Patents by Inventor Heribert Schmitt-Willich

Heribert Schmitt-Willich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma-carboline compounds for the detection of Tau aggregates
    Patent number: 11306089
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: April 19, 2022
    Assignee: LIFE MOLECULAR IMAGING LIMITED
    Inventors: Mathias Berndt, Andre Müller, Felix Oden, Hanno Schieferstein, Heribert Schmitt-Willich, Heiko Kroth, Jérôme Molette
  • GAMMA-CARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210047321
    Abstract: The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 18, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE
  • AZACARBOLINE COMPOUNDS FOR THE DETECTION OF TAU AGGREGATES
    Publication number: 20210041447
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging. The present invention also discloses intermediates which are useful in the preparation of these compounds.
    Type: Application
    Filed: January 22, 2019
    Publication date: February 11, 2021
    Inventors: Mathias BERNDT, Andre MÜLLER, Felix ODEN, Hanno SCHIEFERSTEIN, Heribert SCHMITT-WILLICH, Heiko KROTH, Jérôme MOLETTE, Emanuele GABELLIERI, Cédric BOUDOU
  • Compounds for imaging Tau protein aggregates
    Patent number: 10865207
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 15, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden
  • Compounds for imaging Tau protein aggregates
    Patent number: 10835624
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 17, 2020
    Assignees: AC IMMUNE S.A., LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
  • Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
    Patent number: 10662193
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 26, 2020
    Assignees: AC IMMUNE SA, LIFE MOLECULAR IMAGING SA
    Inventors: Heiko Kroth, Sreenivasachary Nampally, Jér{hacek over (o)}me Molette, Emanuele Gabellieri, Pascal André René Benderitter, Wolfgang Froestl, Hanno Schieferstein, Andre Mueller, Heribert Schmitt-Willich, Mathias Berndt
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190263817
    Abstract: The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jerome MOLETTE, Hanno SCHIEFERSTEIN, Andre MULLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN
  • COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
    Publication number: 20190262480
    Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 29, 2019
    Inventors: Heiko KROTH, Jérôme MOLETTE, Vicent DARMENCY, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT, Felix ODEN, Emanuele GABELLIERI
  • NOVEL IMAGING COMPOUNDS
    Publication number: 20180264146
    Abstract: The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
    Type: Application
    Filed: July 15, 2016
    Publication date: September 20, 2018
    Applicants: AC IMMUNE S.A., PIRAMAL IMAGING SA
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Hanno SCHIEFERSTEIN, Andre MÜLLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins
    Publication number: 20170002005
    Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.
    Type: Application
    Filed: January 21, 2015
    Publication date: January 5, 2017
    Inventors: Heiko KROTH, Sreenivasachary NAMPALLY, Jérôme MOLETTE, Emanuele GABELLIERI, Pascal André René BENDERITTER, Wolfgang FROESTL, Hanno SCHIEFERSTEIN, Andre MUELLER, Heribert SCHMITT-WILLICH, Mathias BERNDT
  • [F-18]-labelled L-glutamic acid and L-glutamine derivatives (I), their use and processes for their preparation
    Patent number: 9308282
    Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: April 12, 2016
    Assignee: PIRAMAL IMAGING SA
    Inventors: Matthias Friebe, Heribert Schmitt-Willich, Matthias Berndt, Ludger Dinkelborg, Norman Koglin, Keith Graham
  • Radiolabeled amino acids for diagnostic imaging
    Patent number: 9238631
    Abstract: This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogs thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 19, 2016
    Assignee: PIRAMAL IMAGING SA
    Inventors: Mathias Berndt, Andre Muller, Heribert Schmitt-Willich, Timo Stellfeld, Georg Kettschau, Thomas Brumby, Keith Graham, Lutz Lehmann, Jorma Haβfeld, Martin Kruger
  • BIS AZAINOSITOL HEAVY METAL COMPLEXES FOR X-RAY IMAGING
    Publication number: 20150132229
    Abstract: The present invention describes a new class of trinuclear heavy metal complexes comprising two hexadentate azainositol tricarboxylic acid ligands, a method for their preparation and their use as X-ray contrast agents.
    Type: Application
    Filed: April 25, 2013
    Publication date: May 14, 2015
    Inventors: Markus Berger, Heribert Schmitt-Willich, Detlev Sülzle, Hubertus Pietsch, Thomas Frenzel, Gregor Jost, Kaspar Hegetschweiler, Christian Neis, Silvia Lauria
  • Homoglutamic acid derivatives
    Patent number: 9017645
    Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: April 28, 2015
    Assignee: Piramal Imaging SA
    Inventors: Heribert Schmitt-Willich, Niels Böhnke, Norman Koglin, Andre Müller, Mathias Berndt, Matthias Friebe, Lutz Lehmann
  • Precursors of glutamate derivatives
    Patent number: 9000037
    Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: April 7, 2015
    Assignee: Piramal Imaging SA
    Inventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
  • RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING
    Publication number: 20150011773
    Abstract: This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
    Type: Application
    Filed: April 30, 2012
    Publication date: January 8, 2015
    Applicant: PIRAMAL IMAGING SA
    Inventors: Mathias Berndt, Andre Muller, Heribert Schmitt-Willich, Timo Stellfeld, Georg Kettschau, Thomas Brumby, Keith Graham, Lutz Lehmann, Jorma Hassfeld, Martin Kruger
  • NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES
    Publication number: 20140243532
    Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.
    Type: Application
    Filed: April 30, 2012
    Publication date: August 28, 2014
    Applicant: PIRAMAL IMAGING SA
    Inventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
  • L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVE (III), USE THEREOF AND METHOD FOR OBTAINING THEM
    Publication number: 20140227191
    Abstract: The present invention relates to fluorinated glutamic acid (glutamate) and glutamine derivatives wherein the fluorine atom is 19F. The glutamic acid (glutamate) and glutamine derivatives are compound(s) of general Formula I, which encompasses all possible diastereoisomers and/or enantiomere derivatives or mixtures thereof.
    Type: Application
    Filed: April 21, 2014
    Publication date: August 14, 2014
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Ludger DINKELBORG, Heribert SCHMITT-WILLICH, Keith GRAHAM, Norman KOGLIN, Mathias BERNDT, Matthias FRIEBE, Andre MULLER
  • NOVEL [F-18]-LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), THEIR USE AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20140154183
    Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Inventors: Matthias FRIEBE, Heribert SCHMITT-WILLICH, Matthias BERNDT, Ludger DINKELBORG, Norman KOGLIN, Keith GRAHAM
  • METHOD FOR PRODUCTION OF F-18 LABELED GLUTAMIC ACID DERIVATIVES
    Publication number: 20130149243
    Abstract: This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.
    Type: Application
    Filed: November 6, 2010
    Publication date: June 13, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Mathias Berndt, Heribert Schmitt-Willich, Matthias Friebe, Keith Graham, Thomas Brumby, Christina Hultsch, Hans-Jürgen Wester, Franziska Wagner