Patents by Inventor Hiroshi Kawabata
Hiroshi Kawabata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11933543Abstract: A heat sink includes: a container having a cavity inside and a first surface and a second surface opposite the first surface; a working fluid encapsulated in the cavity; and a steam flow path in the cavity where the working fluid in a gas phase flows, the first surface having a flat part and a protruding part projecting from the flat part in an external direction, causing the container to have a flat portion and a protruding portion projecting from the flat portion in the external direction, an inner space of the protruding portion of the container being in communication with an inner space of the flat portion, causing the cavity to be formed, and a first heat radiating fin being provided on an exterior of the flat part of the first surface and a second heat radiating fin being provided on an exterior of the second surface.Type: GrantFiled: October 21, 2022Date of Patent: March 19, 2024Assignee: FURUKAWA ELECTRIC CO., LTD.Inventors: Kenya Kawabata, Masahiro Meguro, Ryo Tsubata, Hirofumi Aoki, Yoshikatsu Inagaki, Hiroshi Sakai, Hideaki Kawabata
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Publication number: 20230323317Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.Type: ApplicationFiled: December 30, 2022Publication date: October 12, 2023Applicant: API CORPORATIONInventors: Toyokazu YOSHIDA, Koichi ISHIDA, Ryoma MIYAKE, Takanobu IURA, Hiroshi KAWABATA
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Publication number: 20230265475Abstract: A method of producing high-purity hydroxy-L-pipecolic acids that includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase (1) acts on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.Type: ApplicationFiled: January 20, 2023Publication date: August 24, 2023Applicant: API CORPORATIONInventors: Ryoma MIYAKE, Hiroshi KAWABATA
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Patent number: 11591577Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.Type: GrantFiled: February 17, 2021Date of Patent: February 28, 2023Assignee: API CORPORATIONInventors: Ryoma Miyake, Hiroshi Kawabata
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Patent number: 11572551Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.Type: GrantFiled: March 29, 2019Date of Patent: February 7, 2023Assignee: API CORPORATIONInventors: Toyokazu Yoshida, Koichi Ishida, Ryoma Miyake, Takanobu Iura, Hiroshi Kawabata
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Publication number: 20220275410Abstract: An object of the present invention is to provide a method of industrially producing a high-purity L-cyclic amino acid more inexpensively and with a high efficiency, from a cyclic amino acid having a double bond at the 1-position. The present invention provides a method in which an L-cyclic amino acid is produced by allowing a cyclic amino acid having a double bond at the 1-position to react with a specific enzyme having a catalytic ability to reduce a cyclic amino acid having a double bond at the 1-position to produce an L-cyclic amino acid.Type: ApplicationFiled: May 15, 2020Publication date: September 1, 2022Applicant: API CORPORATIONInventors: Masaharu MIZUTANI, Ryoma MIYAKE, Hiroshi KAWABATA
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Publication number: 20220212506Abstract: A pneumatic tire comprises a tread portion, sidewall portions, bead portions each with a bead core embedded therein, and a carcass extending between the bead portions and comprising first carcass cords and second carcass cords. The first carcass cord comprises: a main portion extending from the tread portion to the bead portions via the sidewall portions; and folded-back portions continued from the main portion and folded back around the bead cores from the inside to the outside in the tire axial direction. The second carcass cord extends from the tread portion to the bead portions and terminates on the axially outside of the folded-back portions of the first carcass cords. Young's modulus of the second carcass cords is larger than Young's modulus of the first carcass cords.Type: ApplicationFiled: December 22, 2021Publication date: July 7, 2022Applicant: Sumitomo Rubber Industries, Ltd.Inventor: Hiroshi KAWABATA
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Patent number: 11136560Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence repType: GrantFiled: April 6, 2018Date of Patent: October 5, 2021Assignee: API CORPORATIONInventors: Makoto Hibi, Jun Ogawa, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20210269495Abstract: The purpose of the present invention is to provide a modified activin A. The present invention provides activin A comprising a modified proregion.Type: ApplicationFiled: May 14, 2021Publication date: September 2, 2021Applicants: Mitsubishi Chemical Corporation, UniBio CorporationInventors: HIDEHITO TAKAYAMA, Risa Watanabe, Yutaka Takemoto, Hiroyuki Tanaka, Hiroshi Kawabata, Kyoji Yoshinaka
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Publication number: 20210180097Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.Type: ApplicationFiled: February 17, 2021Publication date: June 17, 2021Applicant: API CORPORATIONInventors: Ryoma MIYAKE, Hiroshi KAWABATA
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Patent number: 10954539Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.Type: GrantFiled: September 30, 2016Date of Patent: March 23, 2021Assignee: API CORPORATIONInventors: Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20210024905Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.Type: ApplicationFiled: March 29, 2019Publication date: January 28, 2021Applicant: API CORPORATIONInventors: Toyokazu YOSHIDA, Koichi ISHIDA, Ryoma MIYAKE, Takanobu IURA, Hiroshi KAWABATA
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Publication number: 20190315696Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: ApplicationFiled: June 17, 2019Publication date: October 17, 2019Applicant: API CORPORATIONInventors: Naoyuki WATANABE, Tomoko MAEDA, Yasumasa DEKISHIMA, Hiroshi KAWABATA, Masaki NAGAHAMA
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Patent number: 10377722Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.Type: GrantFiled: May 19, 2017Date of Patent: August 13, 2019Assignee: API CORPORATIONInventors: Naoyuki Watanabe, Tomoko Maeda, Yasumasa Dekishima, Hiroshi Kawabata, Masaki Nagahama, Kosuke Ito
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Patent number: 10327383Abstract: A mid-mount mower has a mower unit mounted under a vehicle body between front wheels and rear wheels. The mower includes a lift link mechanism having a front link and a rear link, an intermediate structure interconnecting one end of the front link and one end of the rear link via a pivot axis, a blade housing having an engaged portion engageable with an engaging potion of the intermediate structure and a guide face configured to guide the engaging portion ad the engaged portion to an engaging position so as to establish connection between the blade housing placed on a ground surface and the intermediate structure in association with a movement of the vehicle body in a front/rear direction.Type: GrantFiled: March 10, 2017Date of Patent: June 25, 2019Assignee: Kubota CorporationInventors: Hiroyuki Tada, Akira Minoura, Takeshi Komorida, Azusa Furihata, Hiroshi Kawabata, Ryo Matsumoto
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Patent number: 10208203Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition, mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom, or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.Type: GrantFiled: November 10, 2017Date of Patent: February 19, 2019Assignee: NIPPON SHOKUBAI CO., LTD.Inventor: Hiroshi Kawabata
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Publication number: 20180282709Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence repType: ApplicationFiled: April 6, 2018Publication date: October 4, 2018Applicant: API CORPORATIONInventors: Makoto HIBI, Jun OGAWA, Ryoma MIYAKE, Hiroshi KAWABATA
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Publication number: 20180273993Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.Type: ApplicationFiled: September 30, 2016Publication date: September 27, 2018Applicant: API CORPORATIONInventors: Ryoma MIYAKE, Hiroshi KAWABATA
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Patent number: 10071958Abstract: According to the present invention, it becomes possible to perform a process for converting into an ?-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance.Type: GrantFiled: May 1, 2014Date of Patent: September 11, 2018Assignee: API CorporationInventors: Yuuki Asuma, Hisatoshi Uehara, Tomoko Maeda, Yasuyo Saito, Ryoma Miyake, Hiroshi Kawabata
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Publication number: 20180251424Abstract: According to the present invention, it becomes possible to perform a process for converting into an ?-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance.Type: ApplicationFiled: May 14, 2018Publication date: September 6, 2018Inventors: Yuuki Asuma, Hisatoshi Uehara, Tomoko Maeda, Yasuyo Saito, Ryoma Miyake, Hiroshi Kawabata