Patents by Inventor Hiroki Yoshioka

Hiroki Yoshioka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11933520
    Abstract: A fluid-heating device for heating fluid with a heater includes: a heating portion that is molded so as to cover the surrounding of the heater; and a support body integrally cast into the heating portion, the heating portion being molded in a state in which the heater is supported by the support body in a die for molding the heating portion.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: March 19, 2024
    Assignee: MARELLI CABIN COMFORT JAPAN CORPORATION
    Inventors: Takeshi Ogasawara, Naohisa Kamiyama, Hiroki Yoshioka, Takashi Otsuka, Daiju Suzuki
  • Patent number: 11905367
    Abstract: A branched monodispersed polyethylene glycol represented by the formula (1): wherein X1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L1 represents a single bond, —NH—, -L2-(CH2)m1- or -L2-(CH2)m1-L3-(CH2)m2-, L2 represents an ether bond, an amide bond, an urethane bond or a single bond, L3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: February 20, 2024
    Assignee: NOF CORPORATION
    Inventors: Mika Hamura, Yuki Matsuno, Hiroki Yoshioka
  • Patent number: 11905366
    Abstract: A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: February 20, 2024
    Assignee: NOF CORPORATION
    Inventors: Akihide Onozawa, Hiroki Yoshioka, Masaki Kamiya
  • Publication number: 20220389629
    Abstract: To provide a flexible conductive base member and a multilayer conductive base member including the same, having no problem of failing to function as a contact and causing a variation in height between contacts. There are a covered region 10 covered with a noble metal and a non-covered region 20 not circumferentially covered with a noble metal on a surface of a reticulated fibrous body 50. The covered region 10 is located at an intersection 7 of fibers 5 of the reticulated fibrous body 50, and the intersections 7 are connected to each other. The non-covered region 20 is located between the intersections 7 of the fibers 5 of the reticulated fibrous body 50.
    Type: Application
    Filed: November 27, 2020
    Publication date: December 8, 2022
    Applicant: UNITED PRECISION TECHNOLOGIES CO., LTD.
    Inventors: SATOSHI OSAWA, HIDEKI SATO, SHUJI KUNIOKA, HIROKI YOSHIOKA
  • Publication number: 20220387609
    Abstract: A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.
    Type: Application
    Filed: March 26, 2020
    Publication date: December 8, 2022
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Kazuki OSAKAMA, Mika HAMURA, Takanori INABA, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Takahiro NOMOTO, Xiaohang SUN
  • Publication number: 20220380533
    Abstract: A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.
    Type: Application
    Filed: September 25, 2020
    Publication date: December 1, 2022
    Inventors: Hiroki Yoshioka, Ken Hamura, Kazuki Osakama, Nobuhiro Nishiyama
  • Publication number: 20220362397
    Abstract: A heterobifunctional monodisperse polyethylene glycol with two adjacent monodisperse polyethylene glycol side chains, in which a peptide linker is degraded by intracellular enzymes to release a drug slowly and effectively mask the hydrophobicity of the drug, and an antibody-drug conjugate in which the antibody and the drug are bound using same is provided. A heterobifunctional monodisperse polyethylene glycol represented by the formula (1): wherein each symbol in the formula (1) is as defined in the DESCRIPTION.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 17, 2022
    Applicant: NOF CORPORATION
    Inventors: Yuki MATSUNO, Hiroki YOSHIOKA, Akira SUZUKI
  • Publication number: 20220339290
    Abstract: A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein k1 and k2 are each independently 1-12, j1 and j2 are each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and L1 and L2 are each independently a single bond or a divalent spacer.
    Type: Application
    Filed: September 25, 2020
    Publication date: October 27, 2022
    Inventors: Ken Hamura, Hiroki Yoshioka, Kazuki Osakama, Nobuhiro Nishiyama
  • Patent number: 11411549
    Abstract: In a crystal resonator plate (2), a support part (24) extends from only one corner part positioned in the +X direction and in the ?Z? direction of a vibrating part (22) to an external frame part (23) in the ?Z? direction. The vibrating part (22) and at least part of the support part (24) form an etching region (Eg) having a thickness thinner than a thickness of the external frame part (23). A stepped part is formed at a boundary of the etching region (Eg), and a first lead-out wiring (223) is formed over the support part (24) to the external frame part (23) so as to overlap with the stepped part. At least part of the stepped part that is superimposed on the first lead-out wiring (223) is formed so as not to be parallel to the X axis in plan view.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: August 9, 2022
    Assignee: Daishinku Corporation
    Inventor: Hiroki Yoshioka
  • Publication number: 20220216847
    Abstract: Among a plurality of electrodes for mounting purpose, all of the electrodes for mounting purpose but two paired ones of the electrodes for mounting purpose that are connected to driving electrodes each have a wiring pattern for use in electrical connection between terminals for external connection and mounting terminals of IC. These wiring patterns each have a constricted portion smaller in width than the other portions that prevents the conduction of heat.
    Type: Application
    Filed: February 12, 2020
    Publication date: July 7, 2022
    Inventor: Hiroki YOSHIOKA
  • Publication number: 20220192981
    Abstract: The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Yb, Za, and Zb are as defined in the specification.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 23, 2022
    Applicants: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Yuta NAKAI, Kota TANGE, Hiroki YOSHIOKA, Shinya TAMAGAWA, Hidetaka AKITA, Hiroki TANAKA, Nae TAKATA, Manami KONISHI, Tatsunari TAKAHASHI
  • Publication number: 20220185969
    Abstract: The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.
    Type: Application
    Filed: April 15, 2019
    Publication date: June 16, 2022
    Applicants: NOF CORPORATION, UNIVERSITA' DEGLI STUDI DI PADOVA
    Inventors: Hiroki YOSHIOKA, Midori HIRAI, Masaki KAMIYA, Gianfranco PASUT
  • Patent number: 11342897
    Abstract: Hermeticity of an annular sealing bonding material to seal a vibrating part is improved. In the crystal resonator 10, a resonator-plate-side first bonding pattern 251 annularly formed on a crystal resonator plate 2 is bonded to a sealing-member-side first bonding pattern 321 annularly formed on a first sealing member 3, and a resonator-plate-side second bonding pattern 252 annularly formed on the crystal resonator plate 2 is bonded to a sealing-member-side second bonding pattern 421 annularly formed on a second sealing member 4. Thus, annular bonding materials 11a and 11b, which hermetically seal a vibrating part 22 causing piezoelectric resonance, are formed. Inner peripheral edge parts 111a and 111b and outer peripheral edge parts 112a and 112b of the bonding materials 11a and 11b are formed denser than intermediate parts 113a and 113b between the inner and outer peripheral edge parts 111a and 112a, and between the inner and outer peripheral edge parts 111b and 112b.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: May 24, 2022
    Assignee: Daishinku Corporation
    Inventor: Hiroki Yoshioka
  • Publication number: 20220153992
    Abstract: An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 19, 2022
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Kazuki OSAKAMA, Mika HAMURA, Takanori INABA, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Takahiro NOMOTO, Xiaohang SUN
  • Publication number: 20220077841
    Abstract: In a piezoelectric resonator device according to one or more embodiments, an internal space for hermetically sealing a vibrating part including a first excitation electrode and a second excitation electrode of a crystal resonator plate is formed by bonding a first sealing member and a second sealing member respectively to the crystal resonator plate. A through hole is formed in the second sealing member. A through electrode is formed along an inner wall surface of the through hole to establish conduction between an electrode formed on a first main surface and an external electrode terminal formed on a second main surface. A corrosion resistance structure to solder is formed on the through electrode that establishes conduction between the electrode and the external electrode terminal with a conductive metal other than Au.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 10, 2022
    Applicant: DAISHINKU CORPORATION
    Inventors: Satoru ISHINO, Hiroki YOSHIOKA, Hiroki FUJIWARA
  • Patent number: 11271293
    Abstract: An antenna device installed in a vehicle includes a stacked dipole antenna unit. The stacked dipole antenna unit has a plurality of dipole antennas that are arranged parallel to a plane perpendicular to a front-back direction of the vehicle.
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: March 8, 2022
    Assignee: MITSUMI ELECTRIC CO., LTD.
    Inventor: Hiroki Yoshioka
  • Patent number: 11220576
    Abstract: A degradable polyethylene glycol derivative represented by formula (1). R1, R2, and R4 represent each independently a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms, and at least one of R1, R2, R3 and R4 is the hydrocarbon group; P1 is a straight-chain or branched polyethylene glycol chain having a number of ethylene glycol units of 3 or more; P2 is a straight-chain polyethylene glycol chain having a number of ethylene glycol units of 3 or more; w is an integer of 1 to 8; u is an integer of 1 to 10; X1 is a chemically reactive functional group; and Z1, Z2 and Z3 are each independently a selected divalent spacer.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: January 11, 2022
    Assignee: NOF CORPORATION
    Inventors: Kota Tange, Hiroki Yoshioka, Takuma Tsubusaki, Masaki Kamiya
  • Publication number: 20210147624
    Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
    Type: Application
    Filed: March 29, 2019
    Publication date: May 20, 2021
    Applicants: NOF Corporation, Tokyo Institute of Technology
    Inventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA
  • Patent number: 10947343
    Abstract: A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: March 16, 2021
    Assignee: NOF CORPORATION
    Inventors: Hiroki Yoshioka, Yuji Yamamoto
  • Publication number: 20210023231
    Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Applicants: NOF CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Hiroki YOSHIOKA, Masaki KAMIYA, Yuji YAMAMOTO, Midori HIRAI, Akiko SASAKI, Nobuhiro NISHIYAMA, Makoto MATSUI, Hiroyasu TAKEMOTO, Kazuki MIYAUCHI, Takahiro NOMOTO, Keishiro TOMODA