Patents by Inventor Hiromichi Eto

Hiromichi Eto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6737434
    Abstract: Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: May 18, 2004
    Assignee: SSP Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Koji Kusano, Hiromichi Eto, Koichi Tachibana, Susumu Sato, Tadayoshi Taniyama
  • Publication number: 20030176482
    Abstract: Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R1 is lower alkyl; R2 is alkyl or aralkyl; and X1 is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.
    Type: Application
    Filed: March 19, 2003
    Publication date: September 18, 2003
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Koji Kusano, Hiromichi Eto, Koichi Tachinaba, Susumu Sato, Tadayoshi Taniyama
  • Patent number: 6528500
    Abstract: Described is an azole derivative represented by the following formula (1): wherein, R1 represents a substituted phenyl group, R2 and R3 each represents a fluorine atom, an alkyl group or the like, and R4 represents an alkyl group, or salt thereof; and a medicament comprising the derivative or salt as an effective ingredient. The compound according to the present invention exhibits excellent antimycotic action and has good aqueous solubility.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: March 4, 2003
    Assignee: SSP Co., Ltd.
    Inventors: Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6229049
    Abstract: The invention relates to a process for preparing a difluoroacetophenone derivative (4) by alkylthionating a compound (1) into a compound (2) and reacting this compound with a compound (3). wherein X1 is Cl, Br or I, X2 and X3 are independently a halogen atom, H or perfluoroalkyl group, X4 is a halogen atom, R1 is an alkyl, aryl or aralkyl group, and R2 is methyl, ethyl or cyclopropyl group.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: May 8, 2001
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Susumu Sato
  • Patent number: 6204415
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 20, 2001
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6194592
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: February 27, 2001
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6184396
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: February 6, 2001
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6172266
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X1 and X2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: January 9, 2001
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6171520
    Abstract: Disclosed are SH-labeling reagents containing acridine compounds represented by the following formula (I): wherein A represents the following group: —(CH2)m1— or —(CH2)m2—Q—(CH2)n— in which Q represents a group —S+RX−—, a group —N+RR1X−— wherein R1 represents an alkyl group having 1 to 6 carbon atoms or an aryl group, a group wherein R2 and R3 may be the same or different and are each independently a group —(CH2)k— (k: a number of 1 to 3) or —O(CH2CH2O)l— (l: a number of 1 to 3), m1 stands for a number of 1 to 6, m2 denotes a number of 0 to 2, n means a number of 1 to 2; R represents an alkyl group having 1 to 6 carbon atoms or an aryl group; and X− represents an anion, or intermediates thereof; preparation processes of the acridine compounds; and methods for labeling analytes by using the compounds.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 9, 2001
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Imai, Hiromichi Eto, Takeshi Kotsugai, Tadashi Narita
  • Patent number: 6083968
    Abstract: Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: July 4, 2000
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6063945
    Abstract: A compound having formula (2): ##STR1## wherein R represents hydrogen, a straight or branched C.sub.1-10 alkyl group, a C.sub.7-11 aralkyl group or a C.sub.2-10 carboacyl group and m stands for 1 to 5.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: May 16, 2000
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
  • Patent number: 6040325
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient.The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: March 21, 2000
    Assignee: SSP Co., Ltd.
    Inventors: Sunao Takeda, Yasushi Kaneko, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6028081
    Abstract: Substituted quinolone derivatives represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted (hetero)aryl group, R.sup.2 represents H or an alkoxycarbonyl, substituted aminocarbonyl, cyano or like group, and R.sup.3 and R.sup.4 each independently represent H or a substituted alkyl, aryl, amino or like group, and salts thereof; pharmaceuticals containing the same. These derivatives and salts have excellent anti-ulcer activities.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: February 22, 2000
    Assignee: SSP Co., Ltd.
    Inventors: Yoshihisa Sada, Shigeru Adegawa, Kinichi Mogi, Haruyoshi Honda, Hiromichi Eto, Shinichi Morimoto, Junji Okawa, Norimitsu Umehara, Susumu Sato
  • Patent number: 6008239
    Abstract: Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: December 28, 1999
    Assignee: SSP Co., Ltd.
    Inventors: Yasushi Kaneko, Sunao Takeda, Minoru Tokizawa, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato
  • Patent number: 6002028
    Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: December 14, 1999
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
  • Patent number: 5986144
    Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: November 16, 1999
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
  • Patent number: 5962509
    Abstract: Disclosed are dithiolylidene acetamide derivatives represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: October 5, 1999
    Assignee: SSP Co., Ltd.
    Inventors: Fumio Ishii, Kinichi Mogi, Hiromichi Eto, Susumu Sato, Hideaki Matsuda
  • Patent number: 5945438
    Abstract: Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: August 31, 1999
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
  • Patent number: 5939448
    Abstract: Described is a triazole derivative represented by the formula (1): wherein R represents a hydrogen atom, an alkyl group, an aralkyl group or an acyl group, n stands for 0 to 2 and m stands for 1 to 5 or salt thereof, and a pharmaceutical containing the derivative or salt as an effective ingredient.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: August 17, 1999
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Minoru Tokizawa, Sunao Takeda, Yasushi Kaneko, Hiromichi Eto, Kazuya Ishida, Kazunori Maebashi, Masaru Matsumoto, Takemitsu Asaoka, Susumu Sato, Hideaki Matsuda
  • Patent number: 4450109
    Abstract: The specification describes novel thiazinobenzimidazole derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and X represent a wide variety of substituent groups respectively. The above thiazinobenzimidazole derivatives may be prepared by reacting corresponding 2-hydroxymethyl thiazinobenzimidazole derivatives with corresponding reactive derivatives of carboxylic acid or halogenide or by reacting 2-p-toluenesulfonyloxymethyl-thiazinobenzimidazole derivatives with sodium azides, thiols, phenols or amines. The above thiazinobenzimidazole derivatives wherein X is OH may be prepared by reducing their corresponding 2-alkoxycarbonyl derivatives. Where X represents a p-toluenesulfonyloxy group, the thiazinobenzimidazole derivatives may be obtained by reacting corresponding 2-hydroxymethyl-thiazinobenzimidazole derivatives with p-toluenesulfonyl chloride.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: May 22, 1984
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Hiromichi Eto, Teruo Kohmoto, Tadayuki Kouda, Youichiro Ogawa, Susumu Sato, Tadayuki Kuraishi, Toshiaki Nakashima