Patents by Inventor Hideyuki HIYOSHI

Hideyuki HIYOSHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING BIOLOGICAL TISSUE-LIKE STRUCTURE
    Publication number: 20220168357
    Abstract: An object of the present invention is to provide a novel method for producing a biological tissue-like structure comprising differentiated cells induced from pluripotent stem cells, and the present invention provides a method of forming a biological tissue-like structure together with host-derived blood vessels and connective tissue by transplanting a composition in which cells derived from pluripotent stem cells are disposed to be dispersed in a biocompatible material to induce the differentiation of the cells.
    Type: Application
    Filed: April 9, 2020
    Publication date: June 2, 2022
    Applicant: Orizuru Therapeutics, Inc.
    Inventors: Hideyuki HIYOSHI, Taisuke MOCHIDA, Noriko YAMAZOE, Junji YAMAURA, Taro TOYODA, Shuhei KONAGAYA
  • INSULIN-PRODUCING CELLS
    Publication number: 20210353686
    Abstract: The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive cells in a ratio of at least 30% and cells that are insulin-positive and NKX6.1-negative in a ratio of more than 15%.
    Type: Application
    Filed: September 18, 2019
    Publication date: November 18, 2021
    Applicants: Takeda Pharmaceutical Company Limited, Kyoto University
    Inventors: Ryo ITO, Noriko YAMAZOE, Hideyuki HIYOSHI, Taisuke MOCHIDA, Hikaru UENO, Kensuke SAKUMA, Junji YAMAURA, Hirokazu MATSUMOTO, Taro TOYODA, Shuhei KONAGAYA
  • CELL PRODUCTION METHOD
    Publication number: 20210292708
    Abstract: An object of the present invention is to provide a novel approach that enables definitive endoderm cells or insulin-producing cells to be efficiently induced and/or manufactured from pluripotent stem cells. The present invention provides a method for producing definitive endoderm cells from pluripotent stem cells, comprising subjecting pluripotent stem cells to first culture in a differentiation-inducing medium in which insulin acts and subsequently to second culture in a differentiation-inducing medium in which insulin does not act.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 23, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Noriko YAMAZOE, Hideyuki HIYOSHI, Taro TOYODA
  • GROWTH INHIBITOR
    Publication number: 20210254014
    Abstract: The present invention relates to a method for producing an insulin-producing cell population or a pancreatic ? cell population having the reduced number of Ki67-positive cells, comprising treating a population of endocrine progenitor cells or cells at a later stage of differentiation with an FGFR1 inhibitor.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 19, 2021
    Applicants: Kyoto University, Takeda Pharmaceutical Company Limited
    Inventors: Noriko YAMAZOE, Hideyuki HIYOSHI, Taisuke MOCHIDA, Ryo ITO, Taro TOYODA, Azuma KIMURA