Patents by Inventor Hiroshi Tomoda
Hiroshi Tomoda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110184173Abstract: The present invention is a compound having the general formula (I), (II), or (III) or a pharmacologically acceptable salt, solvate, or hydrate thereof, and a pharmaceutical composition containing such a compound, or its pharmacologically acceptable ester, or other pharmacologically acceptable derivative thereof as an active ingredient. The compound has an excellent ACAT 2-inhibiting activity by a mechanism different from that of a statin drug and is useful as a therapeutic or prophylactic agent for obesity, adiposis, hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, and arteriosclerosis, as well as obesity-derived hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, arteriosclerosis, and hypertension.Type: ApplicationFiled: December 17, 2008Publication date: July 28, 2011Applicant: THE KITASATO INSTITUTEInventors: Hiroshi Tomoda, Tohru Nagamitsu, Satoshi Omura
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Patent number: 7982057Abstract: The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.Type: GrantFiled: March 15, 2006Date of Patent: July 19, 2011Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda
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Patent number: 7973147Abstract: A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including ?-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of ?-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including ?-lactam antibiotics resistant bacteria.Type: GrantFiled: May 16, 2006Date of Patent: July 5, 2011Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Yong-pil Kim, Hideaki Hanaki, Atsuko Matsumoto, Yoko Takahashi
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Publication number: 20110105769Abstract: This invention relates to substance FKI-3864 represented by the following formula [I] having an inhibitory activity on the synthesis of triacylglycerols and a method for preparing the same. The substance FKI-3864 can be prepared by a method comprising culturing a microorganism which belongs to the genus Penicillium and is capable of producing the substance FKI-3864, and particularly Penicillium pinophilum FKI-3864 (FERM BP-11093) so as to accumulate the substance FKI-3864 in the culture and collecting the substance FKI-3864 from the culture. The substance has an inhibitory activity on the synthesis of intracellular triacylglycerols and is useful for prevention or treatment of obesity.Type: ApplicationFiled: February 12, 2009Publication date: May 5, 2011Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTEInventors: Hiroshi Tomoda, Ryuji Uchida, Rokuro Masuma, Satoshi Omura
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Publication number: 20110034404Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: ApplicationFiled: October 13, 2010Publication date: February 10, 2011Inventors: Kimihiko GOTO, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Patent number: 7838538Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: GrantFiled: December 23, 2008Date of Patent: November 23, 2010Assignees: Meiji Seika Kaisha, Ltd., The Kitasato InstituteInventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Publication number: 20100291622Abstract: The present invention provides compounds which exhibit an inhibitory effect on undecaprenyl diphosphate synthase of microbes and thereby they are expected to be used clinically as pharmaceutical agents for infectious diseases caused by bacteria. The process comprises culturing a microbe belonging to Penicillium and having ability of producing an FKI-3368 substance in or on a nutrient medium to accumulate the FKI-3368 substance in the nutrient medium and collecting the FKI-3368 substance from the culture.Type: ApplicationFiled: September 12, 2008Publication date: November 18, 2010Applicant: SCHOOL JURIDICAL PERSON KITASATO INSTITUTEInventors: Hiroshi Tomoda, Junji Inokoshi, Rokuro Masuma, Satoshi Omura
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Patent number: 7794991Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.Type: GrantFiled: October 3, 2005Date of Patent: September 14, 2010Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Publication number: 20090137634Abstract: Disclosed is a composition for use as a pest control agent, comprising a compound represented by formula (I) or an agriculturally and horticulturally acceptable salt thereof as active ingredient and an agriculturally and horticulturally acceptable carrier:Type: ApplicationFiled: December 23, 2008Publication date: May 28, 2009Inventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Publication number: 20090130717Abstract: A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as the therapeutic agents for infectious disease caused by MRSA as well as infectious diseases caused by multidrug including ?-lactam antibiotics resistant bacteria. Further, similarly, since the novel K04-0144D substance isolated from the cultured liquid has the action for enhancing the effect of ?-lactam antibiotics, which are utilized as the antibacterial agents, in combination with them, it is useful as the therapeutic agent for infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and multidrug including ?-lactam antibiotics resistant bacteria.Type: ApplicationFiled: May 16, 2006Publication date: May 21, 2009Inventors: Satoshi Omura, Hiroshi Tomoda, Yong-pil Kim, Hideaki Hanaki, Atsuko Matsumoto, Yoko Takahashi
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Patent number: 7521428Abstract: Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of appearance of resistant microorganisms. One such substance is a compound represented by the formula [I]: wherein R1 is Ac, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is H, when R1 Bzl, R2 and R3 are Bzl, and R4 is Me; when R1 is Ac, R2 and R3 are Pr, and R4 is Me; when R1 is Ac, R2 and R3 are Hex, and R4 is Me; when R1 is Ac, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 and R3 are Pr, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is Me; when R1 is H, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 is H, R3 is Bzl, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is H, or when R1 is H, R2 and R3 are Hex, and R4 is Et.Type: GrantFiled: October 29, 2002Date of Patent: April 21, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka, Masayoshi Arai, Tohru Nagamitsu
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Publication number: 20090093646Abstract: The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.Type: ApplicationFiled: March 15, 2006Publication date: April 9, 2009Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda
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Patent number: 7514455Abstract: An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor.Type: GrantFiled: June 10, 2002Date of Patent: April 7, 2009Assignee: The Kitasato InstituteInventors: Satoshi Omura, Kazuro Shiomi, Hiroshi Tomoda, Rokuro Masuma, Kiyoshi Kita
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Patent number: 7491738Abstract: There is provided a pest control agent comprising a compound represented by formula (I) as active ingredient.Type: GrantFiled: May 31, 2006Date of Patent: February 17, 2009Assignees: Meiji Seika Kaisha, Ltd., The Kitasato Institute (A School Juridical Person)Inventors: Kimihiko Goto, Ryo Horikoshi, Mariko Tsuchida, Kazuhiko Oyama, Satoshi Omura, Hiroshi Tomoda, Toshiaki Sunazuka
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Publication number: 20080318842Abstract: [Problems] To provide a novel cyclic isodityrosine derivative having a physiological effect. [Means for solving problems] A compound represented by general formula (I) or a pharmacologically acceptable salt thereof has an effect of potentiating activity of imipenem, an effect of inhibiting the synthesis of a cholesteryl ester, and so forth: wherein R1 represents a hydrogen atom, an amido group, a Boc group, a Cbz group, an Fmoc group, a BocNH(CH2)5CO— group, a BocNHCH(CH2C6H5)CO— group, or a linear or branched alkyl group; R2 represents a benzoyl group, a benzyl group, a modified benzyl group, or a linear or branched alkyl group; R3 represents a hydrogen group, an —OR5 group, wherein R5 represents a linear or branched alkyl group or an aromatic ring, or an amido group; R4 represents a hydrogen atom, or a linear or branched alkyl group; and X1 and X2 each represent a halogen atom, wherein X1 and X2 may be the same as or different from each other.Type: ApplicationFiled: September 30, 2005Publication date: December 25, 2008Inventors: Shigeru Nishiyama, Rika Obata, Hiroshi Tomoda
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Patent number: 7439225Abstract: The present invention is comprised of culturing a microorganism having ability to produce K01-B0171-B substance and/or K01-B0171-C substance in a medium, accumulating K01-B0171-B substance and/or K01-B0171-C substance in a culture fluid and isolating K01-B0171-B substance and/or, K01-B0171-C substance from the culture fluid. The obtained K01-B0171-B substance, K01-B0171-C substance or a composition of these substances is expected to be useful as a medicament of antituberculous agent.Type: GrantFiled: January 17, 2003Date of Patent: October 21, 2008Assignee: The Kitasato InstituteInventors: Satoshi Omura, Hiroshi Tomoda, Masato Iwatsuki, Yoko Takahashi
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Publication number: 20080160587Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.Type: ApplicationFiled: October 3, 2005Publication date: July 3, 2008Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Patent number: 7192742Abstract: (Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 substances in the liquid culture medium. Then the FO-6979-M0, -M1, -M2, -M3 and -M4 substances are collected from the culture medium. The substances thus obtained are less toxic, specifically inhibit acyl-Coenzyme A: cholesterol acyltransferase, and inhibit the formation of oil droplets in macrophages. Owing to these characteristics, the above substances are useful in preventing and treating human diseases caused by cholesterol accumulation.Type: GrantFiled: March 19, 2002Date of Patent: March 20, 2007Assignees: Gakkou Houjin Kitasato Gakeun, Japan Society for the Promotion of ScienceInventors: Satoshi Omura, Hiroshi Tomoda
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Publication number: 20070032545Abstract: A microorganism belonging to filamentous fungi, capable of producing antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D is cultured in a culture medium to thereby accumulate the antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D in the culture mixture. The antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D is collected from the culture mixture. The thus obtained substance is promising as drugs, veterinary medicines or agrichemicals having a growth inhibiting activity to microorganisms, nematodes and arthropods or as drugs exhibiting a growth inhibiting activity to carcinoma cells.Type: ApplicationFiled: March 24, 2004Publication date: February 8, 2007Inventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
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Publication number: 20060287252Abstract: A microorganism belonging to the genus Streptomyces and being capable of producing substance K01-0509-A1 and/or substance K01-0509-A2 is cultured in a medium. Then, the substance K01-0509-A1 and/or the substance K01-0509-A2 having been thus accumulated in the liquid culture medium are collected from the medium. It is expected that the obtained substances are efficacious as drugs which are selectively effective on pathogenic gram-negative bacteria having the type III secretion system.Type: ApplicationFiled: February 9, 2004Publication date: December 21, 2006Inventors: Satoshi Omura, Akio Abe, Masato Iwatuki, Yoko Takahashi, Hiroshi Tomoda