Abstract: A non-human animal that produces human tissue factor (TF) without substantially producing non-human animal tissue factor, said animal having a genome in which cDNA encoding human TF has been inserted upstream of the translation initiation codon for the non-human animal genomic TF gene.

Abstract: A substrate processing apparatus injects gas from an injection port formed on a shielding surface of an atmosphere shielding part and sucks a substrate by Bernoulli effect. The substrate is sucked in a state coming into contact with a contact supporting surface of a support member provided on the atmosphere shielding part, and rotated with the upper surface shielded by a shielding surface of the shielding part. A solution supply part supplies a chemical solution to the lower surface of the substrate. Therefore, mist of a processing solution or the processing solution can be reliably prevented from reaching the upper surface of the substrate. Thus provided is a substrate processing apparatus capable of reliably preventing the mist of the processing solution or the processing solution from reaching the upper surface of the substrate.

Abstract: A center robot is fixed approximately in a central portion of a process part. A coating unit, a drying unit, a transfer unit, a peeling unit, a film supplying unit and a reversing unit are arranged around the center robot. The center robot comprises a hand-for-substrate and a hand-for-film which are allowed to directly access the respective units. Within a process part, the center robot transports a sheet film and/or a substrate between the coating unit, the drying unit, the transfer unit and the film supplying unit, and a thin film is formed on the substrate using the sheet film.

Abstract: A circuitry is provided with a first switching contact. A first spacer is laminated on the circuitry so as to provide a first space above the first switching contact. A first, elastic sheet member is laminated on the first spacer and provided with a second switching contact opposing to the first switching contact in the first space. The first sheet member is operable to deform while using the first space to bring the second switching contact into an electrical contact with the first switching contact. A second spacer is laminated on the first sheet member so as to provide a second space above a first part of the first sheet member. A second sheet member is laminated on the second spacer, the second sheet member being operable to deform while using the second space to thereby deform the first part of the first sheet member. An elastic member is interposed between the first sheet member and the second sheet member at the second space.

Abstract: In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method wherein a common detection marker is utilized for separately detecting the presence or absence of each of the biological activities. The present inventors discovered that a compound having at least one of two or more distinct biological activities can be efficiently and conveniently detected by simultaneously assaying at least one test sample or more by the above-mentioned method. Furthermore, for a test sample that proved to be positive by the detection method, they found that it is possible to efficiently and conveniently screen for a test sample having an objective specific biological activity by combining with a method wherein an individual activity of a test sample can be detected to specify the biological activity.

Abstract: The slip ring device (10) includes stationary and rotary members (11, 20) rotatable to each other. The slip ring device includes a sliding contact system for electrically interconnecting the stationary and rotary members. The sliding contact system includes slip rings (30, 31) with sliding faces (34a, 35a) mounted to one of the stationary and rotary members. The slip rings are separated from each other, with the sliding faces facing each other. The sliding contact system includes sliding contact members (17, 18) mounted to the other of the stationary and rotary members. Each of the sliding contact members slidably contact with each of the sliding faces.

Abstract: A humanized antibody against tissue factor (TF), comprising:

Abstract: A circuitry is provided with a first switching contact. A first spacer is laminated on the circuitry so as to provide a first space above the first switching contact. A first, elastic sheet member is laminated on the first spacer and provided with a second switching contact opposing to the first switching contact in the first space. The first sheet member is operable to deform while using the first space to bring the second switching contact into an electrical contact with the first switching contact. A second spacer is laminated on the first sheet member so as to provide a second space above a first part of the first sheet member. A second sheet member is laminated on the second spacer, the second sheet member being operable to deform while using the second space to thereby deform the first part of the first sheet member. An elastic member is interposed between the first sheet member and the second sheet member at the second space.

Abstract: The present invention relates to a human/mouse chimeric antibody that includes the variable region of a mouse monoclonal antibody against human tissue factor (TF) and the constant region of a human antibody. The humanized antibody contains light and heavy chain complementarity determining regions of a mouse monoclonal antibody against human TF which have been grafted onto a human antibody. The present invention also provides a therapeutic agent for disseminated intravascular coagulation (DIC) syndrome, which includes a humanized antibody against human TF as an active ingredient.

Abstract: A support member of a rotary base member engages with a substrate for preventing the substrate from horizontal movement and rotation with respect to the rotary base member while allowing vertical movement of the substrate, and a proximity suction plate is provided above the rotary base member so that the lower surface thereof is formed on a plane on the rotary base member parallel to the substrate for downwardly and outwardly injecting gas toward the overall upper surface of the substrate and sucking the substrate in a proximity state by Bernoulli effect. It is possible to provide an apparatus capable of reliably preventing mist of a processing solution or the processing solution from reaching the upper surface of the substrate when rotating the substrate and supplying the processing solution to the lower surface for processing the substrate.

Abstract: The slip ring device (10) includes stationary and rotary members (11, 20) rotatable to each other. The slip ring device includes a sliding contact system for electrically inter connecting the stationary and rotary members. The sliding contact system includes slip rings (30, 31) with sliding faces (34a, 35a) mounted to one of the stationary and rotary members. The slip rings are separated from each other, with the sliding faces facing each other. The sliding contact system includes sliding contact members (17, 18) mounted to the other of the stationary and rotary members. Each of the sliding contact members slidably contact with each of the sliding faces.

Abstract: A substrate processing apparatus injects gas from an injection port formed on a shielding surface of an atmosphere shielding part and sucks a substrate by Bernoulli effect. The substrate is sucked in a state coming into contact with a contact supporting surface of a support member provided on the atmosphere shielding part, and rotated with the upper surface shielded by a shielding surface of the shielding part. A solution supply part supplies a chemical solution to the lower surface of the substrate. Therefore, mist of a processing solution or the processing solution can be reliably prevented from reaching the upper surface of the substrate. Thus provided is a substrate processing apparatus capable of reliably preventing the mist of the processing solution or the processing solution from reaching the upper surface of the substrate.

Abstract: In a connecting structure, an end portion (11A) of a flexible flat cable (FFC) (11), including a plurality of parallel connectors (12) held between base films (13 and 14), is joined by soldering to wiring terminal patterns (16) formed on a surface of a wiring board (15). The lower covering film (13), which is to be joined to the wiring terminal patterns (16) at the end portion (11A) of the FFC (11), is removed over a length corresponding to a region of soldering levelers (18) formed respectively on the wiring terminal patterns (16). The upper covering film (14) is removed at the end portion (11A) over a region closer to the end of the flat circuit member (11) than an end of the lower covering film (13), and covers part of the wiring terminal patterns (16).

Abstract: A protein having activities of a human platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (I) or an amino acid sequence having homology therewith; and a DNA encoding the protein: 1 Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser Leu Gln Glu Glu Trp Ile Pro Phe Arg Ar

Abstract: The color determination circuit 308 detects hue of the color image information, and the controller 205 decides a color component to be separated (separation color) in accordance with the detected hue. Output color by the printer 204 is set in correspondence with the separation color. The two-color-separating circuit 303 separates the color image information into image information on at least two color components in accordance with the decided separation colors. The separated image information on the each color is transmitted to the printer 204 via printer density correction circuits 304 and 305, and a buffer 306. Thereby it is possible to provide an image processing apparatus capable of setting and changing the separation color and the output color by automatic operation or by simple manual operation, thus the expression of the image forming can be improved.

Abstract: A support member of a rotary base member engages with a substrate for preventing the substrate from horizontal movement and rotation with respect to the rotary base member while allowing vertical movement of the substrate, and a proximity suction plate is provided above the rotary base member so that the lower surface thereof is formed on a plane on the rotary base member parallel to the substrate for downwardly and outwardly injecting gas toward the overall upper surface of the substrate and sucking the substrate in a proximity state by Bernoulli effect. It is possible to provide an apparatus capable of reliably preventing mist of a processing solution or the processing solution from reaching the upper surface of the substrate when rotating the substrate and supplying the processing solution to the lower surface for processing the substrate.

Abstract: A first cable conductor portion is placed on a first connector terminal. The first cable conductor portion is accommodated in a pressing recessed portion formed in an applying member. Ultrasonic vibration is applied to the first cable conductor portion and the first connector terminal and the first cable conductor portion and the first connector terminal are pressed, and thereby to be welded to each other.

Abstract: A first cable conductor portion is placed on a first connector terminal. The first cable conductor portion is accommodated in a pressing recessed portion formed in an applying member. Ultrasonic vibration is applied to the first cable conductor portion and the first connector terminal and the first cable conductor portion and the first connector terminal are pressed, and thereby to be welded to each other.

Abstract: A cable holding structure is adapted so that a bent portion (13a) of a flexible flat cable (13) is held by a rotator (11). In this structure, a groove-like holder portion (19), into which the bent portion (13a) is inserted, is formed in the rotator (11). A slit (19a), into which a flexible flat cable (13) extending in one direction X is inserted from the bent portion (13a), and an opening portion (19b), into which another cable (13) extending in another direction Y is inserted from the bent portion (13a), are formed in this holder portion (19). A stopper (19c) abutting against a side edge portion (13b) of the cable (13), which extends in the latter direction Y, is provided on the surface of the slit (19a). A slip-off preventing projection (21) abutting against an upper side edge portion (13c) of the cable (13), which extends in the one direction X, from the bent portion (13a) is provided on the surface of the opening portion (19b).

Abstract: In a connecting structure, an end portion (11A) of a FFC (11), including a plurality of parallel conductors (12) held between base films (13 and 14), is joined by soldering to wiring terminal patterns (16) formed on a surface of a wiring board (15). The lower covering film (13), which is to be joined to the wiring terminal patterns (16) at the end portion (11A) of the FFC (11), is removed over a length corresponding to a region of soldering levelers (18) formed respectively on the wiring terminal patterns (16). The upper covering film (14) is removed at the end portion (11A) over a region closer to the end of the flat circuit member (11) than an end of the lower covering film (13), and covers part of the wiring terminal patterns (16).