Patents by Inventor Hiroyuki Ebinuma

Hiroyuki Ebinuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8039223
    Abstract: Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: October 18, 2011
    Assignees: Sekisui Medical Co., Ltd., Toudai TLO, Ltd.
    Inventors: Hiroyuki Ebinuma, Hirokazu Yago, Yuka Akimoto, Osamu Miyazaki, Takashi Kadowaki, Toshimasa Yamauchi, Kazuo Hara
  • Publication number: 20110177610
    Abstract: Disclosed is a novel marker for an arteriosclerotic disease. Also disclosed is a method for evaluating the presence or level of an arteriosclerotic disease in a mammal, or a method for evaluating the prophylactic or therapeutic effect on an arteriosclerotic disease in a mammal, which is characterized by detecting a soluble LR11 in a sample collected from the mammal.
    Type: Application
    Filed: June 13, 2008
    Publication date: July 21, 2011
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Masanao Matsuo, Hiroyuki Ebinuma, Isamu Fukamachi, Hideaki Bujo, Yasushi Saito
  • Patent number: 7951553
    Abstract: The present invention provides a convenient, efficient method for assaying glycated protein, fructosyl peptide, or fructosyl amino acid which can be performed with reduced effect of fructosyl lysine compounds. The invention also provides a reagent for the assay. The invention is directed to a method for reducing the effect of a fructosyl lysine compound in an assay of fructosyl peptide or fructosyl amino acid contained in a sample, characterized by including causing an enzyme for assaying fructosyl peptide or fructosyl amino acid to act specifically on fructosyl peptide or fructosyl amino acid at a pH of 4.0 to 7.0 and measuring the product at a pH of 4.0 to 7.0; and a method for assaying glycated protein through the above method.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: May 31, 2011
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Yuriko Taniguchi, Hiroyuki Ebinuma, Kazunori Saito
  • Publication number: 20110091993
    Abstract: Provided is a method for quantifying soluble LR11 in a biological sample such as serum by an immunological means conveniently and accurately without the need of carrying out any complicated separation manipulation. An immunological quantification method for soluble LR11 in a sample derived from a mammal, including a step of treating the sample with at least one surfactant selected from a group consisting of a polyoxyalkylene alkyl ether, a polyoxyalkylene alkyl phenyl ether, an alkyl glycoside, an alkylthio glycoside, an acyl-N-methylglucamide and a salt of cholic acid.
    Type: Application
    Filed: March 17, 2009
    Publication date: April 21, 2011
    Applicant: Sekisui Medical Co., Ltd.
    Inventors: Masanao Matsuo, Hiroyuki Ebinuma, Isamu Fukamachi, Hideaki Bujo, Yasushi Saito
  • Publication number: 20100330600
    Abstract: Provided is a method of separating and measuring highly active HMW adiponectin in adiponectin multimers. A method of measuring high-molecular-weight adiponectin in a sample, wherein adiponectin multimers are separated by use of a protease and measured immunologically, the method comprising reacting a sample containing adiponectin multimers with chymotrypsin.
    Type: Application
    Filed: February 27, 2009
    Publication date: December 30, 2010
    Applicant: Sekisui Medical Co., Ltd.
    Inventor: Hiroyuki Ebinuma
  • Patent number: 7829294
    Abstract: The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an A?-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: November 9, 2010
    Assignee: Daiichi Pure Chemicals Co., Ltd.
    Inventors: Masanao Matsuo, Hiroyuki Ebinuma, Osamu Miyazaki, Kyoko Tanaka, Akiko Suzuki
  • Patent number: 7781171
    Abstract: The invention provides a method of pretreating a sample for conveniently, quickly and accurately measuring the total amount of adiponectin present in a biological sample contaminated with various adiponectin multimers. The method of measuring an sample for immunologically assaying the total amount of adiponectin present in the sample comprises reacting, with an adiponectin-containing sample, at least one of a reducing agent, an acid or a salt thereof, a surfactant, and a protease.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: August 24, 2010
    Assignees: Daiichi Pure Chemicals Co., Ltd., Toudai TLO, Ltd.
    Inventors: Hiroyuki Ebinuma, Hirokazu Yago, Yuka Akimoto, Osamu Miyazaki, Takashi Kadowaki, Toshimasa Yamauchi
  • Publication number: 20090291461
    Abstract: Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 26, 2009
    Applicants: DAIICHI PURE CHEMICALS CO., LTD, TOUDAI TLO, LTD.
    Inventors: Hiroyuki EBINUMA, Hirokazu Yago, Yuka Akimoto, Osamu Miyazaki, Takashi Kadowaki, Toshimasa Yamauchi, Kazuo Hara
  • Patent number: 7608405
    Abstract: Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying of a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: October 27, 2009
    Assignees: Daiichi Pure Chemicals Co., Ltd., Toudai TLO, Ltd.
    Inventors: Hiroyuki Ebinuma, Hirokazu Yago, Yuka Akimoto, Osamu Miyazaki, Takashi Kadowaki, Toshimasa Yamauchi, Kazuo Hara
  • Publication number: 20090096926
    Abstract: In an automatic gain control circuit comprising a black level detecting unit which detects a black level from a video signal, a white level detecting unit which detects a white level from the video signal, and an analog-to-digital converter which adjusts a dynamic range of the video signal based on a difference value between the black level and the white level, a video signal for adjustment including a black level which indicates a minimum brightness of a video image and a white level which indicates a maximum brightness of the video image is input and the dynamic range is adjusted.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Applicants: SANYO ELECTRIC CO., LTD., SANYO SEMICONDUCTOR CO., LTD.
    Inventors: Hirotoshi Mori, Hiroyuki Ebinuma
  • Publication number: 20090096928
    Abstract: There is provided a color killer circuit comprising a burst amplitude detection unit that detects an amplitude of a color burst; a delay unit that stores, delays, by a predetermined period of time, and outputs the detected amplitude; a subtractor that calculates a difference between an output from the burst amplitude detection unit and an output from the delay unit; a first comparator that compares the output from the burst amplitude detection unit with a first threshold value to determine whether or not the output from the burst amplitude detection unit is less than the first threshold value; and a second comparator that compares an output from the subtractor with a second threshold value to determine whether or not the output from the subtractor is greater than the second threshold value, wherein the color killer circuit masks the color component of the composite video signal when the first comparator determines that the output from the burst amplitude detection unit is less than the first threshold value,
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Applicants: SANYO ELECTRIC CO., LTD., SANYO SEMICONDUCTOR CO., LTD.
    Inventors: Chikara Sakyo, Hiroyuki Ebinuma
  • Publication number: 20090096923
    Abstract: A sync separation circuit separates a synchronizing signal from a video signal containing the synchronizing signal. A minimum level detecting section detects a minimum level of a video signal. A sync tip level detecting section detects a sync tip level in the video signal. A pedestal level detecting section detects a pedestal level in the video signal. Based on both the sync tip level detected by the sync tip level detecting section and the pedestal level control by the pedestal level detecting section, a slice level setting section sets a slice level corresponding to an intermediate value between the sync tip level and the pedestal level. The slice level control section sets the slice level based on the minimum level detected by the minimum level detecting section if the slice level set based on the sync tip level and the pedestal level is inappropriate.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 16, 2009
    Applicants: SANYO ELECTRIC CO., LTD., SANYO SEMICONDUCTOR CO., LTD.
    Inventors: Toru Okada, Hiroyuki Ebinuma
  • Patent number: 7456903
    Abstract: A video signal processing circuit is supplied with an analog composite video signal formed by combining at least a luminance signal with a sync signal, and processes the analog composite video signal. The video signal processing circuit has an analog filter which removes high-frequency components from the analog composite video signal, a sync separation circuit which separates a sync signal from an output signal from the analog filter, an AD converter which performs AD conversion on the analog composite video signal, and a digital video signal processing circuit which performs predetermined video signal processing on the composite video signal digitized by the AD converter, by using the sync signal obtained by the sync separation circuit.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: November 25, 2008
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Ikuo Osawa, Yoshifumi Yoshida, Hiroyuki Ebinuma, Toru Okada
  • Publication number: 20080233605
    Abstract: The present invention provides a convenient, efficient method for assaying glycated protein, fructosyl peptide, or fructosyl amino acid which can be performed with reduced effect of fructosyl lysine compounds. The invention also provides a reagent for the assay. The invention is directed to a method for reducing the effect of a fructosyl lysine compound in an assay of fructosyl peptide or fructosyl amino acid contained in a sample, characterized by including causing an enzyme for assaying fructosyl peptide or fructosyl amino acid to act specifically on fructosyl peptide or fructosyl amino acid at a pH of 4.0 to 7.0 and measuring the product at a pH of 4.0 to 7.0; and a method for assaying glycated protein through the above method.
    Type: Application
    Filed: November 18, 2004
    Publication date: September 25, 2008
    Applicant: DAICHI PURE CHEMICALS CO., LTD.
    Inventors: Yuriko Taniguchi, Hiroyuki Ebinuma, Kazunori Saito
  • Patent number: 7407774
    Abstract: A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which has an ability, by the dehydrogenation reaction, to oxidize the specific component or a substance derived from the specific component, and measuring the formed reductant of the electron acceptor, wherein the method avoids the influence of hemoglobin effectively if any contained in the specimen by using a measuring reagent containing albumin, thereby making an quantitative determination of the target component accurately; and a reagent for the quantitative determination.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: August 5, 2008
    Assignee: Sekisui Medical Co., Ltd.
    Inventors: Hiroyuki Ebinuma, Kumiko Yuki
  • Patent number: 7393549
    Abstract: The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: July 1, 2008
    Assignee: Daiichi Pure Chemicals Co., Ltd.
    Inventor: Hiroyuki Ebinuma
  • Patent number: 7329520
    Abstract: The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: February 12, 2008
    Assignee: Daiichi Pure Chemicals Co., Ltd.
    Inventor: Hiroyuki Ebinuma
  • Publication number: 20080009077
    Abstract: The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an A?-chain of the soluble fibrin formed through thrombin digestion of fibrinogen. The present invention is also directed to a hybridoma which produces the antibody, an immunological assay method employing the antibody, and a method for evaluating hypercoagulability in a test sample by measuring the soluble fibrin level in the sample with the assay method. Through employment of the monoclonal antibody of the present invention, soluble fibrin on which plasmin has not acted, which reflects exclusively initial hypercoagulability, can be specifically detected.
    Type: Application
    Filed: December 27, 2005
    Publication date: January 10, 2008
    Applicant: Daiichi Pure Chemicals Co., Ltd.
    Inventors: Masanao Matsuo, Hiroyuki Ebinuma, Osamu Miyazaki, Kyoko Tanaka, Akiko Suzuki
  • Patent number: 7244620
    Abstract: The present invention provides a method for quantitatively determining a reducing substance, which comprises reacting a reducing substance in a test specimen with iron (III) ions, reacting iron (II) ions formed by reduction of the iron (III) ions or residual iron (III) ions with a metal indicator which is capable of reacting specifically with the iron (II) ions or the residual iron (III) ions to undergo color development, and carrying out quantitative determination by measuring the degree of color development, wherein a chelating agent which is specific to copper ions is added to the test specimen before the reaction of the reducing substance with the iron (III) ions; and a reagent used for it.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: July 17, 2007
    Assignee: Daiichi Pure Chemicals Co., Ltd.
    Inventors: Masahiro Sekiguchi, Takuji Matsumoto, Hiroyuki Ebinuma
  • Publication number: 20070154879
    Abstract: A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which has an ability, by the dehydrogenation reaction, to oxidize the specific component or a substance derived from the specific component, and measuring the formed reductant of the electron acceptor, wherein the method avoids the influence of hemoglobin effectively if any contained in the specimen by using a measuring reagent containing albumin, thereby making an quantitative determination of the target component accurately; and a reagent for the quantitative determination.
    Type: Application
    Filed: March 12, 2007
    Publication date: July 5, 2007
    Applicant: DAIICHI PURE CHEMICALS CO., LTD.
    Inventors: Hiroyuki Ebinuma, Kumiko Yuki