Patents by Inventor Hiroki Ishihara

Hiroki Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050150247
    Abstract: An outdoor air conditioner unit is connected to indoor units by a gaseous refrigerant communication pipe and a liquid refrigerant communication pipe. The outdoor air conditioner unit is provided with a gas-side shut-off valve and a liquid-side shut-off valve. The gas-side shut-off valve has a pipe connecting port to which the gaseous refrigerant communication pipe is connected. The liquid-side shut-off valve has a pipe connecting port to which the liquid refrigerant communication pipe is connected. In a plan view, the pipe connecting ports are offset from each other in both the depthwise direction and the widthwise direction. Thus, the outdoor air conditioner unit is configured to reduce interference between the refrigerant pipes connected to the gas-side and liquid-side shut-off valves of the outdoor unit.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 14, 2005
    Applicant: Daikin Industries,Ltd.
    Inventors: Hiroki Ishihara, Hiromune Matsuoka, Toshiaki Mukaidani, Tadashi Sao
  • Publication number: 20050144975
    Abstract: The present invention reduces the size of an outdoor refrigerator unit of the type that draws in air from a lateral face, exchanges heat with the air, and blows the air out of a top face while ensuring that the electrical equipment box has sufficient volume and suppressing the increase in the air flow resistance. The air conditioning system outdoor unit is of the type that draws in air from air inlets provided in the rear panel and a pair of side panels of a casing exchanges heat with the air, and blows the air out through an air outlet provided in a top panel. The outdoor unit is provided with an axial fan and an electrical equipment box arranged inside the casing. The electrical equipment box is arranged inside the casing and has a first box part that is provided below the axial fan and a second box part that is provided below the first box part and has a larger surface area in a plan view than the first box part.
    Type: Application
    Filed: October 27, 2003
    Publication date: July 7, 2005
    Inventors: Hiroshi Fuchikami, Hiroki Ishihara, Tadashi Sao, Toshiaki Mukaidani
  • Publication number: 20050000239
    Abstract: The present invention includes foundation legs of an outdoor unit that are made of a relatively thin plate material, and can reduce costs. This outdoor unit includes a compressor, an outdoor refrigerant circuit that includes pipes and a heat exchanger, a case that houses the refrigerant circuit, and a plurality of supports provided so that they protrude downward from the bottom part of the case. Furthermore, foundation legs are provided at the lower ends of the plurality of supports for fixing such, so that they extend towards the inner side of the case.
    Type: Application
    Filed: June 27, 2003
    Publication date: January 6, 2005
    Inventors: Hiroki Ishihara, Hiromune Matsuoka, Toshiaki Mukaidani, Tadashi Sao
  • Patent number: 6784192
    Abstract: The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: August 31, 2004
    Assignee: Eisai Co., Ltd.
    Inventors: Fumihiro Ozaki, Toshihiko Kaneko, Mutsuko Tabata, Yoshinori Takahashi, Kazuki Miyazaki, Junichi Kamata, Ichiro Yoshida, Masayuki Matsukura, Hiroyuki Suzuki, Takashi Yoshinaga, Hiroki Ishihara, Hiroshi Katoh, Kohei Sawada, Tatsuhiro Onogi, Kiyoaki Kobayashi, Miyuki Ohkubo
  • Patent number: 6699870
    Abstract: The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: March 2, 2004
    Assignee: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Norio Karibe, Kazuki Miyazaki, Fumihiro Ozaki, Atsushi Kamada, Shuhei Miyazawa, Yoshimitsu Naoe, Toshihiko Kaneko, Itaru Tsukada, Tadashi Nagakura, Hiroki Ishihara, Kohtarou Kodama, Hideyuki Adachi
  • Publication number: 20030220368
    Abstract: The present invention provides a novel compound having a superior Na+ channel inhibition activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them.
    Type: Application
    Filed: July 19, 2002
    Publication date: November 27, 2003
    Inventors: Fumihiro Ozaki, Toshihiko Kaneko, Mutsuko Tabata, Yoshinori Takahashi, Kazuki Miyazaki, Junichi Kamata, Ichiro Yoshida, Masayuki Matsukura, Hiroyuki Suzuki, Takashi Yoshinaga, Hiroki Ishihara, Hiroshi Katoh, Kohei Sawada, Tatsuhiro Onogi, Kiyoaki Kobayashi, Miyuki Ohkubo
  • Publication number: 20030105074
    Abstract: The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: 1
    Type: Application
    Filed: October 28, 2002
    Publication date: June 5, 2003
    Applicant: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Norio Karibe, Kazuki Miyazaki, Fumihiro Ozaki, Atsushi Kamada, Shuhei Miyazawa, Yoshimitsu Naoe, Toshihiko Kaneko, Itaru Tsukada, Tadashi Nagakura, Hiroki Ishihara, Kohtarou Kodama, Hideyuki Adachi
  • Patent number: 6503060
    Abstract: A frame (4a) is provided around the perimeter of the air outlet (2a) of the fan (6). The frame (4a) includes a plurality of board-shaped ribs (41, 41 . . . ) extending radially outward from the vicinity of the center of the frame (4a) in the direction of the radius of the fan (6). The frame (4a) also includes a plurality of cylindrical ribs (42, 42 . . . ) integrated with the plurality of board-shaped ribs (41, 41 . . . ), and arranged concentrically around the rotation axis (O-O′) of the fan (6) at predetermined intervals in the direction of the radius of the fan (6). The board-shaped ribs (41) are curved outward in the direction of rotation of the fan (6) and inclined in the direction of air flowing from the fan (6).
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: January 7, 2003
    Assignee: Daikin Industries, Ltd.
    Inventors: Masashi Kamada, Tadashi Ohnishi, Manabu Kato, Hiroki Ishihara, Tatsuo Fujiwara, Masaki Yamamoto
  • Patent number: 6498159
    Abstract: The present invention provides a phthalazine compound as a therapeutic agent for erectile dysfunction represented by the following formula, a pharmacologically acceptable salt thereof or a hydrate thereof: wherein R1 and R2 are the same as or different from each other and represent a halogen atom, a C1 to C4 alkyl group which may be substituted with a halogen atom, a C1 to C4 alkoxy group which may be substituted with a halogen atom or a cyano group; X represents a cyano group, a nitro group, a halogen atom, a hydroxyimino group which may be substituted or a heteroaryl group which may be substituted; Y represents a heteroaryl group, an aryl group which may be substituted, an alkynyl group which may substituted, an alkenyl group, an alkyl group, an optionally substituted saturated or unsaturated 4- to 8-membered amine ring, and the cyclic amine compound is a monocyclic compound, bicyclic compound or a spiro compound; l is an integer of 1 to 3; provided that the case where l is 1 or 2, X is a
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: December 24, 2002
    Assignee: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Norio Karibe, Kazuki Miyazaki, Fumihiro Ozaki, Atsushi Kamada, Shuhei Miyazawa, Yoshimitsu Naoe, Toshihiko Kaneko, Itaru Tsukada, Tadashi Nagakura, Hiroki Ishihara, Kohtarou Kodama, Hideyuki Adachi
  • Patent number: 6288064
    Abstract: The present invnetion provides a remedy for erectile dysfunction. The active ingredient thereof is a fused pyridazine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: (wherein the ring C represents a 5 or 6 membered ring optionally having hetero atom(s); n is an integer of from 1 to 4; R1 represents a hydrogen, a halogen, a cyano, etc.; A represents a hydrogen, a halogen, an optionally substituted amino, etc.; X represents a group represented by the formula —N═, etc.; and Y represents the formula —CO—, an optionally substituted amino, etc).
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: September 11, 2001
    Assignee: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Yasuhiro Kabasawa, Shinya Abe, Mayu Shibazaki, Hiroki Ishihara, Kohtarou Kodama, Hideyuki Adachi
  • Patent number: 6218392
    Abstract: A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as “cGMP-PDE”). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: April 17, 2001
    Assignee: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Yasuhiro Kabasawa, Yasutaka Takase, Fumihiro Ozaki, Keiji Ishibashi, Kazuki Miyazaki, Masayuki Matsukura, Shigeru Souda, Kazutoshi Miyake, Hiroki Ishihara, Kohtaro Kodama, Hideyuki Adachi
  • Patent number: 5935324
    Abstract: An apparatus for forming I-III-VI.sub.2 thin-film layers has a reaction chamber made of a carbon material in which a precursor for forming a I-III-VI.sub.2 thin-film layer and a vapor source of an element of group VI of the periodic table are placed. The precursor and vapor source are heated under vacuum to form the I-III-VI.sub.2 thin-film layer. The reaction chamber is divided into a reaction compartment A having the precursor placed therein and a reaction compartment B having the vapor element of group IV placed therein. A communication channel C is provided between the reaction compartments A and B, and a heating unit controlled by a temperature control unit is provided exterior to each of the reaction compartments A and B.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: August 10, 1999
    Assignee: Yazaki Corporation
    Inventors: Shinnichi Nakagawa, Kenji Sato, Masami Nakamura, Kazuhiro Toyoda, Takeshi Kamiya, Kazue Suzuki, Hiroki Ishihara, Takeshi Ikeya, Masaharu Ishida
  • Patent number: 5910336
    Abstract: An improved process for producing a light-absorbing chalcopyrite film is disclosed, which comprises the steps of: applying at least one solution containing at least either of (a) an organic compound of a metal in Group 1B of the periodic table and (b) an organic compound of a metal in Group 3B of the periodic table on a substrate at least once to thereby form a thin film containing the organic compound (a) and the organic compound (b); heating the thin film in a reducing or inert gas atmosphere to convert the thin film into a thin metal film comprising the Group 1B metal and the Group 3B metal; and heating the thin metal film in an atmosphere containing either an element in Group 6B of the periodic table or a compound thereof to thereby convert the thin metal film into a thin chalcopyrite film.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: June 8, 1999
    Assignee: Yazaki Corporation
    Inventors: Hiroki Ishihara, Shinichi Nakagawa, Norio Mochizuki, Masaharu Ishida
  • Patent number: 5849741
    Abstract: A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE").The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: December 15, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: Nobuhisa Watanabe, Yasuhiro Kabasawa, Yasutaka Takase, Fumihiro Ozaki, Keiji Ishibashi, Kazuki Miyazaki, Masayuki Matsukura, Shigeru Souda, Kazutoshi Miyake, Hiroki Ishihara, Kohtaro Kodama, Hideyuki Adachi
  • Patent number: 5716993
    Abstract: The present invention provides an anthranilic acid derivative having a cGMP-PDE inhibitory activity.An anthranilic acid derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## ?wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent the same or different from each other, a hydrogen atom, a halogen atom, a hydroxy group, an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, a nitro group, a hydroxyalkyl group, a cyano group or the like; R.sup.5 and R.sup.6 represent the same or different from each other, a hydrogen atom, a halogen atom, a hydroxy group, a cyano group, an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group or the like;W represents a group of the formula: --N.dbd. or --CH.dbd.; R.sup.7 and R.sup.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: February 10, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: Fumihiro Ozaki, Keiji Ishibashi, Hironori Ikuta, Hiroki Ishihara, Shigeru Souda
  • Patent number: 5707998
    Abstract: The present invention relates to a nitrogen-containing heterocyclic compound exhibiting an inhibitory activity against cGMP-PDE. The compound represented by the formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represent hydrogen, lower alkyl or the like) or the like; R.sup.2 represents a group represented by the formula: ##STR2## (wherein R.sup.8 represents a carboxyl group which may be protected, or the like) or the like; and R.sup.3 represents a group represented by the formula: ##STR3## (wherein R.sup.6 and R.sup.7 each represent hydrogen, lower alkyl or the like) or the like.
    Type: Grant
    Filed: September 25, 1995
    Date of Patent: January 13, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: Yasutaka Takase, Nobuhisa Watanabe, Hideyuki Adachi, Kohtaro Kodama, Hiroki Ishihara, Takao Saeki, Shigeru Souda
  • Patent number: 5614627
    Abstract: It relates to a quinazoline compound useful as a medicine exhibiting an inhibitory action on calmodulin-dependent cGMP-PDE.A quinazoline compound represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different from each other and each represents a hydrogen atom, a lower alkyl group or the like; and R.sup.6 and R.sup.7 may be the same or different from each other and each represents a hydrogen atom, a carboxyl alkyl group or the like).
    Type: Grant
    Filed: June 27, 1995
    Date of Patent: March 25, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Yasutaka Takase, Nobuhisa Watanabe, Hideyuki Adachi, Kohtaro Kodama, Hiroki Ishihara, Takao Saeki, Shigeru Souda
  • Patent number: 5506238
    Abstract: The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: April 9, 1996
    Assignee: Eisai Co., Ltd.
    Inventors: Kazutoshi Miyake, Masayuki Matsukura, Naoki Yoneda, Osamu Hiroshima, Nobuyuki Mori, Hiroki Ishihara, Takashi Musha, Toshiyuki Matsuoka, Sachiyuki Hamano, Norio Minami
  • Patent number: 5444083
    Abstract: A pyrrolidine compound having the following formula and a pharmacologically acceptable salt thereof is disclosed. It is useful in the pharmaceutical field. ##STR1## in which X is hydrogen, a halogen, or a lower alkyl, Y is --(CH2)n--, n being zero, 1 or 2, --S(O)p--, p being zero, 1 or 2, --O--, or --NH-- and R is phenyl, a substituent-having phenyl, naphtyl, a substituent-having naphthyl, a heteroaryl or a substituent-having heteroaryl.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: August 22, 1995
    Assignee: Eisai Co., Ltd.
    Inventors: Motosuke Yamanaka, Tomonori Hoshiko, Shinji Suda, Naoki Yoneda, Nobuyuki Mori, Mitsumasa Shino, Hiroki Ishihara, Mamoru Saito, Toshiyuki Matsuoka
  • Patent number: 5328911
    Abstract: The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: July 12, 1994
    Assignee: Eisai Co., Ltd.
    Inventors: Kazutoshi Miyake, Masayuki Matsukura, Naoki Yoneda, Osamu Hiroshima, Nobuyuki Mori, Hiroki Ishihara, Takashi Musha, Toshiyuki Matsuoka, Sachiyuki Hamano, Norio Minami