Patents by Inventor Hideo Nemoto

Hideo Nemoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8841284
    Abstract: There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) [where X is OR or NR1R2, Y is OH, NR3R4, —NHC(?NH)NHR5, or —NHC(?NH)R5, and Z is a hydrogen atom, a linear or branched C1-5 alkyl group, or a 5- or 6-membered ring aryl group optionally having 1 or 2 nitrogen atom(s), sulfur atom(s), or oxygen atom(s)], or a pharmaceutically or veterinary-medically acceptable salt of the compound.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: September 23, 2014
    Assignee: Lead Chemical Co., Ltd
    Inventors: Hideo Nemoto, Yuji Matsuya
  • Publication number: 20120190841
    Abstract: There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) [where X is OR or NR1R2, Y is OH, NR3R4, —NHC(?NH)NHR5, or —NHC(?NH)R5, and Z is a hydrogen atom, a linear or branched C1-5 alkyl group, or a 5- or 6-membered ring aryl group optionally having 1 or 2 nitrogen atom(s), sulfur atom(s), or oxygen atom(s)], or a pharmaceutically or veterinary-medically acceptable salt of the compound.
    Type: Application
    Filed: July 21, 2009
    Publication date: July 26, 2012
    Applicant: LEAD CHEMICAL CO., LTD.
    Inventors: Hideo Nemoto, Yuji Matsuya
  • Publication number: 20110021625
    Abstract: There is provided a neuronal cell death inhibitor having a high efficacy. A neuronal cell death inhibitor comprising a compound of general formula (1) below: (where R1 is a hydrogen atom or an optionally substituted hydroxy group; R2 is a hydrogen atom; R3 is a hydrogen atom or an optionally substituted hydroxy group; R4 is a hydrogen atom or an optionally substituted hydroxy group, R3 together with R4 is optionally an oxo group or a group of —O—(CH2)n—O— (where n is an integer of 2 to 4), or R2 together with R4 optionally forms an unsaturated bond between carbon atoms, the respective carbon atoms being attached to R2 and R4; R5 is a hydrogen atom or an optionally substituted lower alkyl group; each of R6, R7, and R8 is the same as or different from each other and is a hydrogen atom, an optionally substituted hydroxy group, an optionally substituted alkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group); or a salt thereof.
    Type: Application
    Filed: January 23, 2009
    Publication date: January 27, 2011
    Applicant: LEAD CHEMICAL CO., LTD.
    Inventors: Hideo Nemoto, Chihiro Tohda, Yuji Matsuya
  • Patent number: 7662852
    Abstract: An antiviral preparation comprising as an active ingredient, a phorbol derivative of formula 1: wherein is R1 is —(CH2)aX(CH2)bCH3, —(CH2)cX(CH2)dYCH3, —CO(CH2)eCH3 or —(CH2)fCH3 R2 is —CO(CH2)nCH3, R3, R4 and R5 are hydrogen atom, or an aliphatic or aromatic carboxylic acid residue, X and Y are O or S, and each of a-f and n is a number, and having a specific safety index S.I.=CC50/EC50 of 10 or more wherein EC50 means a concentration at which HIV-1 induced cytopathogenic effect (CPE) in MT-4 cell is inhibited by 50%, and CC50 means a concentration at which survival of MT-4 cell in a cell proliferation test is reduced by 50%. These preparations are particularly effective for human immuno-deficiency virus (HIV).
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: February 16, 2010
    Assignee: Lead Chemical Co., Ltd.
    Inventors: Masao Mori, Haruo Saito, Hideo Nemoto, Naoiki Yamamoto, Masao Hattori
  • Patent number: 7275574
    Abstract: Thermoplastic elastomer composition dynamically vulcanized with a 50 to 95% gelation rate has superior heat resistance, durability, and air permeation prevention, is flexible and usable as a pneumatic tire air permeation preventive layer. A composition having reduced domain rubber particle size is produced from a high rubber ratio material by mixing composition (C) under melt viscosities ratio of rubber composition (A)/resin (B) of 0.8 to 1.2 and formula (?A/?B)×(?B/?A)<1.0 under melt viscosities ratio of rubber composition (D)/composition (C) of 0.8 to 1.2 and formula (?D/?C)×(?C/?D)<1.0, wherein ?A, ?B, ?C and ?D are volume fractions of rubber composition (A) and resin (B), composition (C) and rubber composition (D), respectively, ?A ?B, ?C, and ?D are melt viscosities of rubber composition (A), resin (B), composition (C), and rubber composition (D), respectively.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: October 2, 2007
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Jiro Watanabe, Yuichi Hara, Shigeru Yamauchi, Hideo Nemoto
  • Patent number: 7265229
    Abstract: The present invention is a method for synthesizing macrosphelides represented by the following formula, and relates to the following method. The hydroxyl group of methyl 3-hydroxybutyrate is protected and reduced to alcohol. The alcohol is then oxidized to give 3-(tert-butyldimethylsilyloxy) butylaldehyde, and this aldehyde is then reacted with tert-butyl diethylphosphonoacetate to give an olefin, and then deprotected. Next, dehydrative condensation with diethylphosponoacetic acid are performed to give tert-butyl 5-[2-(diethylphosphonoyl) acetoxy] hex-2-enoate, and this compound is reacted with 3-(tert-butyldimethylsilyloxy) butylaldehyde to form a diester. Following this, deprotection is performed to give an alcohol, and dehydrative condensation of the alcohol with 3-(tert-butyldimethylsilyloxy) butyric acid gives a triester.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: September 4, 2007
    Assignee: Lead Chemical Co., Ltd.
    Inventors: Hideo Nemoto, Yu-ji Matsuya
  • Publication number: 20070066684
    Abstract: An antiviral preparation comprising as an active ingredient, a phorbol derivative of formula 1: wherein is R1 —(CH2)aX(CH2)bCH3, —(CH2)cX(CH2)dYCH3, —CO(CH2)eCH3 or —(CH2)fCH3 R2 is —CO(CH2)nCH3, R3, R4 and R5 are hydrogen atom, or an aliphatic or aromatic carboxylic acid residue, X and Y are O or S, and each of a-f and n is a number, and having a specific safety index S.I.=CC50/EC50 of 10 or more wherein EC50 means a concentration at which HIV-1 induced cytopathogenic effect (CPE) in MT-4 cell is inhibited by 50%, and CC50 means a concentration at which survival of MT-4 cell in a cell proliferation test is reduced by 50%. These preparations are particularly effective for human immuno-deficiency virus (HIV).
    Type: Application
    Filed: May 22, 2003
    Publication date: March 22, 2007
    Applicant: Lead Chemical Co., Ltd.
    Inventors: Masao Mori, Haruo Saito, Hideo Nemoto, Naoiki Yamamoto, Masao Hattori
  • Publication number: 20060030720
    Abstract: The present invention is a method for synthesizing macrosphelides represented by the following formula, and relates to the following method. The hydroxyl group of methyl 3-hydroxybutyrate is protected and reduced to alcohol. The alcohol is then oxidized to give 3-(tert-butyldimethylsilyloxy) butylaldehyde, and this aldehyde is then reacted with tert-butyl diethylphosphonoacetate to give an olefin, and then deprotected. Next, dehydrative condensation with diethylphosponoacetic acid are performed to give tert-butyl 5-[2-(diethylphosphonoyl) acetoxy] hex-2-enoate, and this compound is reacted with 3-(tert-butyldimethylsilyloxy) butylaldehyde to form a diester. Following this, deprotection is performed to give an alcohol, and dehydrative condensation of the alcohol with 3-(tert-butyldimethylsilyloxy) butyric acid gives a triester. A hydroxycarboxylic acid is yielded by deprotection, and then the hydroxycarboxylic acid is converted into a macrolactone.
    Type: Application
    Filed: November 26, 2002
    Publication date: February 9, 2006
    Inventors: Hideo Nemoto, Yu-Ji Matsuya
  • Publication number: 20050103417
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer. In particular, a thermoplastic elastomer composition having a reduced particle size of the domain rubber is produced by a material having a high rubber ratio by mixing a composition (C) mixed under conditions of a ratio of melt viscosities of the rubber composition (A)/resin (B) of 0.8 to 1.2 and the formula (?A/?B)×(?B/?A)<1.0 under conditions of a ratio of melt viscosities of the rubber composition (D)/composition (C) of 0.8 to 1.2 and the formula (?D/?C)×(?C/?D)<1.
    Type: Application
    Filed: December 13, 2004
    Publication date: May 19, 2005
    Inventors: Jiro Watanabe, Yuichi Hara, Shigeru Yamauchi, Hideo Nemoto
  • Patent number: 6861470
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer. The method includes mixing a composition (C) mixed under conditions of a ratio of melt viscosities of the rubber composition (A)/resin (B) of 0.8 to 1.2 and the formula (?A/?B)×(?B/?A)<1.0 under conditions of a ratio of melt viscosities of the rubber composition (D)/composition (C) of 0.8 to 1.2 and the formula (?D/?C)×(?C/?D)<1.0, wherein ?A: volume fraction of rubber composition (A), ?B: volume fraction of resin (B), ?A: melt viscosity of rubber composition (A), ?B: melt viscosity of resin (B), ?C: volume fraction of composition (C), ?D: volume fraction of rubber composition (D), ?C: melt viscosity of composition (C), ?D: melt viscosity of rubber composition (D).
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: March 1, 2005
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Jiro Watanabe, Kazuto Yamakawa, Daisuke Kanenari, Noriaki Kuroda, Gou Kawaguchi, Yuichi Hara, Tetsuji Kawazura, Shigeru Yamauchi, Hideo Nemoto
  • Publication number: 20030181592
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer. In particular, a thermoplastic elastomer composition having a reduced particle size of the domain rubber is produced by a material having a high rubber ratio by mixing a composition (C) mixed under conditions of a ratio of melt viscosities of the rubber composition (A)/resin (B) of 0.8 to 1.2 and the formula (&phgr;A/&phgr;B)×(&eegr;B/&eegr;A)<1.0 under conditions of a ratio of melt viscosities of the rubber composition (D)/composition (C) of 0.8 to 1.2 and the formula (&phgr;D/&phgr;C)×(&eegr;C/&eegr;D)<2.
    Type: Application
    Filed: January 21, 2003
    Publication date: September 25, 2003
    Applicant: THE YOKOHAMA RUBBER CO., LTD.
    Inventors: Jiro Watanabe, Yuichi Hara, Shigeru Yamauchi, Hideo Nemoto
  • Patent number: 6538066
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: March 25, 2003
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Jiro Watanabe, Kazuto Yamakawa, Daisuke Kanenari, Noriaki Kuroda, Gou Kawaguchi, Yuichi Hara, Tetsuji Kawazura, Shigeru Yamauchi, Hideo Nemoto
  • Patent number: 6359071
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer. In particular, a thermoplastic elastomer composition having a reduced particle size of the domain rubber is produced by a material having a high rubber ratio by mixing a composition (C) mixed under conditions of a ratio of melt viscosities of the rubber composition (A)/resin (B) of 0.8 to 1.2 and the formula (&phgr;A/&phgr;B)×(&eegr;B/&eegr;A)<1.0 under conditions of a ratio of melt viscosities of the rubber composition (D)/composition (C) of 0.8 to 1.2 and the formula (&phgr;D/&phgr;C)×(&eegr;C/&eegr;D)<1.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: March 19, 2002
    Assignee: The Yokohama Rubber Co., Ltd.
    Inventors: Jiro Watanabe, Kazuto Yamakawa, Daisuke Kanenari, Noriaki Kuroda, Gou Kawaguchi, Yuichi Hara, Tetsuji Kawazura, Shigeru Yamauchi, Hideo Nemoto
  • Publication number: 20010018492
    Abstract: A thermoplastic elastomer composition dynamically vulcanized to a gelation rate of 50 to 95% which is superior in heat resistance and durability while maintaining flexibility and superior in air permeation preventive property which can be efficiently used as, for example, a pneumatic tire as an air permeation preventive layer. In particular, a thermoplastic elastomer composition having a reduced particle size of the domain rubber is produced by a material having a high rubber ratio by mixing a composition (C) mixed under conditions of a ratio of melt viscosities of the rubber composition (A)/resin (B) of 0.8 to 1.2 and the formula (&phgr;A/&phgr;B)×(&eegr;B/&eegr;A)<1.0 under conditions of a ratio of melt viscosities of the rubber composition (D)/composition (C) of 0.8 to 1.2 and the formula (&phgr;D/&phgr;C)×(&eegr;C/&eegr;D)<1.
    Type: Application
    Filed: March 8, 2001
    Publication date: August 30, 2001
    Applicant: YOKOHAMA RUBBER CO., LTD.
    Inventors: Jiro Watanabe, Kazuto Yamakawa, Daisuke Kanenari, Noriaki Kuroda, Gou Kawaguchi, Yuichi Hara, Tetsuji Kawazura, Shigeru Yamauchi, Hideo Nemoto
  • Patent number: 5693629
    Abstract: A progesterone compound represented by the following formula (1): ##STR1## ?wherein R.sup.1 represents a C1-C23 hydrocarbon group!, and a neovascularization inhibitor containing the same as the active ingredient.The compound (1) has a potent neovascularization inhibitory effect and is hence useful in the treatment of malignant tumors, diabetic retinitis, rheumatism, etc.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: December 2, 1997
    Assignee: Meiji Milk Products Co., Ltd.
    Inventors: Satoshi Hibino, Eiichi Sugino, Tetsuya Kohno, Shiho Fujimori, Hideo Nemoto, Yoshitatsu Ichihara, Yoshio Sato
  • Patent number: 5640989
    Abstract: A fuel cut-off valve (10) includes an enlarged-diameter vapor outlet aperture (30) which is controlled by a first closure member (50) having a small auxiliary vapor vent orifice (52) which, in turn, is controlled by a second closure member (58) formed on the float member (38). The first closure member (50) is biased by a spring (62) toward the second closure member (58) to ensure that the first closure member (50) is unseated away from the main valve seat (36) as soon as the auxiliary vapor vent orifice (52) is opened.
    Type: Grant
    Filed: December 7, 1995
    Date of Patent: June 24, 1997
    Assignee: NOK Corporation
    Inventors: Hideo Nemoto, Koichi Yoshihara
  • Patent number: 4027936
    Abstract: A connector having electro-conductive rubber terminals is composed of an insulated casing having a plurality of recessed portions and a plurality of rubber terminal portions, of electro-conductive rubber inserted in respective ones of the recesses. The rubber terminals are connected together in rows to a runner and are inserted by rows into the recessed portions and then the terminals are cut from the runner whereby said terminal portions are attached to said insulated casing.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: June 7, 1977
    Assignee: Kabushiki Kaisha Daini Seikosha
    Inventors: Hideo Nemoto, Yuuji Koike