Abstract: The present invention provides an antihypertensive agent having a superior antihypertensive action, and a method for lowering blood pressure in mammals by inhalation of such an antihypertensive agent through the nostril. The antihypertensive agent of the present invention comprises citral and linalool, and has a mass ratio of citral to linalool of not less than 10:1 and not greater than 40:1. Since this antihypertensive agent has a superior antihypertensive action, it can be utilized as antihypertensive compositions for medical drugs, foods and beverages and feeds.

Abstract: An electrostatic spraying device for use in a chemical substance concentrating method, where the device includes a vessel, an injection port, a cooling part, an atomizing electrode section, and a unit for recovery of the chemical substance in the counter electrode section. Furthermore, the chemical substance concentration method includes the steps of: injecting a sample gas; producing a first condensate liquid from the sample gas; producing first charged fine particles from the first condensate liquid; producing second charged fine particles by mixing the first charged fine particles with the sample gas; and recovering the first charged fine particles and the second charged fine particles. According to a series of the operation described above, the chemical substances in the sample gas can be concentrated in a simple and efficient manner.

Abstract: A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.

Abstract: A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottomsurface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment.

Abstract: Provided are skin incision instrument to efficiently incise minimal portions and a method for incising skin with the skin incision instrument.

Abstract: An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode.

Abstract: The present invention of collecting gaseous sample employs the sealable container, the inlet mounted at a part of the container, the outlet mounted at the other part of the container, the atomizing electrode mounted in the container, the primary refrigerator mounted at adjacent to the atomizing electrode, the opposite electrode mounted in the container, the acicular capture electrode mounted at adjacent to the opposite electrode, and the secondary refrigerator mounted at adjacent to the capture electrode. Charged microparticles are prepared by chilling gaseous sample and producing condensate of the same. Such charged microparticles are collected by the capture electrode with static electricity, and they are condensed by chilling them. This method prevents the capture electrode from spreading solution thereon.

Abstract: Provided are skin incision instrument to efficiently incise minimal portions and a method for incising skin with the skin incision instrument.

Abstract: To provide an electrode plate for electrochemical measurements that enables detecting and quantifying the concentration of a target substance contained in a sample solution with rapidity and favorable sensitivity using an apparatus for electrochemical measurements is objected to.

Abstract: An instrument is provided for pharmacologic measurement capable of detecting a very small and short time change in electric signal caused by a pharmacologic action of a biologic specimen with quickness and a high sensitivity by steeply decreasing an external disturbance component mixed into the system while dropping/exchange of medicinal solutions is conducted in a batch mode.

Abstract: An electrode plate for electrochemical measurements capable of measuring the concentration of a target substance included in a sample solution with favorable accuracy and high sensitivity is provided. The electrode plate for electrochemical measurements of the present invention includes a substrate, an upper layer, a lower layer, a first electrode body sandwiched between the substrate and the upper layer, and a second electrode body sandwiched between the substrate and the lower layer, wherein: the upper layer has a plurality of upper layer through-holes; the first electrode body has a plurality of first electrodes exposed from via the upper layer through-hole in the first electrode body; the substrate has a plurality of substrate through-holes; and the second electrode body has a plurality of second electrodes exposed via the upper layer through-hole and the substrate through-hole in the second electrode body.

Abstract: A sensor of pyrophosphate which can detect pyrophosphate conveniently with high sensitivity in a method for measuring pyrophosphate in SNP typing utilizing a primer extension reaction is provided. A sensor of pyrophosphate which is characterized by including: an insulative substrate 1; an electrode system that is formed thereon and has a measurement electrode 2 and a counter electrode 3; and a plurality of reaction reagent layers that are provided on the substrate 1 and include pyrophosphatase, glyceraldehyde-3-phosphate dehydrogenase, diaphorase, glyceraldehyde-3-phosphate, oxidized nicotineamide adenine dinucleotide, an electronic mediator, a magnesium salt and a buffer component, reaction reagent layer 36 including the enzyme being separated from reaction reagent layer 35 including the buffer component, and reaction reagent layer 37 including glyceraldehyde-3-phosphate being separated from the reaction reagent layer 35 including the buffer component.

Abstract: Handling of the condensate collecting vessel in conventional breath analysis apparatuses having a cold condensation mechanism is complicated, and time consuming.

Abstract: The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.

Abstract: A method for removing slag comprises: preparing a filter 21 of heat-resistant porous ceramics, which passes a molten metal and catches slag, liquidizing metal material to form a molten metal A on which slag is floating; and traveling filter 21 along a surface of the molten metal A and removing slag. And a device for removing slag comprises: a filter 21 of heat-resistant porous ceramics, which passes a molten metal and catches slag; and a driving device for traveling filter 21 along a surface of the molten metal on which slag is floating and removing slag.

Abstract: A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape.

Abstract: An electrode plate for electrochemical measurements capable of measuring the concentration of a target substance included in a sample solution with favorable accuracy and high sensitivity is provided The electrode plate for electrochemical measurements 1 of the present invention includes a substrate 31, an upper layer 40 provided on the superior face of the substrate, a lower layer 11 provided on the inferior face of the substrate, a first electrode body 32 sandwiched between the superior face of the substrate and the upper layer, and a second electrode body 12 sandwiched between the inferior face of the substrate and the lower layer, wherein: the upper layer has a plurality of upper layer through-holes 41; the first electrode body has a plurality of first electrodes 32d including a portion exposed from the superior face of the upper layer via the upper layer through-hole in the first electrode body; the substrate has a plurality of substrate through-holes 33; and the second electrode body has a plurality of

Abstract: A fluid chip has a liquid support 25 for supporting a liquid 24, a fluid passage 22 formed by being surrounded by the liquid support 25 and through which the liquid 24 moves, and a plurality of magnetic particles 21 disposed in the fluid passage 24. The magnetic particles 21 are aggregated by a permanent magnet 23 so as to block the fluid passage 22 and thus cut off flow of the liquid 24. The magnetic particles 21 are dispersed along a part of a wall of the fluid passage 22 so as to open the fluid passage 22 and thus allow the liquid 24 to flow.

Abstract: A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily.

Abstract: A liquid delivery apparatus 1 has a rotary substrate 2. The substrate 2 formed with a fluid passage 8A for communicating a supply chamber 6A and target chamber 7A. An inlet end portion 13 at which the fluid passage 8A is connected to the chamber 6A extends in a clockwise direction R1 of rotational directions of the substrate 2. The inlet end portion 13 holds a liquid 9 in the chamber 6A by a capillary force. The rotation drive unit 4 rotates the substrate 2 so that an inertial force exceeding the capillary force and directed to the clockwise direction R1 acts on the liquid 9 in the inlet end portion 13. Delivery behavior control of microfluid with a high degree of flexibility can be achieved.