Patents by Inventor Hiroaki Nitta

Hiroaki Nitta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150287726
    Abstract: A semiconductor device includes a P-channel DMOS transistor provided with an N-type gate electrode, a P-channel MOS transistor provided with a P-type gate electrode, and an N-channel MOS transistor provided with an N-type gate electrode. The N-type gate electrode of the P-channel DMOS transistor desirably has a first end portion that is located on a source side of the P-channel DMOS transistor, a second end portion that is located on a drain side of the P-channel DMOS transistor, and a P-type diffusion layer at the first end portion.
    Type: Application
    Filed: March 26, 2015
    Publication date: October 8, 2015
    Inventors: Hiroaki NITTA, Hideyuki AKANUMA, Kazunobu KUWAZAWA
  • Patent number: 8481270
    Abstract: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: July 9, 2013
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Richard Gniewek, Michael Farrell, Hiroaki Nitta, Megan Lehrkamp, Jerome Kosmeder, Brian Daniel Kelly, Thomas Grogan, Fabien Gaire, Mary Padilla, Christopher Bieniarz
  • Patent number: 8330219
    Abstract: A semiconductor device includes: a semiconductor substrate having a first conductivity type; a well having a second conductivity type and provided inside the semiconductor substrate; a first impurity region having the first conductivity type and provided within the well; a second impurity region having the second conductivity type, provided inside the well and away from the first impurity region; and a third impurity region having a first conductivity type, provided surrounding the well and away from the second impurity region. In this semiconductor device, the well is formed to be deeper than the first impurity region, the second impurity region, and the third impurity region, in a thickness direction of the semiconductor substrate; and a minimum distance between the first impurity region and the second impurity region is smaller than a minimum distance between the second impurity region and the third impurity region.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: December 11, 2012
    Assignee: Seiko Epson Corporation
    Inventors: Tomoyuki Furuhata, Hideyuki Akanuma, Hiroaki Nitta
  • Patent number: 7972917
    Abstract: A method for manufacturing a semiconductor device is disclosed. The method includes: forming a LDMOS region, an offset drain MOS region, and a CMOS region; simultaneously forming a first well in the LDMOS region and the offset drain MOS region; simultaneously forming a second well in the first well of the LDMOS region and the CMOS region; and forming a second well in the CMOS region, wherein a depth of the first well is larger than a depth of the second well and the second well is a retrograde well formed by a high energy ion implantation method.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: July 5, 2011
    Assignee: Seiko Epson Corporation
    Inventors: Tomoyuki Furuhata, Hideyuki Akanuma, Hiroaki Nitta
  • Publication number: 20110136130
    Abstract: The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
    Type: Application
    Filed: August 21, 2009
    Publication date: June 9, 2011
    Inventors: Richard Gniewek, Michael Farrell, Hiroaki Nitta, Megan Lehrkamp, Jerome Kosmeder, Brian Daniel Kelly, Fabien Gaire, Mary Padilla, Thomas Grogan, Christopher Bieniarz
  • Patent number: 7851145
    Abstract: The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na+, K+-ATPase expression. For example, it is demonstrated herein that expression of the Na+, K+-ATPase ?1-subunit increases in cervical dysplasia and cervical cancer, relative to normal cervical tissue. Also provided are methods of treating cervical dysplasia and cervical cancer by decreasing the biological activity of the Na+, K+-ATPase. For example, therapeutically effective amounts of one or more Na+, K+-ATPase inhibitors can be applied to the cervix to treat cervical dysplasia and cervical cancer.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: December 14, 2010
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Hiroaki Nitta, Thomas M. Grogan, Phillip Miller
  • Publication number: 20100001345
    Abstract: A semiconductor device includes: a semiconductor substrate having a first conductivity type; a well having a second conductivity type and provided inside the semiconductor substrate; a first impurity region having the first conductivity type and provided within the well; a second impurity region having the second conductivity type, provided inside the well and away from the first impurity region; and a third impurity region having a first conductivity type, provided surrounding the well and away from the second impurity region. In this semiconductor device, the well is formed to be deeper than the first impurity region, the second impurity region, and the third impurity region, in a thickness direction of the semiconductor substrate; and a minimum distance between the first impurity region and the second impurity region is smaller than a minimum distance between the second impurity region and the third impurity region.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 7, 2010
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Tomoyuki Furuhata, Hideyuki Akanuma, Hiroaki Nitta
  • Publication number: 20100001342
    Abstract: A method for manufacturing a semiconductor device is disclosed. The method includes: forming a LDMOS region, an offset drain MOS region, and a CMOS region; simultaneously forming a first well in the LDMOS region and the offset drain MOS region; simultaneously forming a second well in the first well of the LDMOS region and the CMOS region; and forming a second well in the CMOS region, wherein a depth of the first well is larger than a depth of the second well and the second well is a retrograde well formed by a high energy ion implantation method.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 7, 2010
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Tomoyuki Furuhata, Hideyuki Akanuma, Hiroaki Nitta
  • Publication number: 20080299555
    Abstract: The present invention provides compositions, kits, assembles of articles and methodology for detecting multiple target molecules in a sample, such as in a tissue sample. In particular, site-specific deposition of elemental metal is used in conjunction with other means of detection, such as other chromogenic, radioactive, chemiluminescent and fluorescent labeling, to simultaneously detect multiple targets, such a gene, a protein, and a chromosome, in a biological sample. More particularly the multiple targets may be labeled with the specifically deposited metal and other chromogenic labels to allow chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 4, 2008
    Inventors: Hiroaki Nitta, Thomas M. Grogan
  • Publication number: 20080286386
    Abstract: The present disclosure provides methods of diagnosing cervical dysplasia and cervical cancer by detecting Na+, K+-ATPase expression. For example, it is demonstrated herein that expression of the Na+, K+-ATPase ?1-subunit increases in cervical dysplasia and cervical cancer, relative to normal cervical tissue. Also provided are methods of treating cervical dysplasia and cervical cancer by decreasing the biological activity of the Na+, K+-ATPase. For example, therapeutically effective amounts of one or more Na+, K+-ATPase inhibitors can be applied to the cervix to treat cervical dysplasia and cervical cancer.
    Type: Application
    Filed: December 27, 2006
    Publication date: November 20, 2008
    Inventors: Hiroaki Nitta, Thomas M. Grogan, Phillip Miller
  • Publication number: 20070193279
    Abstract: An air conditioned seat device has a support member, an air blower, a skin configured to form a seating surface, an air layer member, and an air-impermeable sheet member. The support member is provided with a duct for air. The air blower takes in air from the outside and passes the air through the duct. The skin passes air sent from the air blower. The air layer member, provided between the support member and skin, temporarily stores air supplied from the duct to form an air layer. The sheet member covering the air layer member is provided with an air flow-out opening configured to induce air to flow out from the air layer.
    Type: Application
    Filed: March 9, 2005
    Publication date: August 23, 2007
    Inventors: Noriyuki Yoneno, Fumitaka Kikutani, Hiroaki Nitta, Shintarou Nozawa, Takehiko Shigeoka, Akira Shiratake, Naohito Asami, Koichi Nakano, Satoshi Arima
  • Patent number: 6933117
    Abstract: The invention provides novel reagents, reagent kits, and methods for automated hybridization. More particularly, the invention provides reagents, reagent kits, and methods for automated in situ hybridization and automated hybridization on a microarray. The use of automated instruments for in situ hybridization and microarray hybridization dramatically reduces the amount of labor and time involved and also facilitates standardization of protocols and consistency between results.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: August 23, 2005
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Catherine Wolf, Hiroaki Nitta, Thomas Grogan, Jacques Cavadenti, Lidija Pestic-Dragovich, Anthony Hartman, Angela Sattler, Jennifer Wong
  • Publication number: 20030044823
    Abstract: The invention provides novel reagents, reagent kits, and methods for automated hybridization. More particularly, the invention provides reagents, reagent kits, and methods for automated in situ hybridization and automated hybridization on a microarray. The use of automated instruments for in situ hybridization and microarray hybridization dramatically reduces the amount of labor and time involved and also facilitates standardization of protocols and consistency between results.
    Type: Application
    Filed: April 30, 2002
    Publication date: March 6, 2003
    Inventors: Catherine Wolf, Hiroaki Nitta, Thomas Grogan, Jacques Cavadenti, Lidija Pestic-Dragovich, Anthony Hartman, Angela Sattler, Jennifer Wong