Patents by Inventor Hirotaka James Okano

Hirotaka James Okano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11147248
    Abstract: A method for producing a new deafness model animal and a new deafness model animal produced by the method, enabling research that can also be applied to clinical application to a human. The present invention provides a method for producing an acoustic trauma deafness model animal, the method including exposing a non-human primate animal to a sound having a frequency of 1 kHz to 32 kHz and a sound pressure level of 100 dB to 150 dB for 10 minutes to 360 minutes. In addition, the present invention provides an acoustic trauma deafness model animal provided by the method for producing an acoustic trauma deafness model animal.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: October 19, 2021
    Assignees: KEIO UNIVERSITY, THE JIKEI UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Masato Fujioka, Hirotaka James Okano, Hiromi Kojima, Sho Kurihara, Tomohiko Yoshida
  • Publication number: 20190174728
    Abstract: A method for producing a new deafness model animal and a new deafness model animal produced by the method, enabling research that can also be applied to clinical application to a human. The present invention provides a method for producing an acoustic trauma deafness model animal, the method including exposing a non-human primate animal to a sound having a frequency of 1 kHz to 32 kHz and a sound pressure level of 100 dB to 150 dB for 10 minutes to 360 minutes. In addition, the present invention provides an acoustic trauma deafness model animal provided by the method for producing an acoustic trauma deafness model animal.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 13, 2019
    Inventors: Masato Fujioka, Hirotaka James Okano, Hiromi Kojima, Sho Kurihara, Tomohiko Yoshida
  • Publication number: 20150173330
    Abstract: To generate an animal model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration. An animal model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration can be produced by means of generating a mutation in a vertebrate so that expression of a mutant protein with a substitution of tyrosine for alanine at a position corresponding to position 382 of SEQ ID NO. 1 or a mutant protein with a substitution of cysteine for glycine at a position corresponding to position 348 of SEQ ID NO. 1 is regulated by an endogenous TDP-43 gene promoter in at least one allele of an endogenous TDP-43 gene of the vertebrate.
    Type: Application
    Filed: May 30, 2013
    Publication date: June 25, 2015
    Inventors: Hideyuki Okano, Hirotaka James Okano, Chikako Miyauchi
  • Patent number: 7498031
    Abstract: A therapeutic and/or preventive agent for inner ear disorders comprising an IL-6 antagonist, preferably an anti-IL-6R antibody, as an active ingredient.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: March 3, 2009
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Keio University
    Inventors: Masato Fujioka, Hirotaka James Okano, Kaoru Ogawa, Hideyuki Okano, Sho Kanzaki