Patents by Inventor Hirofumi Mukai
Hirofumi Mukai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11214838Abstract: The present invention provides a factor capable of predicting an effect of a medicinal therapy on a cancer such as HER2 positive cancer. More specifically, the present invention provides a method of predicting the effect of the medicinal therapy on the cancer, comprising: (1) analyzing a methylation level of a cytosine residue in one or more CpG sites present within a nucleotide sequence in a promotor region, an untranslated region or a translated region of HSD17B4 gene in a sample taken from a human subject; and (2) predicting the effect of the medicinal therapy on the cancer based on the analyzed methylation level.Type: GrantFiled: March 15, 2017Date of Patent: January 4, 2022Assignees: NATIONAL CANCER CENTER, H.U. Group Research Institute G.K.Inventors: Hirofumi Mukai, Toshikazu Ushijima, Satoshi Yamashita
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Publication number: 20190169701Abstract: The present invention provides a factor capable of predicting an effect of a medicinal therapy on a cancer such as HER2 positive cancer. More specifically, the present invention provides a method of predicting the effect of the medicinal therapy on the cancer, comprising: (1) analyzing a methylation level of a cytosine residue in one or more CpG sites present within a nucleotide sequence in a promotor region, an untranslated region or a translated region of HSD17B4 gene in a sample taken from a human subject; and (2) predicting the effect of the medicinal therapy on the cancer based on the analyzed methylation level.Type: ApplicationFiled: March 15, 2017Publication date: June 6, 2019Applicants: NATIONAL CANCER CENTER, Miraca Research Institute G.K.Inventors: Hirofumi MUKAI, Toshikazu USHIJIMA, Satoshi YAMASHITA
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Patent number: 7965563Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: February 2, 2009Date of Patent: June 21, 2011Assignees: Renesas Technology Corp., Hitachi ULSI Systems Co., Ltd.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20090157953Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: February 2, 2009Publication date: June 18, 2009Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 7505329Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: September 25, 2007Date of Patent: March 17, 2009Assignees: Renesas Technology Corp., Hitachi ULSI Systems, Co., Ltd.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20080028134Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: September 25, 2007Publication date: January 31, 2008Inventors: Kiyoshi MATSUBARA, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 7295476Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: January 25, 2007Date of Patent: November 13, 2007Assignees: Renesas Technology Corp., Hitachi ULSI Systems Co., Ltd.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20070133308Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: January 25, 2007Publication date: June 14, 2007Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 7184321Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: October 7, 2005Date of Patent: February 27, 2007Assignees: Hitachi Ulsi Systems Co., Ltd., Renesas Technology Corp.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 7093042Abstract: A process program such as an erasing/programming program is stored in a boot mat in a nonvolatile memory operational in a boot mode specified after reset start, and a transfer control program for the process program is also stored therein in advance. With an action of setting control information to a predetermined register as trigger, the state of an on-chip CPU is changed from placed in execution of an optional user program to enabled for execution of a transfer control program in the boot mat, and the CPU is returned to the re-execution state of the optional program, after the process program is transferred to an on-chip RAM.Type: GrantFiled: February 22, 2002Date of Patent: August 15, 2006Assignees: Renesas Technology Corp., Hitachi Hokkai Semiconductor, Ltd.Inventors: Toshihiro Matsuo, Hiromichi Ishikura, Hirofumi Mukai, Naoki Yada
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Patent number: 7057937Abstract: A data processing apparatus having a built-in flash memory and being capable of rewriting the built-in flash memory by use of versatilely used PROM writer has a CPU, an electrically rewritable nonvolatile flash memory both formed in a single semiconductor substrate, and is operable in a mode in which the built-in flash memory is rewritable in accordance with commands supplied from a PROM writer. The data processing apparatus has a command latch made externally writable when the above-mentioned operation mode is established, a command analyzer and a sequence controller for controlling a sequence of rewriting the flash memory in accordance with the analysis result. The command analyzer and sequence controller may be realized by the CPU.Type: GrantFiled: August 10, 1998Date of Patent: June 6, 2006Assignees: Renesas Technology Corp., Hitachi ULSI Systems Co., Ltd.Inventors: Kiyoshi Matsubara, Masanao Sato, Hirofumi Mukai, Eiichi Ishikawa
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Publication number: 20060034129Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: October 7, 2005Publication date: February 16, 2006Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 6999350Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: July 26, 2004Date of Patent: February 14, 2006Assignees: Renesas Technology Corp., Hitachi ULSI Systems Co., Ltd.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20040268025Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Method for manufacturing a printed board on which a semiconductor device having two modes is mounted
Patent number: 6804152Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: September 24, 2002Date of Patent: October 12, 2004Assignees: Renesas Technology Corp., Hitachi ULSI Systems Co., Ltd.Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba -
Patent number: 6690603Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: June 3, 2002Date of Patent: February 10, 2004Assignees: Hitachi, Ltd., Hitachi VLSI Engineering CorporationInventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20030021157Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: September 24, 2002Publication date: January 30, 2003Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: 6493271Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: GrantFiled: November 16, 2001Date of Patent: December 10, 2002Assignees: Hitachi, Ltd., ULSI Engineering CorporationInventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Publication number: 20020181289Abstract: A semiconductor device having an electrically erasable and programmable nonvolatile memory, for example, a rewritable nonvolatile memory including memory cells arranged in rows and columns and disposed to facilitate both flash erasure as well as selective erasure of individual units of plural memory cells. The semiconductor device which functions as a microcomputer chip also has a processing unit and includes an input terminal for receiving an operation mode signal for switching the microcomputer between a first operation mode in which the flash memory is rewritten under control of a processing unit and a second operation mode in which the flash memory is rewritten under control of separate writing circuit externally connectable to the microcomputer.Type: ApplicationFiled: June 3, 2002Publication date: December 5, 2002Inventors: Kiyoshi Matsubara, Naoki Yashiki, Shiro Baba, Takashi Ito, Hirofumi Mukai, Masanao Sato, Masaaki Terasawa, Kenichi Kuroda, Kazuyoshi Shiba
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Patent number: D815377Type: GrantFiled: January 12, 2017Date of Patent: April 10, 2018Assignee: MARUYAMA MFG. CO., INC.Inventor: Hirofumi Mukai