Patents by Inventor Hiroaki Tokiwa

Hiroaki Tokiwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9738675
    Abstract: A diarylethene compound represented by formula (I) wherein, Sg is a monovalent sugar residue formed by removing one hydroxyl group from a sugar compound or a monovalent protected sugar residue formed by removing one hydroxyl group from a sugar compound in which one or more other hydroxyl groups are protected, and wherein the sugar is selected from the group consisting of a six-membered ring sugar, a five-membered ring sugar, cyclitol, and oligosaccharides containing a six-membered ring sugar, a five-membered ring sugar, or cyclitol; U is —(CH2)n—, —CH2—U?—, or —C(?O)— wherein n is an integer of 1 to 5, U? is a C2-C10 branched alkylene group binding to Ar); and Ar is a group represented by formula (A1) or (A2); wherein, X is S, SO2, NR3 in which R3 is a C1-C3 alkyl group, or O, R is C1-C4 alkyl group, R1 and R2 are independently a C1-C3 alkyl group, a is 0 or 1, b is an integer of 0-3, and * represents a bond with U; Y is a hydrogen atom or a halogen atom; and m is an integer of 3 to 5.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 22, 2017
    Assignees: RIKKYO EDUCATIONAL CORPORATION, JOSHO GAKUEN EDUCATIONAL FOUNDATION
    Inventors: Hiroaki Tokiwa, Masahiro Irie, Kiyoshi Ikeda, Tadamune Otsubo
  • Publication number: 20150307541
    Abstract: A diarylethene compound having high water-solubility is provided, and the compound is a diarylethene compound of formula (I) wherein, Sg is a monovalent sugar-type residue consisting of a sugar-type compound (in which some of hydroxyl groups may be protected) selected from a group consisting of a six-membered ring sugar, a five-membered ring sugar, cyclitol and oligosaccharides containing a six-membered ring sugar, a five-membered ring sugar, or cyclitol and excluding an hydroxyl group; U is —(CH2)n-, —CH2—U?—, or —C(?O)— (wherein, n is an integer of 1 to 5, U? is a C1-C10 alkyl group binding to Ar); and Ar is a group represented by formula (A1) or (A2); wherein, X is S, SO2, NR3 (R3 is a C1-C3 alkyl group) or O, R is C1-C4 alkyl group, R1 and R2 are independently a C1-C3 alkyl group, a is 0 or 1, b is an integer of 0-3, and * represents a bond with U); Y is a hydrogen atom or a halogen atom; m is an integer of 5-7.
    Type: Application
    Filed: September 6, 2013
    Publication date: October 29, 2015
    Applicant: RIKKYO EDUCATIONAL CORPORATION
    Inventors: Hiroaki TOKIWA, Masahiro IRIE, Kiyoshi IKEDA, Tadamune OTSUBO
  • Patent number: 9018194
    Abstract: The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0; R represents a hydrogen atom or an alkyl group; Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; and Z1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, or Z1 and Z2 jointly form a methylene group.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: April 28, 2015
    Assignees: Nibon University
    Inventors: Makoto Makishima, Sachiko Yamada, Antonio Mourino, Hiroaki Tokiwa, Takeru Kudo, Yusuke Watarai, Kazuki Maekawa
  • Publication number: 20140038925
    Abstract: The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0; R represents a hydrogen atom or an alkyl group; Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; and Z1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, or Z1 and Z2 jointly form a methylene group.
    Type: Application
    Filed: March 1, 2012
    Publication date: February 6, 2014
    Inventors: Makoto Makishima, Sachiko Yamada, Antonio Mourino, Hiroaki Tokiwa, Takeru Kudo, Yusuke Watarai, Kazuki Maekawa