Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

Abstract: Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

Abstract: Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.

Abstract: The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

Abstract: A lamp includes a dichroic filter, a light emitting diode, and a lampshade. The light emitting diode emits light towards the dichroic filter. One portion of the light within a predetermined frequency range passes through the dichroic filter. The other portion of the light is refracted by the dichroic filter. The lampshade is used for shading the light. Therefore, the lampshade shows two colors of light.

Abstract: Disclosed herein are representative embodiments of methods and apparatus for managing and allocating hardware resources during RTL synthesis. For example, in one exemplary method disclosed herein, an RTL description of a circuit to be implemented in a target architecture is received. The target architecture of this embodiment comprises a fixed number of hardware resources in a class of hardware resources. One or more operator instances are determined from the RTL description received, where at least some of the operator instances are implementable by the hardware resources in the class of hardware resources. In this embodiment, and prior to initially synthesizing the RTL description into a gate-level netlist, assignment information indicative of how the operator instances are to be implemented using the hardware resources in the class of hardware resources is automatically determined. A graphical user interface is also provided that allows a user to view and modify the assignment information.

Abstract: Disclosed are methods and systems for implementing constraint and connectivity aware physical designs. The method or system provides a connectivity-aware environment to implement electronic designs. For example, the method interactively determines whether an electronic design complies with various constraints by using connectivity information in a nearly real-time manner while the electronic design is being created in some embodiments. The method or system uses the connectivity information provided by a connectivity engine or specified by designers to present feedback to a user as to whether a newly created object or a newly modified object complies or violates certain relevant constraints in an interactive manner or in nearly real-time without having to perform such constraints checking in batch mode. The method further enables one to implement electronic designs by using connectivity information without performing extraction on layouts or rebuilding nets.

Abstract: A hair styling and drying apparatus has a pair of pivotally connected arms, styling surfaces on the arms, air suction and discharge orifices in the styling surfaces, and a blower for blowing air through the air orifices and recycling air between the arms. At least some suction orifices of one styling surface can align with at least some discharge orifices of the other styling surface. The blowers blow air out the discharge orifices and suck air into the suction orifices, thereby recycling much of the blown air. The apparatus can include heaters for heating the blown air and for heating the styling surfaces.

Abstract: Various embodiments provide a constraint-driven environment to interactively determine coloring of layout components when the layout components are being modified or created and to provide feedback with visual aids to users in nearly real-time. Layout components are thus appropriately assigned to respective mask designs upon their creation. Various embodiments check or verify various constraints during creation or modification of layout components, and the layout thus remains design rule clean as constructed. Some embodiments use data structure(s) including information associated with mask identifications of objects of a cluster to change some mask identifications without considering any of the constraints governing these mask identifications. Some embodiments further determine the mask identification for an object based at least in part on whether object splitting and stitching is permitted.

Abstract: A hair styling and drying apparatus has a pair of pivotally connected arms, styling surfaces on the arms, air suction and discharge orifices in the styling surfaces, and a blower for blowing air through the air orifices and recycling air between the arms. At least some suction orifices of one styling surface can align with at least some discharge orifices of the other styling surface. The blowers blow air out the discharge orifices and suck air into the suction orifices, thereby recycling much of the blown air. The apparatus can include heaters for heating the blown air and for heating the styling surfaces.

Abstract: Disclosed are methods and systems for providing a constraint-driven environment for implementing a physical design of an electronic circuit with automatic snapping. In some embodiments, the method identifies or creates an incomplete layout. The method identifies an object and constraints for the object. The method then identifies an approximate position for the object in the layout and automatically snaps the object to a drop location based on the approximate position while complying with relevant constraint(s). The method may further align an object with another object with some spacing in between in some embodiments. The method may also perform automatic layer-to-layer snapping between two sets of objects such as cell instances, each having at least one object on multiple layers.

Abstract: Disclosed are methods and systems for providing a constraint-driven environment for implementing a physical design of an electronic circuit with automatic snapping. In some embodiments, the method identifies or creates an incomplete layout. The method identifies an object and constraints for the object. The method then identifies an approximate position for the object in the layout and automatically snaps the object to a drop location based on the approximate position while complying with relevant constraint(s). The method may further align an object with another object with some spacing in between in some embodiments. The method may also perform automatic layer-to-layer snapping between two sets of objects such as cell instances, each having at least one object on multiple layers.

Abstract: A hair styling and drying apparatus has a pair of pivotally connected arms, styling surfaces on the arms, air suction and discharge orifices in the styling surfaces, and a blower for blowing air through the air orifices and recycling air between the arms. At least some suction orifices of one styling surface can align with at least some discharge orifices of the other styling surface. The blowers blow air out the discharge orifices and suck air into the suction orifices, thereby recycling much of the blown air. The apparatus can include heaters for heating the blown air and for heating the styling surfaces.

Abstract: A transfer switch including: a bus bar; a track parallel to the bus bar; a first power source connection proximate to the track; a second power source connection proximate to the track offset along the track from the first power source connection; a conductive core slidably coupled to the track, wherein the core includes a deformable array of conductive sections and the array includes contacting surfaces on opposite sides of the array; wherein the conductive core has a first position providing a conductive coupling between the bus bar and the first power source and a second position providing a conductive coupling between the bus bar and the second power source.

Abstract: The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.

Abstract: A gearless transmission mechanism includes a plurality of identical linkages, each having an off-center center of rotation, an input end and an output end. The linkages being connected to each other such that the input end of one linkage is connected to the output end of another linkage. When force is applied to the input end of one linkage an output force results in the output end of the other linkage, which is not connected thereby resulting in force reduction.

Abstract: Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

Abstract: The invention provides novel substituted phenylamino isonicotinamide compounds (I), pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined in the specification. Said compounds are MEK inhibitors useful in the treatment of hyperproliferative diseases related to the hyperactivity of MEK, such as restenosis, as well as diseases modulated by the MEK cascade, such as cancer and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.

Abstract: A lamp includes a dichroic filter, a light emitting diode, and a lampshade. The light emitting diode emits light towards the dichroic filter. One portion of the light within a predetermined frequency range passes through the dichroic filter. The other portion of the light is refracted by the dichroic filter. The lampshade is used for shading the light. Therefore, the lampshade shows two colors of light.