P. A. Vigers, Henry J. Zecca
  • Patent number: 6207598
    Abstract: A multilayer papermaking fabric having interwoven machine direction (MD) and cross-machine direction (CMD) yarns, the CMD yarns defining at least upper and lower CMD yarn subsets which are interwoven with the MD yarns in a repeat pattern such that the MD yarns have substantially more interweavings with the upper CMD yarn subset than with the lower CMD yarn subset. The upper subset CMD yarns define sheetside floats over at least seven MD yarns and each MD yarn interweaves with only two upper subset CMD yarns in a given repeat.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: March 27, 2001
    Assignee: AstenJohnson, Inc.
    Inventors: Henry J. Lee, Rex A. Treece, Rachel H. Kramer
  • Patent number: 6189577
    Abstract: A method for weaving a papermakers fabric having a system of flat monofilament machine direction yarns (hereinafter MD yarns) which are stacked to control the permeability of the fabric. The system of MD yarns comprises at least upper and lower layers of yarns. Preferably, each upper MD yarn is paired in a vertically stacked orientation with a lower MD yarn. In a low permeability embodiment, at least the upper MD yarns are flat monofilament yarns woven contiguous with each other.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: February 20, 2001
    Assignee: AstenJohnson, Inc.
    Inventor: Henry J. Lee
  • Patent number: 6158478
    Abstract: A multilayer papermaking fabric having interwoven machine direction (MD) and cross-machine direction (CMD) yarns, the CMD yarns defining at least upper and lower CMD yarn subsets which are interwoven with the MD yarns in a repeat pattern such that the MD yarns have substantially more interweavings with the upper CMD yarn subset than with the lower CMD yarn subset. The lower subset CMD yarns define machine side floats under at least seven MD yarns and each MD yarn interweaves with only two lower subset CMD yarns in a given repeat.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: December 12, 2000
    Assignee: AstenJohnson, Inc.
    Inventors: Henry J. Lee, T. Payton Crosby, Jeff Clegg, Rachel Kramer
  • Patent number: 6079454
    Abstract: An opened ended, endless woven papermaker's fabric having a plurality of longitudinal yarns and a plurality of transverse yarns woven in a selected weave pattern to form a fabric body and seaming loops, the fabric characterized by a longitudinal yarn weave repeat having selected yarns woven as the seaming loops and selected yarns woven in the fabric body and defining a fabric edge.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: June 27, 2000
    Assignee: AstenJohnson, Inc.
    Inventors: Henry J. Lee, Billy Summer
  • Patent number: 6000441
    Abstract: An endless woven papermaker's fabric of having warp yarns in at least two layers and continuous weft yarns in at least two layers. The warp and weft yarns are interwoven to form a fabric where the first warp yarn layer is adjacent to the second warp layer and the weft yarns define seam loops at two ends of the fabric. Each end of the fabric has at least one warp yarn which is free of interweaving with the weft yarns and is removed to form the seam loops.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: December 14, 1999
    Assignee: Asten, Inc.
    Inventors: Henry J. Lee, Billy Summer
  • Patent number: 5975149
    Abstract: A papermaker's fabric of a type for use in high temperature operations and including interwoven machine direction (MD) and cross-machine direction (CMD) yarns that define a base fabric and a paper support layer. The fabric is characterized by the paper support layer including high temperature MD yarns woven in a repeat pattern that includes a float over at least seven CMD yarns.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: November 2, 1999
    Assignee: Asten, Inc.
    Inventors: Henry J. Lee, Paul H. Sutherland
  • Patent number: 5975148
    Abstract: A papermakers fabric, having top and bottom surfaces, woven from machine direction yarns and one layer of cross machine direction yarns. The cross machine direction yarns comprise relatively large and small yarns and the machine and cross machine direction yarns are arranged such that the machine direction yarns define floats on one of the surfaces of the fabric and knuckles below the one surface around small cross machine direction yarns. The parts of the machine direction yarns defining the knuckles below the one surface do not extend to the plane of the other surface of the fabric.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: November 2, 1999
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5913339
    Abstract: An open ended papermaker's fabric having first and second layers of machine direction (MD) yarns interwoven with a plurality of cross machine direction (CMD) yarns. Additional CMD yarns are interwoven with both MD layers at each end of the fabric between the last CMD yarn and the seam loops in a balancing weave that establishes vertical and horizontal alignment for the seam loops.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 22, 1999
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5865219
    Abstract: A double layer papermaking fabric having first and second layers of cross machine direction (CMD) yarns interwoven with a system of machine direction (MD) yarns. The MD repeat pattern is characterized by a portion that weaves exclusively with the first CMD layer, a portion that transitions between the layers, a portion that weaves exclusively with the second CMD layer and a portion that transitions between the layers.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: February 2, 1999
    Assignee: Asten, Inc.
    Inventors: Henry J. Lee, T. Payton Crosby
  • Patent number: 5738151
    Abstract: A shed formation device with a frame assembly having at least two harnesses mounted for movement in the frame. Each harness includes a plurality of heddles through which CMD yarns are passed. The existing cross machine direction (CMD) yarns of the fabric pass over an out-feed bar mounted to the frame assembly as they exit the heddles. A replacement CMD yarn supply provides replacement CMD yarns to the heddles for reweaving with the machine direction (MD) yarns to form seam loops and finished fabric ends. The replacement CMD yarns pass over an in-feed bar, mounted to the frame assembly, prior to passing through the heddles. The harnesses are manipulated to form an unweaving shed in the existing CMD yarns and re-weaving shed in the replacement CMD yarns. Retractable expansion forks assist the unweaving and reweaving of the MD yarns. A leasing device captures MD yarns from the unweaving shed and releases them into the reweaving shed to form seam loops and finished ends.
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: April 14, 1998
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5713396
    Abstract: A papermakers fabric having a system of flat monofilament machine direction yarns (hereinafter MD yarns) which are stacked to control the permeability of the fabric. The system of MD yarns comprises at least upper and lower layers of yarns. Preferably, each upper MD yarn is paired in a vertically stacked orientation with a lower MD yarn. Preferably, multiple layers of stacked CMD yarns are provided which are maintained in the stacked relationship by the flat stacked MD yarns to provide suitable void volume within the fabric. In a low permeability embodiment, at least the upper MD yarns are flat monofilament yarns woven contiguous with each other.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: February 3, 1998
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5690149
    Abstract: A papermakers fabric having a system of cross machine direction yarns interwoven with flat monofilament machine direction yarns. The flat machine direction yarns are arranged in stacked pairs. At least the upper machine direction yarns have an aspect ratio greater than 3:1 and weave in a float pattern over multiple cross machine direction yarns.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: November 25, 1997
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5645112
    Abstract: A papermakers fabric having a system of flat monofilament yarns interwoven in a balanced weave pattern with preferably the flat yarns being machine direction yarns woven in stacked pairs with a single layer of cross machine direction yarns. The preferred weave pattern is selected such that the machine direction yarns impart crimp to alternate cross machine direction yarns by selectively weaving floats over multiple adjacent CMD yarns and knuckles under single CMD yarns. The invention provides for the use of flat yarns having an aspect ratio greater than 3:1.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5449026
    Abstract: A papermakers fabric having a system of flat monofilament yarns which are woven with relatively long floats on at least one side of the fabric. In the preferred embodiment, the flat yarns are oriented in the machine direction of the papermakers fabric and are interwoven with at least a top layer of round cross machine direction yarns such that in each repeat, the flat yarns float over more top layer cross machine direction yarns than the number of top layer yarns which the flat yarns weave under. In the preferred embodiment, pairs of vertically stacked flat monofilament yarns are woven in the machine direction such that the upper flat yarns define relatively long floats on the top surface of the fabric and the lower flat yarns define floats on the bottom surface of the fabric.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: September 12, 1995
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5411062
    Abstract: A flat woven pin-seamed papermakers fabric wherein machine direction yarns define a series of seaming loops on the opposing fabric ends. The fabric comprises a system of flat monofilament machine direction warp yarns (hereinafter MD yarns) which are woven in a selected weave construction. In a preferred embodiment, the system of MD yarns comprises upper and lower yarns which are vertically stacked. Selected end segments of the upper and lower MD yarns are removed and yarn segments made of a more durable material are rewoven into the fabric end in the space vacated by the trimmed upper and lower MD yarn end segments. Non-loop forming upper MD yarns are preferably backwoven into the space vacated by trimming respective lower MD yarns. Preferably, at least the upper MD yarns are woven contiguous with each other to lock in the machine direction alignment of the stacking pairs of MD yarns and the orthogonal orientation of the end loops.
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: May 2, 1995
    Assignee: Asten Group, Inc.
    Inventor: Henry J. Lee
  • Patent number: 5343896
    Abstract: A papermakers fabric having a system of monofilament machine direction yarns (hereinafter MD yarns) which control the permeability of the fabric. The present weave provides for usage of high aspect ratio yarns as structural weave components. The system of MD yarns comprises multiple layers of yarns which are vertically stacked. Preferably, upper MD yarns define floats on the upper surface of the fabric and each upper MD yarn is grouped in a vertically stacked orientation with an intermediate and a lower MD yarn.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: September 6, 1994
    Assignee: Asten Group, Inc.
    Inventors: Ernst Schroder, Henry J. Lee
  • Patent number: H1974
    Abstract: A papermaker's fabric having a system of primary machine direction yarns which form seaming loops at each end of the fabric and a system of secondary machine direction yarns. A system of cross-machine direction yarns are interwoven with the primary and secondary systems of machine direction yarns in a weave pattern that provides adjacent balancing yarns that maintain the seam loops in substantially vertical alignment.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: July 3, 2001
    Assignee: AstenJohnson, Inc.
    Inventors: Henry J. Lee, Billy Summer
  • Patent number: RE35966
    Abstract: A flat woven pin-seamed papermakers fabric wherein machine direction yarns define a series of seaming loops on the opposing fabric ends. The fabric comprises a system of flat monofilament machine direction warp yarns (hereinafter MD yarns) which are woven in a selected weave construction. In a preferred embodiment, the system of MD yarns comprises upper and lower yarns which are vertically stacked. Selected end segments of the upper and lower MD yarns are removed and yarn segments made of a more durable material are rewoven into the fabric end in the space vacated by the trimmed upper and lower MD yarn end segments. Non-loop forming upper MD yarns are preferably backwoven into the space vacated by trimming respective lower MD yarns. Preferably, at least the upper MD yarns are woven contiguous with each other to lock in the machine direction alignment of the stacking pairs of MD yarns and the orthogonal orientation of the end loops.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: November 24, 1998
    Assignee: Asten, Inc.
    Inventor: Henry J. Lee
  • Patent number: D430113
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: August 29, 2000
    Assignee: Alstom UK Limited
    Inventor: Henry J. Lee