Abstract: The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

Abstract: A controller for a vehicle equipped with a motor for running includes one or more processors and one or more recording media storing a program to be executed by the one or more processors. The program includes one or more instructions configured to cause the one or more processors to perform a sweep driving process including sweeping an excitation frequency of vibration applied to a vehicle body of the vehicle by the motor while driving the motor during an inspection of the vehicle.

Abstract: Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

Abstract: The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.

Abstract: Voltage detection line includes conductive wire, and tab terminal that electrically connects bus bar electrically connected to output terminal of the battery and conductive wire. Support plate includes base plate on which voltage detection line is placed, and position restricting structure of tab terminal. Position restricting structure includes receiving surface part against which tab terminal abuts, and biasing part that pushes tab terminal toward receiving surface part.

Abstract: A robot controller acquires positions and orientations of a terminal apparatus in a physical space. The robot controller generates trajectory information indicating a trajectory of an end effector of the robot, the end effector moving to the same positions in the physical space at which the terminal apparatus was positioned, by defining positions and orientations of the end effector based on the acquired positions and orientations of the terminal apparatus.

Abstract: Provided are a high-frequency power supply device and an output control method therefor which are capable of constantly keeping the phase of the outputted high-frequency pulse uniform even in a structure in which the synchronizing pulse and the clock pulse are generated separately.

Abstract: A resonance sound signal generation method includes providing an instruction configured to generate a sound signal corresponding to a received pitch and producing a resonance sound signal. The method also includes receiving a multiple damper operation with respect to a plurality of pitches in a first pitch range. The method also includes providing an instruction configured to produce the resonance sound signal based on an additional sound relating to the multiple damper operation when the multiple damper operation is received.

Abstract: [Problem] Provided is an airtight terminal that is configured to lessen distortion-borne stress caused in a metallic outer ring as a result of screw fastening or other fixing means to prevent the stress from readily propagating to an insulating material in a sealed place of a lead. [Solution] An airtight terminal is provided that includes a metallic outer ring 13 having through holes 11 formed for screw fastening and sealing holes 12, leads 14 inserted through the sealing holes 12 in the metallic outer ring 13, and pieces of an insulating material 15 to seal gaps between the metallic outer ring 13 and the respective leads 14. The metallic outer ring 13 is provided with pairs of cavities 13a and steps 13b surrounding the respective sealing holes 12.

Abstract: A high-frequency power supply device, which outputs high-frequency pulses to a target device on the basis of a synchronous pulse and a clock pulse, and the output control method therefor are such that a period reference signal is generated from output timing information pertaining to the synchronous pulse, an output level signal is generated from output level information, an output stop time is timed on the basis of the period reference signal and an output stop signal is generated, and, when the period reference signal, the output level signal, and the clock pulse are received and a high-frequency pulse is formed on the basis of these signals, transmission of the output level signal is stopped while the output stop signal is being received.

Abstract: To provide a stabilized preparation for using Araliadiol as a medicine or a functional food, and a method for manufacturing the same. A powdery preparation that contains Araliadiol, dextrin and cyclodextrin. Preferably, the powdery preparation further contains a macromolecular polysaccharide.

Abstract: An imaging apparatus includes: an imaging sensor that captures an object image formed through an interchangeable lens to generate image data; a driver that performs image blur correction by moving the imaging sensor in a plane perpendicular to an optical axis; and a controller that causes the driver to move the imaging sensor. The controller causes the driver to move the imaging sensor automatically, thereby detecting a movable amount of the imaging sensor that does not cause a vignetting in the captured image at a time when moving the imaging sensor for image blur correction, and causes the driver to move the imaging sensor within a range of the detected movable amount.

Abstract: A pulsed high frequency monitor of the present invention monitors the power level of a pulsed high frequency on the basis of a transition pattern in which the power level changes in time series instead of monitoring the power level by comparing the power level of the pulsed high frequency with a threshold value. The pulsed high frequency monitor comprises: a DC circuit that converts the pulsed high frequency into DC and outputs the power level; a power level change detection circuit that detects a level change of the power level; and a transition pattern determination circuit that determines a time-series transition pattern of the power level on the basis of the level change detected by the power level change detection circuit.

Abstract: Provided is a pharmaceutical composition that can be easily administered into the ear and has a function of allowing a drug to be retained and slowly released in the ear, a pharmaceutical composition for otic administration comprising one, or two or more drugs and a water-dispersible fine cellulose composition, in particular, microcrystalline cellulose-carmellose sodium.

Abstract: Provided is a pharmaceutical composition that can be administered into the ear without any complicated operation and has a function of allowing a drug to be retained and slowly released in the ear. A pharmaceutical composition for otic administration, comprising one, or two or more drugs and a polymer, wherein when the complex viscosity of the pharmaceutical composition is measured using a rheometer under the conditions of a shear strain of 5% and an angular frequency of 50 rad/sec., while increasing the temperature from 25° C. to 37° C. at a heating rate of 1° C./10 sec., the complex viscosity is less than 1,650 mPa·s at 25° C., and is from 1,650 mPa·s to 100,000 mPa·s at 10 minutes after reaching 37° C.

Abstract: Provided are a high-frequency power supply device and an output control method therefor which are capable of constantly keeping the phase of the outputted high-frequency pulse uniform even in a structure in which the synchronizing pulse and the clock pulse are generated separately.

Abstract: A high-frequency power supply device, which outputs high-frequency pulses to a target device on the basis of a synchronous pulse and a clock pulse, and the output control method therefor are such that a period reference signal is generated from output timing information pertaining to the synchronous pulse, an output level signal is generated from output level information, an output stop time is timed on the basis of the period reference signal and an output stop signal is generated, and, when the period reference signal, the output level signal, and the clock pulse are received and a high-frequency pulse is formed on the basis of these signals, transmission of the output level signal is stopped while the output stop signal is being received.

Abstract: A shift drum angle detecting device includes: a first angle sensor configured to output a first sensor output value corresponding to a shaft rotational angle of a first sensor shaft integrally rotating with a shift drum; and a second angle sensor configured to output a second sensor output value corresponding to a shaft rotational angle of a second sensor shaft rotating at an increased speed as a result of a speed increasing mechanism increasing the rotation of the first sensor shaft. A first sensor switching angle where the maximum value and the minimum value of the first sensor output value are switched and a second sensor switching angle where the maximum value and the minimum value of the second sensor output value are switched are set to be different from each other in rotational angle of the shift drum. Such device precisely detects any rotational angle of the shift drum.

Abstract: Provided is a composition useful for preventing and/or treating neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The composition is for preventing and/or treating a neurodegenerative disorder, and contains, as an active ingredient, a compound represented by the following formula (I): or an isomer thereof, or a salt thereof.

Abstract: [Problem] Provided is an airtight terminal that is configured to lessen distortion-borne stress caused in a metallic outer ring as a result of screw fastening or other fixing means to prevent the stress from readily propagating to an insulating material in a sealed place of a lead. [Solution] An airtight terminal is provided that includes a metallic outer ring 13 having through holes 11 formed for screw fastening and sealing holes 12, leads 14 inserted through the sealing holes 12 in the metallic outer ring 13, and pieces of an insulating, material 15 to seal gaps between the metallic outer ring 13 and the respective leads 14. The metallic outer ring 13 is provided with pairs of cavities 13a and steps 13b surrounding the respective sealing holes 12.