Patents by Inventor Hidetaka Nakayama
Hidetaka Nakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11273237Abstract: The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel.Type: GrantFiled: August 31, 2017Date of Patent: March 15, 2022Assignee: GUNZE LIMITEDInventors: Hidetaka Nakayama, Toshiharu Shinoka, Shuhei Tara, Tadahisa Sugiura
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Publication number: 20210283058Abstract: The present invention aims to provide a method for producing a sustained-release drug which includes allowing a medicinal ingredient to be supported on a porous body containing a bioabsorbable polymer and which can control the releasing rate of the medicinal ingredient. The present invention also aims to provide a sustained-release drug.Type: ApplicationFiled: August 31, 2017Publication date: September 16, 2021Inventor: Hidetaka NAKAYAMA
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Publication number: 20210283314Abstract: The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel.Type: ApplicationFiled: August 31, 2017Publication date: September 16, 2021Inventors: Hidetaka NAKAYAMA, Toshiharu SHINOKA, Shuhei TARA, Tadahisa SUGIURA
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Patent number: 10463469Abstract: The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.Type: GrantFiled: August 2, 2016Date of Patent: November 5, 2019Assignee: GUNZE LIMITEDInventors: Hidetaka Nakayama, Kosuke Sawai, Toshiharu Shinoka, Shuhei Tara, Hirotsugu Kurobe
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Publication number: 20180221132Abstract: The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.Type: ApplicationFiled: August 2, 2016Publication date: August 9, 2018Inventors: Hidetaka NAKAYAMA, Kosuke SAWAI, Toshiharu SHINOKA, Shuhei TARA, Hirotsugu KUROBE
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Publication number: 20160074023Abstract: There is provided a defect hole closing material which achieves minimally invasive medical treatment for Atrial Septal Defect, and poses little possibility of occurrence of a failure in the body in some distant future. The defect hole closing material (100) comprises two bioabsorbable material-made cylindrical bodies (the first cylindrical section (110) and the second cylindrical section (120)) having a mesh-like structure in the form of an hourglass shape, a numeral “8” shape, a double spindle shape, or a peanut shape. With the first end (112) kept held securely, the second end, or the other end (122) is pulled toward the first end (112) by operating the string (140), whereupon the cylinder diameter is increased, and also the first cylindrical section (110) and the second cylindrical section (120) move close to each other with respect to the substantially central section (130) serving as a center.Type: ApplicationFiled: April 22, 2014Publication date: March 17, 2016Applicant: GUNZE LIMITEDInventors: Yuki SAKAMOTO, Kensuke TAKI, Hidetaka NAKAYAMA, Noriko KAWADA
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Publication number: 20150111114Abstract: In a metal-air battery, a negative electrode, an electrolyte layer, and a positive electrode are concentrically disposed in the stated order, radially outward from the central axis, and the outer circumferential surface of the positive electrode is enclosed by a liquid-repellent layer (29). The liquid-repellent layer (29) includes a relatively high-strength inorganic porous material (292) having a continuous pore structure, and a fluorine-based porous part (293) formed by fusing fluorine-based particles to each other. The fluorine-based porous part (293) is fused to the inorganic porous material (292) in pores (294) of and on the outer surface (295) of the inorganic porous material (292). This makes it possible to provide the liquid-repellent layer (29) that is a functional porous material having desired mechanical strength, gas permeability, and liquid impermeability.Type: ApplicationFiled: April 22, 2013Publication date: April 23, 2015Applicant: HITACHI ZOSEN CORPORATIONInventors: Hidetaka Nakayama, Masanobu Aizawa, Takehiro Shimizu, Akira Taniguchi, Kazuya Kameyama, Yuki Nakamura, Yoshihiro Asari
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Patent number: 9011360Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.Type: GrantFiled: August 12, 2013Date of Patent: April 21, 2015Assignee: Terumo Kabushiki KaishaInventors: Norikazu Ishida, Hidetaka Nakayama
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Patent number: 8685320Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.Type: GrantFiled: May 20, 2010Date of Patent: April 1, 2014Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiro Mizoguchi
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Publication number: 20130331809Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.Type: ApplicationFiled: August 12, 2013Publication date: December 12, 2013Applicant: TERUMO KABUSHIKI KAISHAInventors: Norikazu ISHIDA, Hidetaka NAKAYAMA
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Patent number: 8517969Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.Type: GrantFiled: November 16, 2012Date of Patent: August 27, 2013Assignee: Terumo Kabushiki KaishaInventors: Norikazu Ishida, Hidetaka Nakayama
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Patent number: 8317738Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.Type: GrantFiled: January 16, 2009Date of Patent: November 27, 2012Assignee: Terumo Kabushiki KaishaInventors: Norikazu Ishida, Hidetaka Nakayama
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Patent number: 8142546Abstract: An artificial lung includes a housing, a tubular hollow fiber membrane bundle contained in the housing and providing a multiplicity of hollow fiber membranes having a gas exchange function, a gas inflow port and a gas outflow port communicating with each other through hollow portions of the hollow fiber membranes, and a blood inflow port and a blood outflow port through which blood is distributed. The tubular hollow fiber membrane bundle has a cylindrical overall shape, and a filter member having a bubble-trapping function is provided on an outer peripheral portion of the tubular hollow fiber membrane bundle.Type: GrantFiled: April 12, 2011Date of Patent: March 27, 2012Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama
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Publication number: 20110186514Abstract: An artificial lung includes a housing, a tubular hollow fiber membrane bundle contained in the housing and providing a multiplicity of hollow fiber membranes having a gas exchange function, a gas inflow port and a gas outflow port communicating with each other through hollow portions of the hollow fiber membranes, and a blood inflow port and a blood outflow port through which blood is distributed. The tubular hollow fiber membrane bundle has a cylindrical overall shape, and a filter member having a bubble-trapping function is provided on an outer peripheral portion of the tubular hollow fiber membrane bundle.Type: ApplicationFiled: April 12, 2011Publication date: August 4, 2011Applicant: TERUMO KABUSHIKI KAISHAInventors: Mitsuaki OGIHARA, Hidetaka Nakayama
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Patent number: 7947007Abstract: A bubble trap for removing bubbles from blood flowing through an extracorporeal circuit includes device body possessing blood inlet and outlet ports, and a negative-pressure chamber at the upper part of the device body that is adapted to be connected to a gas evacuator at a gas outlet port so that a negative-pressure state can be kept therein. Two communication passages provide communication between the gas outlet port and the device body. On the first communication passage, a liquid-repellant or water-repellent filter is provided in a manner crossing the passage. On the second communication passage, a valve member is arranged. Within the device body, a buoyant float is provided. A mechanism is provided to remove bubbles from the blood by the cooperation of the float and the valve member.Type: GrantFiled: April 9, 2007Date of Patent: May 24, 2011Assignee: Terumo Kabushiki KaishaInventors: Hidetaka Nakayama, Mitsuaki Ogihara, Kazuhiko Takeuchi
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Patent number: 7947113Abstract: An artificial lung includes a housing, a tubular hollow fiber membrane bundle contained in the housing and providing a multiplicity of hollow fiber membranes having a gas exchange function, a gas inflow port and a gas outflow port communicating with each other through hollow portions of the hollow fiber membranes, and a blood inflow port and a blood outflow port through which blood is distributed. The tubular hollow fiber membrane bundle has a cylindrical overall shape, and a filter member having a bubble-trapping function is provided on an outer peripheral portion of the tubular hollow fiber membrane bundle.Type: GrantFiled: September 8, 2008Date of Patent: May 24, 2011Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama
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Patent number: 7922683Abstract: An extracorporeal circulator comprising a line for extracting blood from a patient, a pump for supplying blood, an artificial lung section performing gas exchange on blood, a line for supplying blood passed through the artificial lung section to the patient, a unit for removing bubbles mixed into the blood, a controller for controlling the flow rate of blood being supplied such that bubbles are not fed to the patient, and a line for detouring blood delivered from the blood pump to return it to the blood pump.Type: GrantFiled: July 21, 2005Date of Patent: April 12, 2011Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiko Takeuchi, Yuki Ishikura, Akiyasu Ito
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Publication number: 20100224559Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.Type: ApplicationFiled: May 20, 2010Publication date: September 9, 2010Applicant: TERUMO KABUSHIKI KAISHAInventors: Mitsuaki OGIHARA, Hidetaka Nakayama, Kazuhiro Mizoguchi
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Patent number: 7749435Abstract: An oxygenator which helps avoid bubbles in the blood from being discharged through the blood outlet port of the oxygenator includes a housing, a hollow fiber membrane bundle in the housing and formed by a multiplicity of hollow fiber membranes serving for gas exchange, gas-inlet and gas-outlet ports communicating with gas passages of the hollow fiber membranes, and a blood-inlet and blood-outlet ports. A filter member is provided on a side closer to the blood outlet port of the hollow fiber membrane bundle and serves to catch bubbles in blood. The blood outlet port projects from the housing and a passage enlargement is provided in a vicinity of the end of the blood outlet port closer to the housing and having an increased passage cross-sectional area. The blood passed the filter member is allowed to reach the blood outlet port by being decelerated in the passage enlargement.Type: GrantFiled: January 19, 2007Date of Patent: July 6, 2010Assignee: Terumo Kabushiki KaishaInventors: Mitsuaki Ogihara, Hidetaka Nakayama, Kazuhiro Mizoguchi
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Publication number: 20090187132Abstract: A liquid collection bag is used as a part of an extracorporeal circuit and is connected via a tube to a storage container containing a priming solution. The collection container collects the priming solution from the storage container by a pressure differential between the pressure inside the collection container and the pressure inside the storage container. The liquid collection container is a flexible bag body having a partition part dividing the inside of the bag body into a first space and a second space. In addition, a communication part communicates the first space with the second space.Type: ApplicationFiled: January 16, 2009Publication date: July 23, 2009Applicant: TERUMO KABUSHIKI KAISHAInventors: Norikazu ISHIDA, Hidetaka Nakayama