Patents by Inventor Hisashi Iwaasa

Hisashi Iwaasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7696339
    Abstract: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: April 13, 2010
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hideki Sano, Hisashi Iwaasa, Satoshi Mashiko
  • Publication number: 20090176243
    Abstract: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.
    Type: Application
    Filed: June 26, 2008
    Publication date: July 9, 2009
    Inventors: Hideki Sano, Hisashi Iwaasa, Satoshi Mashiko
  • Patent number: 7541477
    Abstract: This invention relates to a benzimidazole derivative of the general formula [I] [wherein B1, B2, and B3 represent hydrogen atom or lower alkyl; R1 and R2 are same or different and represent lower alkyl, etc.; R3 and R4 represent hydrogen atom, etc.; W represents a 3 to 8-membered aromatic or alphatic heterocycle, etc.; and Ar represents a substituted or unsubstituted aromatic heterocycle, etc.] This compound functions as an antagonist to melanin-concentrating hormone receptor and is useful as a drug for central diseases, circulatory diseases and metabolic diseases.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: June 2, 2009
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Minoru Moriya, Akio Kanatani, Hisashi Iwaasa, Akane Ishihara, Takehiro Fukami
  • Patent number: 7531668
    Abstract: A compound represented by the formula [I]: [wherein R1 and R2 are the same or different and each represents C1-6 alkyl, C3-8 cycloalkyl, et al; R3a, R3b, and R4 are the same or different and each represents hydrogen, C1-6 alkyl, et al; X represents —N—, —CH—, et al; Y1 represents a single bond, C1-3 alkylene, et al; Y2 represents C1-4 alkylene, oxy(C1-4 alkylene), et al; Ar1 represents a monocyclic aromatic carbocyclic group, monocyclic aromatic heterocyclic group, et al; and Ar2 represents a 5- or 6-membered aromatic carbocyclic group, aromatic heterocyclic group, et al]. This compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, et al.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: May 12, 2009
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Takao Suzuki, Minoru Moriya, Shunji Sakuraba, Sayaka Mizutani, Hisashi Iwaasa, Akio Kanatani
  • Patent number: 7485647
    Abstract: This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: February 3, 2009
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Minoru Moriya, Takao Suzuki, Akane Ishihara, Hisashi Iwaasa, Akio Kanatani
  • Patent number: 7422898
    Abstract: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: September 9, 2008
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hideki Sano, Hisashi Iwaasa, Satoshi Mashiko
  • Publication number: 20080118436
    Abstract: An object of the present invention is to provide a pathologic model animal more accurately reflecting the pathologic conditions of nonalcoholic steatohepatitis patients, and the present invention provides the pathologic model animal for nonalcoholic steatohepatitis produced by continuously administering a tetracycline antibiotic to an animal having its body weight significantly increased compared with that of a group fed with a normal diet by feeding it with a high-fat diet.
    Type: Application
    Filed: September 13, 2005
    Publication date: May 22, 2008
    Inventors: Jun Suzuki, Hisashi Iwaasa, Minoru Sasaki, Makoto Ito, Akio Kanatani
  • Publication number: 20080009016
    Abstract: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the sequences listed as SEQ ID NOS: 1 to 4 provide non-human primate or rat GPR103 genes and proteins and information based on the genes and proteins. The genes and proteins can be used for evaluation of compounds. The nucleic acids or proteins having the sequence listed as SEQ ID NO: 5 or 6 provide a GPR103 ligand.
    Type: Application
    Filed: April 14, 2005
    Publication date: January 10, 2008
    Inventors: Hideki Sano, Hisashi Iwaasa, Satoshi Mashiko
  • Publication number: 20070299070
    Abstract: A compound represented by the formula [I]: [wherein R1 and R2 are the same or different and each represents C1-6 alkyl, C3-8 cycloalkyl, et al; R3a, R3b, and R4 are the same or different and each represents hydrogen, C1-6 alkyl, et al; X represents —N—, —CH—, et al; Y, represents a single bond, C1-3 alkylene, et al; Y2 represents C1-4 alkylene, oxy(C1-4 alkylene), et al; Ar1 represents a monocyclic aromatic carbocyclic group, monocyclic aromatic heterocyclic group, et al; and Ar2 represents a 5- or 6-membered aromatic carbocyclic group, aromatic heterocyclic group, et al]. This compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, et al.
    Type: Application
    Filed: September 30, 2005
    Publication date: December 27, 2007
    Inventors: Takao Suzuki, Minoru Moriya, Shunji Sakuraba, Sayaka Mizutani, Hisashi Iwaasa, Akio Kanatani
  • Publication number: 20070083037
    Abstract: It is intended to provide a nucleic acid represented by SEQ ID NO: 1 or 3; a protein represented by SEQ ID NO: 2 or 4; a recombinant vector containing a gene which comprises the above-described nucleic acid; a nonhuman primate NPY Y4 gene obtained by using a transformed cell containing the above-described recombinant vector; and so on. Moreover, it becomes possible to evaluate or screen a compound acting on the NPY Y4 receptor.
    Type: Application
    Filed: November 1, 2004
    Publication date: April 12, 2007
    Inventors: Hideki Sano, Hisashi Iwaasa
  • Publication number: 20060287340
    Abstract: This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.
    Type: Application
    Filed: May 20, 2004
    Publication date: December 21, 2006
    Inventors: Minoru Moriya, Takao Suzuki, Akane Ishihara, Hisashi Iwaasa, Akio Kanatani
  • Publication number: 20050222161
    Abstract: This invention relates to a benzimidazole derivative of the general formula [I] [wherein B1, B2, and B3 represent hydrogen atom or lower alkyl; R1 and R2 are same or different and represent lower alkyl, etc.; R3 and R4 represent hydrogen atom, etc.; W represents a 3 to 8-membered aromatic or alphatic heterocycle, etc.; and Ar represents a substituted or unsubstituted aromatic heterocycle, etc.] This compound functions as an antagonist to melanin-concentrating hormone receptor and is useful as a drug for central diseases, circulatory diseases and metabolic diseases.
    Type: Application
    Filed: July 29, 2003
    Publication date: October 6, 2005
    Applicant: BANYU PHARMACEUTICAL CO., LTD
    Inventors: Minoru Moriya, Akio Kanatani, Hisashi Iwaasa, Akane Ishihara, Takehiro Fukami
  • Patent number: 6838465
    Abstract: This invention relates to novel compounds represented by the general formula [I]: (wherein, R1 and R4 are the same or different, and represent hydrogen atoms, lower alkyl groups or the like; R2 and R3 are the same or different, and represent lower alkoxy groups or lower alkyl groups; R5 represents a lower alkyl group or aralkyl group optionally having substituent(s); R6 represents a hydrogen atom or a lower alkyl group; X represents O, S or NH; m represents an integer of 0 to 3; n represents an integer of 0 or 1; and Ar represents a phenyl group or heteroaryl group optionally having substituent(s)). The compounds of the invention have an antagonistic action on orexin receptors, and are useful for treatment of appetite abnormality, obesity, sleeping disorder or the like.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: January 4, 2005
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Koji Yamada, Masaaki Hirose, Hisashi Iwaasa
  • Publication number: 20040044031
    Abstract: This invention relates to novel compounds represented by the general formula [I] 1
    Type: Application
    Filed: January 9, 2003
    Publication date: March 4, 2004
    Inventors: Koji Yamada, Masaaki Hirose, Hisashi Iwaasa