Patents by Inventor Hiroshi Kawabata

Hiroshi Kawabata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11136560
    Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence rep
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: October 5, 2021
    Assignee: API CORPORATION
    Inventors: Makoto Hibi, Jun Ogawa, Ryoma Miyake, Hiroshi Kawabata
  • Publication number: 20210290143
    Abstract: A bioelectric current estimation method includes acquiring position information of a nerve in a measurement target region of a subject for which magnetic data is measured with a magnetic sensor, the position information of the nerve being acquired based on a nerve image included in a morphological image of the measurement target region; acquiring a positional relationship between a position of the nerve and a position of the magnetic sensor, based on the acquired position information of the nerve and position information of the magnetic sensor when the magnetic sensor is positioned to face the measurement target region; and estimating a neural activity current, which is generated in association with neural activity of the subject, based on the acquired positional relationship and the magnetic data of the measurement target region measured by the magnetic sensor.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 23, 2021
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Taishi WATANABE, Shigenori KAWABATA, Takanori YOKOTA, Miho AKAZA, Hiroshi DEGUCHI, Sukchan KIM, Yuki MIYANO
  • Patent number: 11123037
    Abstract: An X-ray imaging apparatus includes an X-ray source, a detector for detecting X-rays, an imaging unit, an operation unit, a notification unit, and a control unit. The control unit generates an image of an inside of an examination room. Further, when detecting that a person other than a subject is present in the examination room based on the image of the inside of the examination room, the control unit performs control to issue caution information indicating that a person other than a subject is present in the examination room.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: September 21, 2021
    Assignee: Shimadzu Corporation
    Inventors: Hiroshi Okumura, Ken Shirota, Junpei Sakaguchi, Toshiya Kawabata
  • Publication number: 20210269495
    Abstract: The purpose of the present invention is to provide a modified activin A. The present invention provides activin A comprising a modified proregion.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Applicants: Mitsubishi Chemical Corporation, UniBio Corporation
    Inventors: HIDEHITO TAKAYAMA, Risa Watanabe, Yutaka Takemoto, Hiroyuki Tanaka, Hiroshi Kawabata, Kyoji Yoshinaka
  • Publication number: 20210180097
    Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 17, 2021
    Applicant: API CORPORATION
    Inventors: Ryoma MIYAKE, Hiroshi KAWABATA
  • Patent number: 10954539
    Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 23, 2021
    Assignee: API CORPORATION
    Inventors: Ryoma Miyake, Hiroshi Kawabata
  • Publication number: 20210024905
    Abstract: The present invention provides a novel hydrolase that can industrially produce optically highly pure (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid with high efficiency at low costs, and a production method using the hydrolase.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Applicant: API CORPORATION
    Inventors: Toyokazu YOSHIDA, Koichi ISHIDA, Ryoma MIYAKE, Takanobu IURA, Hiroshi KAWABATA
  • Publication number: 20190315696
    Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 17, 2019
    Applicant: API CORPORATION
    Inventors: Naoyuki WATANABE, Tomoko MAEDA, Yasumasa DEKISHIMA, Hiroshi KAWABATA, Masaki NAGAHAMA
  • Patent number: 10377722
    Abstract: An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high purity at an industrial scale, without using an extremely low temperature reaction or a special asymmetric catalyst.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 13, 2019
    Assignee: API CORPORATION
    Inventors: Naoyuki Watanabe, Tomoko Maeda, Yasumasa Dekishima, Hiroshi Kawabata, Masaki Nagahama, Kosuke Ito
  • Patent number: 10327383
    Abstract: A mid-mount mower has a mower unit mounted under a vehicle body between front wheels and rear wheels. The mower includes a lift link mechanism having a front link and a rear link, an intermediate structure interconnecting one end of the front link and one end of the rear link via a pivot axis, a blade housing having an engaged portion engageable with an engaging potion of the intermediate structure and a guide face configured to guide the engaging portion ad the engaged portion to an engaging position so as to establish connection between the blade housing placed on a ground surface and the intermediate structure in association with a movement of the vehicle body in a front/rear direction.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: June 25, 2019
    Assignee: Kubota Corporation
    Inventors: Hiroyuki Tada, Akira Minoura, Takeshi Komorida, Azusa Furihata, Hiroshi Kawabata, Ryo Matsumoto
  • Patent number: 10208203
    Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition, mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom, or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: February 19, 2019
    Assignee: NIPPON SHOKUBAI CO., LTD.
    Inventor: Hiroshi Kawabata
  • Publication number: 20180282709
    Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence rep
    Type: Application
    Filed: April 6, 2018
    Publication date: October 4, 2018
    Applicant: API CORPORATION
    Inventors: Makoto HIBI, Jun OGAWA, Ryoma MIYAKE, Hiroshi KAWABATA
  • Publication number: 20180273993
    Abstract: A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties: (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 27, 2018
    Applicant: API CORPORATION
    Inventors: Ryoma MIYAKE, Hiroshi KAWABATA
  • Patent number: 10071958
    Abstract: According to the present invention, it becomes possible to perform a process for converting into an ?-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: September 11, 2018
    Assignee: API Corporation
    Inventors: Yuuki Asuma, Hisatoshi Uehara, Tomoko Maeda, Yasuyo Saito, Ryoma Miyake, Hiroshi Kawabata
  • Publication number: 20180251424
    Abstract: According to the present invention, it becomes possible to perform a process for converting into an ?-substituted cysteine represented by general formula (1) or a salt thereof at low cost and on an industrial scale by employing a process that is routed through a compound represented by general formula (3) to a compound represented by general formula (6). Particularly, by employing a process that is routed through a compound represented by general formula (7-2), it becomes possible to detach a tert-butyl protection group in a simple manner and to produce the compound represented by general formula (1) with high purity. Furthermore, by employing a process that is routed through tert-butylthiomethanol or a process that is routed through a compound represented by general formula (9), it becomes possible to produce a compound represented by general formula (2) without generating bischloromethylether that is an oncogenic substance.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 6, 2018
    Inventors: Yuuki Asuma, Hisatoshi Uehara, Tomoko Maeda, Yasuyo Saito, Ryoma Miyake, Hiroshi Kawabata
  • Patent number: 10029731
    Abstract: A work vehicle includes a prime mover unit disposed in a front part of the vehicle body, a driving part located in a rear part of the vehicle body, a battery disposed between the prime mover unit and the driving part, a base frame disposed in a lower part of the vehicle body and a center pillar that extends upward from the base frame. The prime mover unit includes a radiator disposed immediately forward of the center pillar.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: July 24, 2018
    Assignee: Kubota Corporation
    Inventors: Koichiro Matsumoto, Shoichiro Nagaishi, Ryo Matsumoto, Hiroshi Kawabata, Hiroki Nagai, Masahiro Izumi, Masaki Takaoka, Tasuku Teraoka, Takashi Kumashiro
  • Patent number: 9969988
    Abstract: The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with ?-amino acid to produce 4-hydroxy amino acid: (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18; (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence rep
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: May 15, 2018
    Assignee: API CORPORATION
    Inventors: Makoto Hibi, Jun Ogawa, Ryoma Miyake, Hiroshi Kawabata
  • Publication number: 20180086912
    Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2 ??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition, mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom, or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 29, 2018
    Inventor: Hiroshi KAWABATA
  • Patent number: 9914487
    Abstract: A work vehicle includes: a vehicle body frame; a prime mover part that is supported by the vehicle body frame; a bonnet that is configured to vertically swing between a closed position at which the prime mover part is covered, and an open position at which the prime mover part is open; and a support frame that supports a free end side of the bonnet located at the closed position. At least left and right guide-target parts of the bonnet or left and right guiding parts of the support frame have left and right inclined surfaces that serve as centering effective surfaces.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: March 13, 2018
    Assignee: Kubota Corporation
    Inventors: Koichiro Matsumoto, Nobuyuki Yamashita, Hiroshi Kawabata, Tomohisa Yamamoto, Masayuki Akita, Tasuku Teraoka, Yoshihisa Tonoya
  • Patent number: 9850378
    Abstract: A monomer composition containing an unsaturated polyalkylene glycol ether-based monomer is provided having excellent stability. The monomer composition contains an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R1O)nR2??(1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R1O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition mole number of oxyalkylene groups and is a number of 5 to 500; and R2 represents a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 26, 2017
    Assignee: Nippon Shokubai Co., Ltd.
    Inventor: Hiroshi Kawabata