Patents by Inventor Hiroshi Namisaki

Hiroshi Namisaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding an anti-CD40 IgG2 antibody having amino acid mutations
    Patent number: 9587031
    Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: March 7, 2017
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Aki Matsushima, Hiroshi Namisaki, Shigenori Yagi
  • ANTIBODY CONTAINING IGG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN
    Publication number: 20160075792
    Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
    Type: Application
    Filed: November 25, 2015
    Publication date: March 17, 2016
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Aki MATSUSHIMA, Hiroshi NAMISAKI, Shigenori YAGI
  • Agonistic anti-CD40 IGG2 antibodies having amino acid mutations introduced therein
    Patent number: 9234044
    Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: January 12, 2016
    Assignee: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Aki Matsushima, Hiroshi Namisaki, Shigenori Yagi
  • ANTIBODY CONTAINING IGG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN
    Publication number: 20120087927
    Abstract: The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
    Type: Application
    Filed: April 20, 2010
    Publication date: April 12, 2012
    Applicant: KYOWA HAKKO KIRIN CO., LTD
    Inventors: Aki Matsushima, Hiroshi Namisaki, Shigenori Yagi