Abstract: The present invention is achieved based on a novel finding that chitosan gel having retentivity in tissue has an antitumor activity and provides an antitumor composition containing chitosan gel having retentivity in tissue. The chitosan gel having retentivity in tissue of the present invention is preferably chitosan gel formed of a chitosan derivative having a carbohydrate chain introduced thereto as a base, to which a photoreactive group is further introduced to form crosslink with photo-irradiation; or chitosan gel formed of a polyion complex, which is formed of a carbohydrate chain-containing chitosan derivative and another substance, for example, an acidic polysaccharide. The antitumor composition of the present invention can suppress growth of a tumor without bringing it into contact with the tumor but by simply arranging it near the tumor.

Abstract: The present invention provides a medical composition which, in autotransplantation which is the only method that can induce the epithelialization even in a widespread full-thickness skin defect, enables the fixation of an autotransplantation skin graft in a simple manner and can increase the efficiency of epithelialization to promote the regeneration of the skin. The present invention elates to a medical composition comprising a photo-crosslinkable chitosan derivative and an amino acid and/or a saccharide. The amino acid is preferably an essential amino acid, and the saccharide is preferably a neutral saccharide selected from glucose, galactose, mannose and fucose.

Abstract: The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

Abstract: The present invention is intended to offer a novel material which combines cell-adhesive proteins such as collagen with GAG polymers to construct an environment similar to an extracellular matrix, capable of controlling differentiation and proliferation of cells. The present invention offers a glycosaminoglycan-functionalized polymer protein composite produced by combining a cell-adhesive protein with a glycosaminoglycan-functionalized polymer obtained by incorporating a carbohydrate chain containing a structure corresponding to at least a portion of a glycosaminoglycan backbone into a vinyl polymer main chain, as well as a cell culture substrate and a material for tissue reconstruction treatments comprising the composite.

Abstract: The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

Abstract: A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosaminoglycan and which, due to the incorporation, has solubility in a neutral medium, self-crosslinking ability, the property of highly containing water or healing wounds, and antithrombotic properties. Namely, the derivative has various properties required of health care materials such as medical products and cosmetics.

Abstract: The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner from glycosaminoglycan controlling adhesion, migration and proliferation of cells via linkage to various cellular growth factors or cytokines or direct interactions with the cells. The functionalized polymer of the present invention is characterized in that it comprises a carbohydrate corresponding to at least a part of the basic structure of glycosaminoglycan introduced into a vinyl-type polymer chain.

Abstract: A medical composition is provided which is advantageous as a sealant for wound openings as well as have a function promoting healing of intractable wound or incision wound, and which accelerate tissue regeneration but does not cause any side effect such as canceration. The present invention relates to a medical composition comprising a photo-crosslinkable chitosan derivative and a wound healing promoter. The photo-crosslinkable chitosan derivative is preferably a polymer obtainable by incorporating a carbohydrate chain containing a reducing terminal to at least one portion of amino groups of chitosan back bone and incorporating a photoreactive group to at least another part of the amino groups. The wound healing promoter is preferably a growth factor.

Abstract: A blood cell separating system is offered for precisely separating and concentrating rare fetal nucleated cells intermixed in the blood of a pregnant woman, to conveniently obtain test preparations capable of being used for prenatal chromosomal/genetic diagnosis. A blood cell separating system is characterized by comprising (1) a primary separating device for removing mainly non-nucleated erythrocytes, leukocytes and platelets from blood samples taken from a pregnant woman to obtain a primary separated sample, (2) a secondary separating device for using a carbohydrate-lectin method to remove residual non-nucleated erythrocytes and leukocytes from the primary separated sample obtained by the primary separating device to obtain a secondary separated sample with concentrated fetal nucleated cells, and (3) preparing device for preparing the secondary separated sample obtained by the secondary separating device.

Abstract: The present invention provides a method for selective and high-yield separation, concentration, and recovery of desired cells from a blood sample.

Abstract: The present invention provides a method for selective and high-yield separation, concentration, and recovery of desired cells from a blood sample.

Abstract: A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosaminoglycan and which, due to the incorporation, has solubility in a neutral medium, self-crosslinking ability, the property of highly containing water or healing wounds, and antithrombotic properties. Namely, the derivative has various properties required of health care materials such as medical products and cosmetics.

Abstract: The present invention is intended to offer a novel material which combines cell-adhesive proteins such as collagen with GAG polymers to construct an environment similar to an extracellular matrix, capable of controlling differentiation and proliferation of cells. The present invention offers a glycosaminoglycan-functionalized polymer protein composite produced by combining a cell-adhesive protein with a glycosaminoglycan-functionalized polymer obtained by incorporating a carbohydrate chain containing a structure corresponding to at least a portion of a glycosaminoglycan backbone into a vinyl polymer main chain, as well as a cell culture substrate and a material for tissue reconstruction treatments comprising the composite.