Patents by Inventor Hidefumi Yukimasa
Hidefumi Yukimasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080153801Abstract: This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.Type: ApplicationFiled: November 19, 2007Publication date: June 26, 2008Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
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Publication number: 20070117787Abstract: This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering triglyceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.Type: ApplicationFiled: December 12, 2006Publication date: May 24, 2007Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
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Publication number: 20040072819Abstract: This invention provides new benzoxazepine compounds represented by the formula: 1Type: ApplicationFiled: June 24, 2003Publication date: April 15, 2004Applicant: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
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Patent number: 6613761Abstract: This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.Type: GrantFiled: June 6, 2000Date of Patent: September 2, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
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Patent number: 6110909Abstract: This invention provides new benzoxazepine compounds represented by the formula: ##STR1## [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R.sub.1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.Type: GrantFiled: March 12, 1998Date of Patent: August 29, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Yasuo Sugiyama, Ryuichi Tozawa
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Patent number: 5885979Abstract: N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.Type: GrantFiled: May 7, 1997Date of Patent: March 23, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Masakuni Kori, Kazuaki Kitano, Yasuo Sugiyama
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Patent number: 5840917Abstract: A phosphorylamide derivative represented by the general formula (I): ##STR1## wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.Type: GrantFiled: December 6, 1996Date of Patent: November 24, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoru Oi, Hideaki Nagaya, Nobuhiro Inatomi, Masafumi Nakao, Hidefumi Yukimasa
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Patent number: 5726306Abstract: N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.Type: GrantFiled: November 9, 1994Date of Patent: March 10, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Masakuni Kori, Kazuaki Kitano, Yasuo Sugiyama
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Patent number: 5698691Abstract: Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula ##STR1## wherein R.sub.1 is hydrogen or an optionally substituted hydrocarbon group; R.sub.2 is hydrogen, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic ring group; X' is a substituent comprising an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; Ring A is an optionally substituted benzene ring or an optionally substituted aromatic heterocyclic ring; Ring J' is a 7- to 8-membered heterocyclic ring containing at most three ring constituting hetero atoms; D is C or N; the Ring J' optionally having, besides R.sub.1, R.sub.Type: GrantFiled: September 26, 1994Date of Patent: December 16, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Hidefumi Yukimasa, Ryuichi Tozawa, Yasuo Sugiyama, Masakuni Kori
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Patent number: 5677298Abstract: Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) ##STR1## wherein R.sub.1 stands for H or an optionally substituted hydrocarbon group; R.sub.2 and R.sub.3 independently stand for H, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic group; Z stands for a carbon chain containing a double bond or --Z'--C(OH)-- (Z' stands for a bond or a straight-chain or branched alkylene chain); the symbol .........Type: GrantFiled: August 13, 1996Date of Patent: October 14, 1997Assignee: Takeda Chemical IndustriesInventors: Hidefumi Yukimasa, Masakuni Kori, Ryuichi Tozawa, Yasuo Sugiyama
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Patent number: 5580883Abstract: A compound useful for central antioxidant having inhibitory activity of degeneration and necrocytosis of cerebral cells of the formula (I): ##STR1## wherein A and B are independently (1) a group of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are independently hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted heterocyclic group, or R.sub.1 together with R.sub.2 and the nitrogen atom to which they are bound may form a cyclic amino group, provided that both R.sub.1 and R.sub.2 are not hydrogen atom at the same time, or (2) a group of the formula: ##STR3## wherein D is O or S, R.sub.3 is hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group, m is 1, 2, or 3 and n is 0, 1, 2, 3 or 4;p is 1 or 2, provided that both A may be the same or different when p is 2; andR.sub.4, R.sub.5 and R.sub.6 are independently hydrogen atom, a lower alkyl or a lower alkoxy, or R.sub.5 and R.sub.6 may bond together to form --CH.dbd.CH--CH.dbd.Type: GrantFiled: June 28, 1994Date of Patent: December 3, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Hidefumi Yukimasa, Masaomi Miyamoto
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Patent number: 5441967Abstract: 1. A cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, .sub.-- means either a single bond or a double bond (provided that when A means a bond, .sub.-- means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof.The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.Type: GrantFiled: December 22, 1993Date of Patent: August 15, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Hidefumi Yukimasa, Tetsuji Imamoto
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Patent number: 5294625Abstract: 1. A cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, --means either a single bond or a double bond (provided that when A means a bond, --means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof.The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.Type: GrantFiled: December 18, 1992Date of Patent: March 15, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Hidefumi Yukimasa, Tetsuji Imamoto
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Patent number: 5177087Abstract: There is provided a cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, means either a single bond or a double bond (provided that when A means a bond, means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof.The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.Type: GrantFiled: January 4, 1990Date of Patent: January 5, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Hidefumi Yukimasa, Tetsuji Imamoto