Patents by Inventor Hideki Nakashima

Hideki Nakashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220354875
    Abstract: The present invention relates to a pharmaceutical composition comprising a liquid composition containing p-boronophenylalanine, in which the liquid composition is accommodated in a packaging material and satisfies the following Condition I or Condition II: Condition I: the liquid composition comprises substantially no antioxidant and a concentration of dissolved oxygen in the liquid composition is 3.5 ppm or less; Condition II: the liquid composition comprises an antioxidant and a concentration of dissolved oxygen in the liquid composition is 3.0 ppm or less.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 10, 2022
    Applicant: STELLA PHARMA CORPORATION
    Inventors: Yoshiya IGUCHI, Yoshimitsu KATAKUSE, Hideki NAKASHIMA
  • Publication number: 20220296715
    Abstract: An object of the present invention is to provide a method for preventing precipitation by storing an injection solution for boron neutron capture therapy. The present invention provides a method for preventing precipitation of an injection solution for boron neutron capture therapy, the injection solution containing p-boronophenylalanine or a pharmaceutically acceptable salt thereof; a sugar alcohol; and a pH adjusting agent, having a pH of 6.5 to 8.0 and an osmotic pressure ratio of 1.0 to 1.8, and being to be administered by intravenous drip injection.
    Type: Application
    Filed: September 9, 2020
    Publication date: September 22, 2022
    Inventors: Yoshiya Iguchi, Yoshimitsu Katakuse, Hideki Nakashima
  • Publication number: 20220280540
    Abstract: An object of the present invention is to provide an injection solution for boron neutron capture therapy. Provided is an injection solution for boron neutron capture therapy, containing p-boronophenylalanine or a pharmaceutically acceptable salt thereof, with a ratio of boron 10 of boron atoms in a compound of 75% or more; a sugar alcohol; an antioxidant; and water, the injection solution having a pH of 6.5 to 7.8 and an osmotic pressure ratio of 1.0 to 1.8, the injection solution being to be administered by intravenous drip injection.
    Type: Application
    Filed: September 9, 2020
    Publication date: September 8, 2022
    Inventors: Yoshiya Iguchi, Yoshimitsu Katakuse, Hideki Nakashima
  • Patent number: 11256282
    Abstract: A control lever device of an industrial vehicle includes a control lever that is tiltable forward and rearward relative to a vehicle body of the industrial vehicle and that includes a control knob, a switch button that is provided on the control knob and adapted to be pushable while the control lever is operated. The switch button has a movement axis indicating a movable direction of the switch button. The movement axis is inclined forward relative to a direction orthogonal to an extending direction of the control knob so that a pushing direction of the switch button is directed rearward from the direction orthogonal to the extending direction of the control knob.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: February 22, 2022
    Assignee: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI
    Inventors: Kenichiro Kawaguchi, Hideki Nakashima, Kazushi Kamiya, Nobuaki Kawabata
  • Publication number: 20210004039
    Abstract: A control lever device of an industrial vehicle includes a control lever that is tiltable forward and rearward relative to a vehicle body of the industrial vehicle and that includes a control knob, a switch button that is provided on the control knob and adapted to be pushable while the control lever is operated. The switch button has a movement axis indicating a movable direction of the switch button. The movement axis is inclined forward relative to a direction orthogonal to an extending direction of the control knob so that a pushing direction of the switch button is directed rearward from the direction orthogonal to the extending direction of the control knob.
    Type: Application
    Filed: June 26, 2020
    Publication date: January 7, 2021
    Applicant: KABUSHIKI KAISHA TOYOTA JIDOSHOKKI
    Inventors: Kenichiro KAWAGUCHI, Hideki NAKASHIMA, Kazushi KAMIYA, Nobuaki KAWABATA
  • Patent number: 10344042
    Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 9, 2019
    Assignees: Stella Pharma Corporation, Osaka Prefecture University Public Corporation
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Patent number: 10005794
    Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 26, 2018
    Assignees: STELLA PHARMA CORPORATION, OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Patent number: 9815855
    Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: November 14, 2017
    Assignees: Stella Pharma Corporation, Osaka Prefecture University Public Corporation
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Publication number: 20170283441
    Abstract: The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, in which NR40R50 are together.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Publication number: 20170015684
    Abstract: 18F-labeled 4-boronophenylalanine (BPA) can be produced by preparing and further processing a precursor of 18F-labeled BPA represented by the following formula: in which R1 represents a bromo group, an iodo group, a fluoro group, a diazaborinane derivative, BX3? or BX3?M+ (wherein X represents a halogen atom; and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation).
    Type: Application
    Filed: January 28, 2015
    Publication date: January 19, 2017
    Inventors: Hiroshi TAKENAKA, Yoichiro OHTA, Yusuke TAGUCHI, Sayuri UEDA, Yuko ISHINO, Tomohiro YOSHIKAWA, Hideki NAKASHIMA, Kohki UEHARA, Mitsunori KIRIHATA
  • Publication number: 20160311836
    Abstract: The present invention involves preparing compounds represented by the formula. (In the formula: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C?N, wherein NR40R50 are together.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 27, 2016
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Tomohiro Yoshikawa, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Patent number: 9409926
    Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18F-2-fluoro-4-borono-L-phenylalanine (18F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR3R4, BX3? or BX3?M+ (wherein X represents a halogen atom, and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R1 represents a hydrogen atom or a protecting group PG1; R2 represents a hydrogen atom or a protecting group PG2; R3 and R4 independently represent OH, or R3, R4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO2, NH2, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18F-labeled BPA.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: August 9, 2016
    Assignee: STELLA PHARMA CORPORATION; OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION
    Inventors: Hiroshi Takenaka, Yoichiro Ohta, Yusuke Taguchi, Sayuri Ueda, Yuko Ishino, Hideki Nakashima, Kohki Uehara, Mitsunori Kirihata
  • Patent number: 9203106
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: December 1, 2015
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Tetsuo Nishida, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii
  • Publication number: 20150329564
    Abstract: Provided are: a novel chiral 4-boronophenylalanine (BPA) derivative; a method for producing the derivative; and a method for producing 18F-2-fluoro-4-borono-L-phenylalanine (18F-labeled BPA; 18F-BPA) using the derivative. A compound represented by formula (1) is prepared. In the formula, R represents BR3R4, BX3? or BX3?M+ (wherein X represents a halogen atom, and M+ represents a monovalent monoatomic cation, a polyatomic cation or a complex cation); R1 represents a hydrogen atom or a protecting group PG1; R2 represents a hydrogen atom or a protecting group PG2; R3 and R4 independently represent OH, or R3, R4 and B together form a ring that serves as a protecting group; and Y represents a halogen atom, NO2, NH2, Sn(R6)3, N?N—NR7R8, OSO2R9, NR10R11, a substituted or unsubstituted phenyliodo group or a substituted or unsubstituted heterocyclic iodo group. The compound is reacted with a fluorination reagent to prepare 18F-labeled BPA.
    Type: Application
    Filed: October 8, 2013
    Publication date: November 19, 2015
    Inventors: Hiroshi TAKENAKA, Yoichiro OHTA, Yusuke TAGUCHI, Sayuri UEDA, Yuko ISHINO, Hideki NAKASHIMA, Kohki UEHARA, Mitsunori KIRIHATA
  • Patent number: 9028786
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: May 12, 2015
    Assignees: Stella Chemifa Corporation, Mitsubishi Chemical Corporation
    Inventors: Tetsuo Nishida, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii
  • Patent number: 8293411
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: October 23, 2012
    Assignees: Stella Chemifa Corporation, Mitsubishi Chemical Corporation
    Inventors: Tetsuo Nishida, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii
  • Patent number: 8135381
    Abstract: According to one aspect of the invention, there is provided a mobile apparatus including: a sensor configured to detect acceleration applied to the mobile apparatus and to generate a detection signal; a memory configured to record count data based on the detection signal, the count data associated with movement of the mobile apparatus; a counting module configured to count the number of user's steps based on the count data; a sound module configured to sound; and a counting control module configured to control the counting module to stop counting of the number of user's steps when the sound module starts sounding.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: March 13, 2012
    Assignee: Fujitsu Toshiba Mobile Communications Limited
    Inventors: Kazuhiko Ikeda, Shiro Shimaoka, Hideki Nakashima, Noboru Imazawa
  • Publication number: 20110223488
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Application
    Filed: May 18, 2011
    Publication date: September 15, 2011
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Tetsuo Nishida, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii
  • Publication number: 20110223089
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Application
    Filed: May 23, 2011
    Publication date: September 15, 2011
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Tetsuo NISHIDA, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii
  • Publication number: 20110111288
    Abstract: To provide a technique for simply and easily producing a high-purity difluorophosphate and provide a production process of an electrolytic solution using the obtained difluorophosphate, an electrolytic solution and a secondary battery. A process for producing a difluorophosphate, comprising the following step (1) or (2): (1) reacting (A) at least one member selected from the group consisting of oxoacids, oxoacid anhydrides and oxyhalides of phosphorus with (B) a hexafluorophosphate in the presence of hydrogen fluoride, or (2) reacting at least one halide selected from the group consisting of alkali metal halides, alkaline earth metal halides, aluminum halides and onium halides with difluorophosphoric acid in the presence of a hexafluorophosphate. Also, a nonaqueous electrolytic solution containing the obtained difluorophosphate, and a nonaqueous electrolytic secondary battery containing the nonaqueous electrolytic solution.
    Type: Application
    Filed: December 1, 2009
    Publication date: May 12, 2011
    Applicants: STELLA CHEMIFA CORPORATION, MITSUBISHI CHEMICAL CORPORATION
    Inventors: Tetsuo Nishida, Megumi Tomisaki, Kazuhiko Shogami, Hideki Nakashima, Hirofumi Suzuki, Takashi Fujii