Patents by Inventor Hideki Hasegawa
Hideki Hasegawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11955149Abstract: In general, according to one embodiment, a disk device includes a magnetic disk, a magnetic head, a suspension, a ramp, a housing, and a screw. The suspension holds the magnetic head and moves to an unload position. The ramp includes an attachment tab with a through hole. The ramp holds the suspension at the unload position. The housing has a support surface with a screw hole to support the attachment tab. The screw includes a screw head, a screw shaft, and a first contact surface. The screw shaft extends from the screw head in a first direction and is fitted into the screw hole through the through hole. The first contact surface is located on the screw head, tapers in the first direction, and contacts the attachment tab. The screw holds the attachment tab in-between the support surface and the first contact surface.Type: GrantFiled: March 7, 2023Date of Patent: April 9, 2024Assignees: Kabushiki Kaisha Toshiba, Toshiba Electronic Devices & Storage CorporationInventors: Hisashi Hasegawa, Hideki Yamaguchi, Sinji Tukada
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Publication number: 20240096353Abstract: In general, according to one embodiment, a disk device includes a magnetic disk, a magnetic head, a suspension, a ramp, a housing, and a screw. The suspension holds the magnetic head and moves to an unload position. The ramp includes an attachment tab with a through hole. The ramp holds the suspension at the unload position. The housing has a support surface with a screw hole to support the attachment tab. The screw includes a screw head, a screw shaft, and a first contact surface. The screw shaft extends from the screw head in a first direction and is fitted into the screw hole through the through hole. The first contact surface is located on the screw head, tapers in the first direction, and contacts the attachment tab. The screw holds the attachment tab in-between the support surface and the first contact surface.Type: ApplicationFiled: March 7, 2023Publication date: March 21, 2024Inventors: Hisashi HASEGAWA, Hideki YAMAGUCHI, Sinji TUKADA
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Publication number: 20240055249Abstract: Provided is a technique for realizing high analysis reproducibility. An ion source of the present disclosure includes a capillary and a gas spray tube into which the capillary is inserted, the gas spray tube spraying a gas to an outer side of the capillary, and the gas spray tube having a deflection site, which deflects a downstream end of the capillary with respect to a central axis of a tip hole of the gas spray tube, on an upstream side of the tip hole of the gas spray tube.Type: ApplicationFiled: October 25, 2021Publication date: February 15, 2024Applicant: HITACHI HIGH-TECH CORPORATIONInventors: Hideki HASEGAWA, Masuyuki SUGIYAMA
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Patent number: 11860142Abstract: A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths that analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.Type: GrantFiled: October 25, 2019Date of Patent: January 2, 2024Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa
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Patent number: 11749517Abstract: An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG. 4).Type: GrantFiled: October 10, 2019Date of Patent: September 5, 2023Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hideki Hasegawa, Masuyuki Sugiyama, Yuichiro Hashimoto
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Publication number: 20230167199Abstract: Provided is a method for producing trimeric and tetrameric IgA antibodies, the method including mixing dimeric IgA antibodies and monomeric IgA antibodies.Type: ApplicationFiled: March 22, 2021Publication date: June 1, 2023Inventors: Taizou KAMISHITA, Koshiro TABATA, Tadaki SUZUKI, Hideki HASEGAWA
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Publication number: 20230170198Abstract: A mass spectrometer includes an ion source, an ion guide, a quadrupole mass filter, a detector, DC and RF power sources, and a voltage control device for controlling an acceleration voltage by controlling the power source. The voltage controller controls the acceleration voltage such that it is increased as the mass-to-charge ratio of ions to be measured is increased within a control region. The control region is surrounded, having one coordinate axis representing the mass-to-charge ratio of the ions passing the ion guide and another axis representing the acceleration voltage applied to the ion guide, by a line representing a lower limit of a stable region where the ions pass the ion guide stably, a line representing an ion mobility of the ions, an upper side representing an upper limit of the acceleration voltage, and a lower side representing a value at which the acceleration voltage is zero.Type: ApplicationFiled: March 23, 2021Publication date: June 1, 2023Applicant: Hitachi High-Tech CorporationInventors: Masuyuki SUGIYAMA, Hideki HASEGAWA, Yuki NAGAYA, Yuichiro HASHIMOTO, Hiroyuki YASUDA
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Publication number: 20230141083Abstract: There are provided an ion source that can accurately and efficiently grasp whether a tip end position on a capillary downstream side is proper and a control method therefor. An ion source according to an embodiment of the present invention measures an electric current generated due to the application of a voltage to a capillary by a power supply when a sample is not introduced into the capillary. When the electric current is within tolerance, the ion source outputs projection amount information expressing that the projection amount of the capillary is proper, and the ion source outputs the projection amount information expressing that the projection amount is improper when the projection amount is not within the tolerance.Type: ApplicationFiled: December 4, 2020Publication date: May 11, 2023Inventors: Hideki HASEGAWA, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO
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Publication number: 20230005730Abstract: Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.Type: ApplicationFiled: October 15, 2020Publication date: January 5, 2023Applicant: Hitachi High-Tech CorporationInventors: Hideki HASEGAWA, Masuyuki SUGIYAMA, Yuichiro HASHIMOTO
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Patent number: 11491219Abstract: The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.Type: GrantFiled: October 4, 2018Date of Patent: November 8, 2022Assignees: TOKYO YAKUHIN KOGYO CO., LTD., TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE, JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases, KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITYInventors: Taizou Kamishita, Takashi Miyazaki, Michinori Kohara, Takahiro Sanada, Yoichi Hiasa, Osamu Yoshida, Kyoko Kohara, Hideki Hasegawa
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Publication number: 20220050091Abstract: A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths and analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve, connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.Type: ApplicationFiled: October 25, 2019Publication date: February 17, 2022Inventors: Masuyuki Sugiyama, Yuichiro Hashimoto, Hideki Hasegawa
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Publication number: 20210358734Abstract: An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG. 4).Type: ApplicationFiled: October 10, 2019Publication date: November 18, 2021Inventors: Hideki Hasegawa, Masuyuki Sugiyama, Yuichiro Hashimoto
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Patent number: 11101121Abstract: For increasing a speed of fragmentation of a sample, such as a protein and a peptide, to enhance introduction efficiency into a detector, such as a mass spectrometer, a liquid feeding pump 2, a sample injector 3, and a separation column 6 that are connected via pipes are included, and further, a heating unit 4 for heating a pipe between the sample injector 3 and the separation column 6, and a pressure regulating unit 5 provided between the heating unit 4 and the separation column 6 for regulating the inner pressure of the pipe heated by the heating unit 4, are included.Type: GrantFiled: March 30, 2016Date of Patent: August 24, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hideki Hasegawa, Shun Kumano, Yuichiro Hashimoto
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Patent number: 10925962Abstract: Provided are: a polymeric IgA-type recombinant antibody; a medicine containing this polymeric IgA-type recombinant antibody as an active ingredient; a method for producing this polymeric IgA type antibody, the method including the step of coexpressing an IgA-type antibody heavy-chain protein, an antibody light-chain protein, an antibody J-chain protein, and a secretory component protein within a single cell; and a method for improving the antigen-binding activity or neutralizing activity of this antibody, the method including the step of making an antibody into a polymeric IgA-type.Type: GrantFiled: July 21, 2015Date of Patent: February 23, 2021Assignee: Nippi, IncorporatedInventors: Shinji Saito, Tadaki Suzuki, Hideki Hasegawa, Akira Ainai, Kiyoko Goto, Tomonori Ueno, Yuki Taga
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Patent number: 10921296Abstract: A separation column connecting device includes: a column holder for retaining a separation column; a first fitting holder carrying a first fitting which includes a seal portion to be connected to an upstream seal portion of the separation column and connected with an upstream pipe; a second fitting holder carrying a second fitting which includes a seal portion to be connected to a downstream seal portion of the separation column and connected with a downstream pipe; a body member to which either one of the first fitting holder and the second fitting holder is fixed; a driver for moving, relative to the body member, the first fitting holder or the second fitting holder not fixed to the body member; a guide for guiding the column holder in a direction of movement driven by the driver; and an elastic body disposed between the column holder and the second fitting holder.Type: GrantFiled: May 17, 2016Date of Patent: February 16, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hideki Hasegawa, Masako Ishimaru, Masuyuki Sugiyama
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Publication number: 20200261568Abstract: The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.Type: ApplicationFiled: October 4, 2018Publication date: August 20, 2020Inventors: Taizou KAMISHITA, Takashi MIYAZAKI, Michinori KOHARA, Takahiro SANADA, Yoichi HIASA, Osamu YOSHIDA, Kyoko KOHARA, Hideki HASEGAWA
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Patent number: 10684256Abstract: In order to make an analyzer with an ion mobility separation part have high durability and robustness, the analyzer includes an ion source, an ion mobility separation part which includes a pair of facing electrodes to which a high frequency voltage and a DC voltage are applied, and a shielding electrode which is provided between the ion source and the ion mobility separation part and to which a DC voltage is applied, wherein the shielding electrode includes an ion flow path connecting an inlet from which ions from the ion source are introduced and an outlet from which the ions are discharged thereinside, and the ion flow path is bent so that the outlet is unable to be seen from the inlet.Type: GrantFiled: February 28, 2017Date of Patent: June 16, 2020Assignee: Hitachi High-Tech CorporationInventors: Hiroyuki Satake, Kazushige Nishimura, Hideki Hasegawa, Masuyuki Sugiyama
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Patent number: 10551346Abstract: An ion analysis device includes: an ion source that ionizes an analyte in a liquid sample; an ion guide into which droplets and ions produced in the ion source are introduced, the ion guide having different outlets, one outlet being an ion outlet for the ions and the other outlet being a droplet outlet for the droplets; an ion analysis unit that analyzes ions ejected from the ion outlet; a droplet measurement unit that is placed on an axis of the droplet outlet, and measures the amount of droplets; and an analysis control section that compares the amount of droplets measured at the droplet measurement unit with a threshold.Type: GrantFiled: August 19, 2016Date of Patent: February 4, 2020Assignee: Hitachi High-Technologies CorporationInventors: Kazushige Nishimura, Masuyuki Sugiyama, Hideki Hasegawa, Yuichiro Hashimoto
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Publication number: 20200025727Abstract: A separation column connecting device includes: a column holder for retaining a separation column; a first fitting holder carrying a first fitting which includes a seal portion to be connected to an upstream seal portion of the separation column and connected with an upstream pipe; a second fitting holder carrying a second fitting which includes a seal portion to be connected to a downstream seal portion of the separation column and connected with a downstream pipe; a body member to which either one of the first fitting holder and the second fitting holder is fixed; a driver for moving, relative to the body member, the first fitting holder or the second fitting holder not fixed to the body member; a guide for guiding the column holder in a direction of movement driven by the driver; and an elastic body disposed between the column holder and the second fitting holder.Type: ApplicationFiled: May 17, 2016Publication date: January 23, 2020Inventors: Hideki HASEGAWA, Masako ISHIMARU, Masuyuki SUGIYAMA
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Patent number: 10466214Abstract: In order to implement a high-sensitivity mass spectrometry through an improvement in solvent removal efficiency during electrospray ionization and the like, an ionization device is provided with a light guide path 28 which guides light from a light source to sample microparticles generated by a micronization device to irradiate the microparticles. A closest distance d2 between a spatial area 34 in which the sample microparticles are present and a distal end 29 of the light guide path is greater than or equal to 0.1 mm and less than or equal to 20 mm. A closest distance d1 between an area of light irradiation 35 by the light guide path and any of a sample surface, a micronization device, and a sample holding unit that is the closest is greater than or equal to 0.01 mm and less than or equal to 10 mm.Type: GrantFiled: December 9, 2015Date of Patent: November 5, 2019Assignee: HITACHI, LTD.Inventors: Masako Ishimaru, Masao Kamahori, Masuyuki Sugiyama, Kazushige Nishimura, Hiroyuki Satake, Hideki Hasegawa