Patents by Inventor Hiromu Murai

Hiromu Murai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4237132
    Abstract: A series of new 4,6-disubstituted 2-morpholinone derivatives were prepared either by a reaction of corresponding epoxide derivatives with phenylglycine derivatives or by the reaction of isopropanol derivatives with carboxylic acid derivatives. The new morpholinone derivatives are useful for the prevention or the treatment of arteriosclerosis.
    Type: Grant
    Filed: June 4, 1976
    Date of Patent: December 2, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
  • Patent number: 4210671
    Abstract: A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:HNRR'wherein R and R' are each hydrogen, a straight chain or branched alkyl group having 3 to 15 carbon atoms, a lower alkenyl group, a cycloalkyl group, a phenyl group, a phenylalkyl group and a phenylalkyl group having a lower alkyl group at the .alpha.-position, with the proviso that such amines where both R and R' are hydrogen or where one of R and R' is hydrogen and the other is phenyl are excluded.The invention further comprises the resulting abietamide derivative reaction products, compositions containing effective blood serum cholesterol-reducing amounts of said abietamide derivatives and their use as anti-arteriosclerotic agents.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: July 1, 1980
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 4182767
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy-N-alkylpiperidines and their acid addition salts are antihyperglycemic agents. A typical example is 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: January 8, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Ichiro Shirahase
  • Patent number: 4162331
    Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: July 24, 1979
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
  • Patent number: 4137231
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.
    Type: Grant
    Filed: December 20, 1976
    Date of Patent: January 30, 1979
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Yoshikuni, Tatsuhiko Kono, Masahiro Yagi
  • Patent number: 4117159
    Abstract: N-Phenyl and N-benzyl .DELTA..sup.8 -dihydropimaramides are antiphlogistic and serum cholesterol lowering agents. The compounds, of which N-(2-ethylphenyl)-.DELTA..sup.8 -dihydropimaramide is a representative embodiment, are prepared from reactive derivatives of .DELTA..sup.8 -dihydropimaric acid and the appropriate amine.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: September 26, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Yukio Fujita, Tamiki Mori, Hiroshi Enomoto, Yoshiaki Yoshikuni
  • Patent number: 4109000
    Abstract: 5-Benzy-2-pyridine carboxylic acids, in which the benzyl group is optionally substituted by one or two like or different alkyl, halo, alkoxy, nitro, amino, acetamido, hydroxy or acetoxy groups, and the corresponding amides and esters, possess dopamine .beta.-hydroxylase inhibitory properties and are useful as blood pressure lowering agents. The compounds, of which 5-(4-chlorobenzyl)-2-pyridine carboxylic acid, 5-(4-hydroxybenzyl)-2-pyridine carboxylic acid and 5-benzyl-2-pyridine carboxylic acid are typical examples, can be prepared by a number of chemical methods.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: August 22, 1978
    Assignees: Nippon Shinyaku Co., Ltd., Takara Shuzo Co., Ltd.
    Inventors: Osamu Tanabe, Akiro Obayashi, Teruya Nakamura, Osamu Suzuka, Masao Murayama, Hiromu Murai
  • Patent number: 4103009
    Abstract: 2,4-Diamino-6-phenyl-s-triazine derivatives which are substituted in the 3-position of the phenyl ring and optionally further substituted in the 6-position demonstrate anti-ulcer and diuretic properties. A representative embodiment is 2,4-diamino-6-(3-trifluoromethylthiophenyl)-s-triazine.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: July 25, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Yoshiaki Aoyagi, Fusao Ueda, Masahiko Kitano, Shinichi Tada
  • Patent number: 4100285
    Abstract: N-substituted trialkoxybenzyl piperazine derivatives expressed by the following general formula (I): ##STR1## where R represents a methyl or ethyl group, and Z represents a group selected from the group consisting of the following groups: isopropenyl group, cinnamyl group, morpholino ethyl group, diaminotriazine group, hydantoinbutyl group, ##STR2## where R represents the same as above, and n is an integer of 2 to 8, and ##STR3## where A represents a group selected from the group consisting of hydrogen, lower alkyl group, hydroxymethyl group, phenyl group, naphthyloxymethyl group and ##STR4## where Y represents a group selected from the group consisting of hydrogen, halogen, lower alkyl group, lower alkoxy group and hydroxy group.
    Type: Grant
    Filed: April 1, 1977
    Date of Patent: July 11, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Yoshiaki Aoyagi
  • Patent number: 4098892
    Abstract: The mono-, bis- and trisnicotinoyl derivatives of melamine and the corresponding mono- and bisnicotinoyl derivatives of benzoguanamine demonstrate anti-ulcer and diuretic activity. A representative embodiment is 2-nicotinamido-4,6-diamino-s-triazine.
    Type: Grant
    Filed: February 18, 1977
    Date of Patent: July 4, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Kenji Sempuku, Yoshiaki Aoyagi, Fusao Ueda
  • Patent number: 4094991
    Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: June 13, 1978
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
  • Patent number: 4064252
    Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
    Type: Grant
    Filed: June 4, 1976
    Date of Patent: December 20, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
  • Patent number: 4031303
    Abstract: Steryl-6-0-palmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-6-0-palmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-6-0-sulfonyl-.beta.-D-glucoside with an alkali metal salt of palmitic acid.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: June 21, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Masahiro Kise, Masahiko Kitano, Toshio Tomita
  • Patent number: 4024280
    Abstract: Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.
    Type: Grant
    Filed: May 12, 1975
    Date of Patent: May 17, 1977
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsuhide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 4009206
    Abstract: Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: February 22, 1977
    Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Kenji Sempuku, Koji Kitaguchi, Yukio Fujita, Yoshiaki Yoshikuni, Kohei Kura, Katsahide Saito, Tamiki Mori, Yasuo Yasutomi
  • Patent number: 3991186
    Abstract: Steryl-6-O-palnitoyl and -2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-.beta.-D-glucoside with a lower alkyl ester of palmitic acid in the presence of a basic catalyst.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: November 9, 1976
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Koji Kitaguchi, Tatsuo Suminokura, Akira Sano, Massahiro Kise, Masahiko Kitano, Toshio Tomita
  • Patent number: 3966728
    Abstract: A series of novel benzoguanamine derivatives possessing a high anti-peptic ulcer activity with low toxicity has been prepared by the reaction of the corresponding dihalogenobenzonitriles with dicyandiamide or by the reaction of the corresponding carboxylic acids or functional derivatives thereof with biguanide.
    Type: Grant
    Filed: January 27, 1975
    Date of Patent: June 29, 1976
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Katsuya Ohata, Yoshiaki Aoyagi, Fusao Ueda, Masahiko Kitano, Satoshi Takata, Shinichi Tada