Patents by Inventor Hiroyuki Chiku

Hiroyuki Chiku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160069909
    Abstract: The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 10, 2016
    Applicant: FUJIFILM CORPORATION
    Inventors: Kazuhiro NAKAMURA, Noriyuki KASAGI, Hiroyuki CHIKU, Kentaro NAKAMURA
  • Patent number: 8877515
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: November 4, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Hiroyuki Chiku, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Publication number: 20140295468
    Abstract: The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry particles that are modified with second binding substances not exhibiting binding properties specific to the test substance, have an average particle size of 100 nm to 200 nm, and do not have labels with (c) a test sample solution containing the test substance; (ii) applying the mixed solution onto a substrate; (iii) causing the test substance to be trapped in a reaction site on the substrate that has third binding substances having binding properties specific to the test substance or has substances exhibiting binding properties to the first binding substances; and (iv) detecting the test substance.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 2, 2014
    Applicant: FUJIFILM Corporation
    Inventors: Noriyuki KASAGI, Hiroyuki CHIKU, Dai UJIHARA, Toshihide YOSHITANI
  • Patent number: 8716032
    Abstract: The present invention is to provide an immunochromatography method which is capable of performing a detection with high-sensitivity or reduced false-positives by suppressing the occurrence of false-positive when a signal is amplified. An immunochromatography method includes in a state of where a complex of a test substance and a labeling substance containing a metal coupled with a first binding substance for the test substance is formed, developing the complex on an insoluble carrier in presence of a protease hydrolyzate of protein; capturing the test substance and the labeling substance at a detection site of the insoluble carrier containing a material which has a binding property to the first binding substance for the test substance or a second binding substance for the test substance; and detecting the test substance by amplifying the labeling substance captured.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: May 6, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hiroyuki Chiku
  • Patent number: 8663910
    Abstract: A plurality of kinds of liquids, which are of at least three kinds, containing (a) a test body solution containing at least one kind of an analyte, and (b) at least two kinds of liquids selected from the group consisting of a reagent solution, an amplifying solution, and a detecting solution, are fed to a detection site containing a specific binding substance with respect to the analyte. A qualitative analysis or a quantitative analysis of the analyte contained in the test body solution is thereby performed. Directions of liquid feeding of all of the plurality of the kinds of the liquids vary from one another, and the plurality of the kinds of the liquids are caused to intersect with one another at the detection site.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: March 4, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Mikinaga Mori, Junichi Katada, Hiroyuki Chiku, Takayoshi Oyamada
  • Publication number: 20120322165
    Abstract: The present invention is to provide an immunochromatography method which is capable of performing a detection with high-sensitivity or reduced false-positives by suppressing the occurrence of false-positive when a signal is amplified. An immunochromatography method includes in a state of forming a complex from a test substance and a labeling substance containing a metal modified with a first binding substance for the test substance, developing the complex on an insoluble carrier in presence of a protease hydrolyzate of protein; capturing the test substance and the labeling substance in a detection site on the insoluble carrier containing a substance which has a binding property to a second binding substance for the test substance or the first binding substance for the test substance; and detecting the test substance by amplifying the labeling substance captured.
    Type: Application
    Filed: June 14, 2012
    Publication date: December 20, 2012
    Applicant: FUJIFILM CORPORATION
    Inventors: Junichi KATADA, Hiroyuki CHIKU
  • Patent number: 8173444
    Abstract: An object of the present invention is to provide a metal particle with which a highly-sensitive testing method can be conducted, and a testing method using such metal particle. The present invention provides a metal particle, which is produced by coating a metal particle labeled with a molecule binding to an analyte with a mixture of two or more types of water-soluble polymer having a mercapto group, a dithiol group or a sulfide group and differing in molecular weight.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: May 8, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Bo Yang, Hiroyuki Chiku
  • Publication number: 20110269247
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.
    Type: Application
    Filed: July 7, 2011
    Publication date: November 3, 2011
    Inventors: Hiroyuki CHIKU, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Patent number: 7998753
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: August 16, 2011
    Assignee: Fujifilm Corporation
    Inventors: Hiroyuki Chiku, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Patent number: 7935541
    Abstract: An object of the present invention is to overcome the problem of nonspecific adsorption of a labeled antibody on the detection site and to provide an immunochromatography method by which the false positive signal can be suppressed, and wherein the detection sensitivity is high and the highly reliable measurement can be performed.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 3, 2011
    Assignee: Fujifilm Corporation
    Inventor: Hiroyuki Chiku
  • Publication number: 20100075440
    Abstract: A plurality of kinds of liquids, which are of at least three kinds, containing (a) a test body solution containing at least one kind of an analyte, and (b) at least two kinds of liquids selected from the group consisting of a reagent solution, an amplifying solution, and a detecting solution, are fed to a detection site containing a specific binding substance with respect to the analyte. A qualitative analysis or a quantitative analysis of the analyte contained in the test body solution is thereby performed. Directions of liquid feeding of all of the plurality of the kinds of the liquids vary from one another, and the plurality of the kinds of the liquids are caused to intersect with one another at the detection site.
    Type: Application
    Filed: September 18, 2009
    Publication date: March 25, 2010
    Inventors: Mikinaga MORI, Jinichi Katada, Hiroyuki Chiku, Takayoshi Oyamada
  • Publication number: 20090203153
    Abstract: An object of the present invention is to provide a metal particle with which a highly-sensitive testing method can be conducted, and a testing method using such metal particle. The present invention provides a metal particle, which is produced by coating a metal particle labeled with a molecule binding to an analyte with a mixture of two or more types of water-soluble polymer having a mercapto group, a dithiol group or a sulfide group and differing in molecular weight.
    Type: Application
    Filed: February 11, 2009
    Publication date: August 13, 2009
    Inventors: Bo YANG, Hiroyuki CHIKU
  • Publication number: 20090203155
    Abstract: An object of the present invention is to provide a labeled particle having a high reactivity with an antigen and a suppressed non-specific adsorption, and an immunochromatographic method using the labeled particle. The present invention provides a labeled particle, wherein a fragmented antibody is immobilized to a labeling substance via a chemical bond.
    Type: Application
    Filed: February 11, 2009
    Publication date: August 13, 2009
    Inventor: Hiroyuki CHIKU
  • Publication number: 20090181470
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.
    Type: Application
    Filed: November 28, 2008
    Publication date: July 16, 2009
    Inventors: Hiroyuki CHIKU, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Publication number: 20090087927
    Abstract: An object of the present invention is to overcome the problem of nonspecific adsorption of a labeled antibody on the detection site and to provide an immunochromatography method by which the false positive signal can be suppressed, and wherein the detection sensitivity is high and the highly reliable measurement can be performed.
    Type: Application
    Filed: September 26, 2008
    Publication date: April 2, 2009
    Inventor: Hiroyuki CHIKU
  • Publication number: 20090005543
    Abstract: The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 1, 2009
    Applicant: National Inst of Adv Industrial Science and Tech.
    Inventors: Fujio MIZUKAMI, Yoshimichi Kiyozumi, Takuji Ikeda, Akiko Kawai, Takako Nagase, Kengo Sakaguchi, Hiroyuki Chiku
  • Publication number: 20060194279
    Abstract: The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.
    Type: Application
    Filed: July 7, 2004
    Publication date: August 31, 2006
    Inventors: Fujio Mizukami, Yoshimichi Kiyozumi, Takuji Ikeda, Akiko Kawai, Takako Nagase, Kengo Sakaguchi, Hiroyuki Chiku
  • Publication number: 20060034026
    Abstract: An electronic device is composed of a reflector provided so as to cover a plug of a cabinet (sub-rack) into which a plug-in unit is plugged, and reflecting an electromagnetic wave which leaks from the plug; and a cable support supporting a cable connected to the plug-in unit and taken out of the plug, and forming an absorber which absorbs the electromagnetic wave reflected by the reflector.
    Type: Application
    Filed: December 3, 2004
    Publication date: February 16, 2006
    Applicant: FUJITSU LIMITED
    Inventors: Hiroyuki Chiku, Shinji Kajihara, Yutaka Matsukuma, Kazuo Ueno, Akihiro Hamaguchi, Akira Kikuchi