Patents by Inventor Hiroyuki Osada

Hiroyuki Osada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200255797
    Abstract: This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Ar1 represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar2 represents phenyl substituted with halogen; R1 and R2 each represent hydrogen, alkyl, cyano, or carboxyl; R1 and R2 may together form oxo; R3 to R10 each represent hydrogen or methyl; and R3 and R4, R5 and R6, R7 and R8, and/or R9 and R10 may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.
    Type: Application
    Filed: April 28, 2020
    Publication date: August 13, 2020
    Applicant: RIKEN
    Inventors: Takeshi Nakano, Tadao ASAMI, Ayumi YAMAGAMI, Hiroyuki OSADA, Misato OHTANI, Taku DEMURA
  • Patent number: 10676711
    Abstract: This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Ar1 represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar2 represents phenyl substituted with halogen; R1 and R2 each represent hydrogen, alkyl, cyano, or carboxyl; R1 and R2 may together form oxo; R3 to R10 each represent hydrogen or methyl; and R3 and R4, R5 and R6, R7 and R8, and/or R9 and R10 may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: June 9, 2020
    Assignee: Riken
    Inventors: Takeshi Nakano, Tadao Asami, Ayumi Yamagami, Hiroyuki Osada, Misato Ohtani, Taku Demura
  • Patent number: 10435394
    Abstract: The present invention concerns: a plant growth-promoting agent comprising a compound represented by Formula (I) or a salt thereof: wherein Ar1 represents a substituted or unsubstituted phenyl group, NZ represents a nitrogen-containing heterocyclic ring group or an acyclic nitrogen-containing group having a partial structure of the nitrogen-containing heterocyclic ring group, n is 0, 1, or 2, R1 and R2 each represent a hydrogen atom, a substituted or unsubstituted C1-3-alkyl group, a cyano group, or a carboxyl group, R1 and R2 may together form an oxo group, and when n is 2, R1 or R2 may be the same or different; and a method for promoting plant growth using the plant growth-promoting agent.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: October 8, 2019
    Assignee: Riken
    Inventors: Takeshi Nakano, Tadao Asami, Hiroyuki Osada
  • Patent number: 10323254
    Abstract: According to the present invention, a transgenic plant, wherein expression of the BSS1 gene having activity to bind to a BIL1 protein to inhibit the transfer of the BIL1 protein into the nucleus so as to down-regulate brassinosteroid signaling is suppressed or promoted, and a method for regulating plant growth, wherein expression of the BSS1 gene in a plant body is suppressed or promoted, are provided.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: June 18, 2019
    Assignee: RIKEN
    Inventors: Takeshi Nakano, Tadao Asami, Ayumi Yamagami, Hiroyuki Osada
  • Patent number: 10292976
    Abstract: The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 21, 2019
    Assignee: RIKEN
    Inventors: Akira Wada, Hiroki Hayase, Nobumoto Watanabe, Hiroyuki Osada, Takeshi Shimizu, Konstanty Wierzba
  • Publication number: 20190054074
    Abstract: The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Application
    Filed: October 23, 2018
    Publication date: February 21, 2019
    Applicant: RIKEN
    Inventors: Akira WADA, Hiroki HAYASE, Nobumoto WATANABE, Hiroyuki OSADA, Takeshi SHIMIZU, Konstanty WIERZBA
  • Patent number: 10137119
    Abstract: The invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 27, 2018
    Assignee: RIKEN
    Inventors: Akira Wada, Hiroki Hayase, Nobumoto Watanabe, Hiroyuki Osada, Takeshi Shimizu, Konstanty Wierzba
  • Publication number: 20180161288
    Abstract: A tau aggregation inhibitor reduces tau aggregation in cells. The tau aggregation inhibitor can include a catechol structure-containing compound or a salt thereof, and the catechol structure-containing compound can be one of isoprenaline, dopamine, dobutamine, levodopa, levodopa/carbidopa, trimetoquinol, hexoprenaline, methyldopa, and droxidopa. One example of the catechol structure-containing compound is isoprenaline, which can be d-enantiomer of isoprenaline or d/l-racemic mixture of isoprenaline. Tauopathies to be prevented or treated by the inhibitor include AD, Down's syndrome, Pick's disease, corticobasal degeneration, and progressive supranuclear palsy.
    Type: Application
    Filed: February 12, 2018
    Publication date: June 14, 2018
    Inventors: Akihiko TAKASHIMA, Yoshiyuki SOEDA, Hiroyuki OSADA, Yasuo IHARA, Tomohiro MIYASAKA, Hachiro SUGIMOTO
  • Publication number: 20180104226
    Abstract: The invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 19, 2018
    Applicant: RIKEN
    Inventors: Akira WADA, Hiroki HAYASE, Nobumoto WATANABE, Hiroyuki OSADA, Takeshi SHIMIZU, Konstanty WIERZBA
  • Publication number: 20180030468
    Abstract: An object of the present invention is to elucidate the mechanism of plant growth regulation by brassinosteroid and the mechanism of transfer of the BIL1 protein that is the master transcription factor of brassinosteroid signaling into the nucleus, discover new factors involved in the mechanisms, and using the factors for plant growth regulation, thereby increasing production of plant biomass or crop. According to the present invention, a transgenic plant, wherein expression of the BSS1 gene having activity to bind to a BIL1 protein to inhibit the transfer of the BIL1 protein into the nucleus so as to down-regulate brassinosteroid signaling is suppressed or promoted, and a method for regulating plant growth, wherein expression of the BSS1 gene in a plant body is suppressed or promoted, are provided.
    Type: Application
    Filed: January 25, 2016
    Publication date: February 1, 2018
    Applicant: RIKEN
    Inventors: Takeshi NAKANO, Tadao ASAMI, Ayumi YAMAGAMI, Hiroyuki OSADA
  • Patent number: 9863936
    Abstract: Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5?-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5?-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an RNA corresponding to the above-mentioned nucleic acid construct.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: January 9, 2018
    Assignee: RIKEN
    Inventors: Akira Wada, Hiroyuki Osada
  • Patent number: 9861626
    Abstract: The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 9, 2018
    Assignee: RIKEN
    Inventors: Akira Wada, Hiroki Hayase, Nobumoto Watanabe, Hiroyuki Osada, Takeshi Shimizu, Konstanty Wierzba
  • Patent number: 9812263
    Abstract: Disclosed is a novel compound represented by formula (1) below.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: November 7, 2017
    Assignee: ADEKA CORPORATION
    Inventors: Minoru Hanaya, Kenji Kakiage, Masafumi Unno, Yohei Aoyama, Toru Yano, Daisuke Sawamoto, Hiroyuki Osada
  • Publication number: 20170305886
    Abstract: The present invention concerns: a plant growth-promoting agent comprising a compound represented by Formula (I) or a salt thereof: wherein Ar1 represents a substituted or unsubstituted phenyl group, NZ represents a nitrogen-containing heterocyclic ring group or an acyclic nitrogen-containing group having a partial structure of the nitrogen-containing heterocyclic ring group, n is 0, 1, or 2, R1 and R2 each represent a hydrogen atom, a substituted or unsubstituted C1-3-alkyl group, a cyano group, or a carboxyl group, R1 and R2 may together form an oxo group, and when n is 2, R1 or R2 may be the same or different; and a method for promoting plant growth using the plant growth-promoting agent.
    Type: Application
    Filed: October 7, 2015
    Publication date: October 26, 2017
    Applicant: RIKEN
    Inventors: Takeshi Nakano, Tadao ASAMI, Hiroyuki OSADA
  • Patent number: 9630953
    Abstract: The present invention provides a small compound targeting at TACC3. The present invention further provides a drug, particularly, an anticancer agent, comprising the small compound targeting at TACC3. A compound represented by the general formula (I) or a pharmaceutically acceptable salt, solvate, or ester derivative thereof binds to TACC3 and inhibits cell growth. Thus, these compounds can be used as drugs, particularly, anticancer agents.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: April 25, 2017
    Assignee: JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Ryoji Yao, Hiroyuki Osada, Yasumitsu Kondoh
  • Publication number: 20170105414
    Abstract: This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Ar1 represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar2 represents phenyl substituted with halogen; R1 and R2 each represent hydrogen, alkyl, cyano, or carboxyl; R1 and R2 may together form oxo; R3 to R10 each represent hydrogen or methyl; and R3 and R4, R5 and R6, R7 and R8, and/or R9 and R10 may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.
    Type: Application
    Filed: May 28, 2015
    Publication date: April 20, 2017
    Applicant: RIKEN
    Inventors: Takeshi Nakano, Tadao ASAMI, Ayumi YAMAGAMI, Hiroyuki OSADA, Misato OHTANI, Taku DEMURA
  • Patent number: 9530571
    Abstract: A novel compound represented by general formula (1), a support supporting this novel compound, and a photoelectric transduction element using this support. (In the formula, Y is an optionally substituted hydrocarbon group having 1-20 carbon atoms having —CO—NR4- or —SO2—NR4- in the group; Z is a group of a conjugated system; R1, R2, and R3 represent optionally substituted hydrocarbon groups or optionally substituted hydrocarbon-oxy groups; at least one of R1, R2, and R3 is an optionally substituted hydrocarbon-oxy group; R4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1-20 carbon atoms; R4 and Z may join together to form a ring. However, Y excludes groups represented by partial structural formulas (Y-11) and (Y-12).
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: December 27, 2016
    Assignee: ADEKA CORPORATION
    Inventors: Yohei Aoyama, Kazuyuki Noda, Hiroyuki Osada
  • Patent number: 9496095
    Abstract: A novel compound represented by general formula (1), a carrier system including a carrier having the novel compound fixed thereon, and a photoelectric conversion device having the carrier system. In formula (1), Z is a C1-C50 conjugated group; R1 is a C6-C20 aromatic hydrocarbon group, a C7-C20 aromatic hydrocarbon group substituted by an aliphatic hydrocarbon group, or a C1-C20 aliphatic hydrocarbon group, each substituted by carboxyl, cyano, amino, amide, or nitro, the aliphatic hydrocarbon group being optionally interrupted by —O—, etc.; R2 is hydrogen or an optionally substituted C1-C20 hydrocarbon group; R30, R31, R32, R33, R40, R41, R42, R43, and R44 are each hydrogen or optionally substituted hydrocarbon group, and adjacent two of them may be connected to form a ring; R5 is hydrogen or cyano; and R11 is represented by formula (11-1) or (11-2), wherein n, ring A, and the like are as defined in the description.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: November 15, 2016
    Assignee: ADEKA CORPORATION
    Inventors: Hiroyuki Osada, Yohei Aoyama
  • Publication number: 20160324847
    Abstract: The present invention aims to prevent and/or treat malaria using an antimalarial drug comprising, as an active ingredient, a metal chelator represented by the following formula (I), (III), (IV), (V), (VI), or (VII), such as tris(2-pyridylmethyl)amine.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 10, 2016
    Inventors: Akira WADA, Hiroki HAYASE, Nobumoto WATANABE, Hiroyuki OSADA, Takeshi SHIMIZU, Konstanty WIERZBA
  • Publication number: 20160211085
    Abstract: Disclosed is a novel compound represented by formula (1) below. In the formula, A represents an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic group, B represents a group including a chain of one to four pieces of one or more groups selected from groups represented by specific formulae (B-1) to (B-13) (such as —C?C— or —N?N—, specifically see the description), R1 to R3 each represent an optionally substituted hydrocarbon or hydrocarbonoxy group, at least one of R1 to R3 represents an optionally substituted hydrocarbonoxy group, R4 and R5 each represent an optionally substituted hydrocarbon group, R4 and R5 may be linked together to form a ring, and R4 and R5 may be each independently linked with A to form a ring.
    Type: Application
    Filed: March 25, 2016
    Publication date: July 21, 2016
    Inventors: Minoru HANAYA, Kenji KAKIAGE, Masafumi UNNO, Yohei AOYAMA, Toru YANO, Daisuke SAWAMOTO, Hiroyuki OSADA