Patents by Inventor Hisayuki Uneyama
Hisayuki Uneyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8747939Abstract: The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 ?m and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.Type: GrantFiled: April 24, 2013Date of Patent: June 10, 2014Assignee: Ajinomoto Co., Inc.Inventors: Itaru Kon, Naoki Hayashi, Tatsuro Tanaka, Hisayuki Uneyama, Shinji Somekawa
-
Patent number: 8652563Abstract: The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 ?m and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.Type: GrantFiled: February 27, 2008Date of Patent: February 18, 2014Assignee: Ajinomoto Co., Inc.Inventors: Itaru Kon, Naoki Hayashi, Tatsuro Tanaka, Hisayuki Uneyama, Shinji Somekawa
-
Publication number: 20130243933Abstract: The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 ?m and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.Type: ApplicationFiled: April 24, 2013Publication date: September 19, 2013Applicant: AJINOMOTO CO., INC.Inventors: Itaru Kon, Naoki Hayashi, Tatsuro Tanaka, Hisayuki Uneyama, Shinji Somekawa
-
Patent number: 7993668Abstract: As a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which improve lower gastrointestinal function and are effective for the prophylaxis or improvement of diarrhea, gastroesophageal reflux or misswallowing caused by administration of a liquid nutritional supplement, the present invention provides a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which comprise at least one kind selected from glutamic acid, 5?-nucleotide and a salt thereof, wherein, when glutamic acid alone is contained, the content thereof on administration is 0.0013-1.3 w/v % as free glutamic acid.Type: GrantFiled: December 28, 2006Date of Patent: August 9, 2011Assignee: Ajinomoto Co., Inc.Inventors: Tatsuro Tanaka, Hisayuki Uneyama, Kunio Torii, Kiyoshi Miwa
-
Publication number: 20110136909Abstract: Agents for the inhibition, suppression, or prevention of overeating include glutamic acid and/or at least one of its salts, as is or in a carrier or base, and have superior safety at a low price and further have a favorable flavor and are suited for long-term use. Such agents will amplify or sustain a sense of fullness and, further, are effective against appetite stimulation that arises regardless of a sense of fullness with respect to foods that are, for example, sweet or delicious, especially for a person who has a drive for thinness.Type: ApplicationFiled: December 20, 2010Publication date: June 9, 2011Inventors: Toshifumi Imada, Shuzhen Hao, Tatsuro Tanaka, Miki Tomoe, Eiichiro Kimura, Hisayuki Uneyama, Kunio Torii
-
Publication number: 20110071075Abstract: A substance is described which can prevent or treat a disease associated with the secretion of an acid. A calcium receptor activator is the active ingredient in a composition which promotes bicarbonate secretion in a gastrointestinal tract. Examples of the calcium receptor activator include ?-Glu-X-Gly, wherein X represents an amino acid or an amino acid derivative, ?-Glu-Val-Y, wherein Y represents an amino acid or an amino acid derivative, ?-Glu-Ala, ?-Glu-Gly, ?-Glu-Cys, ?-Glu-Met, ?-Glu-Thr, ?-Glu-Val, ?-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, ?-Glu-Met(O), ?-Glu-?-Glu-Val, ?-Glu-Val-NH2, ?-Glu-Val-ol, ?-Glu-Ser, ?-Glu-Tau, ?-Glu-Cys(S-Me)(O), ?-Glu-Leu, ?-Glu-Ile, ?-Glu-t-Leu, and ?-Glu-Cys(S-Me).Type: ApplicationFiled: September 23, 2010Publication date: March 24, 2011Inventors: Koji Takeuchi, Eitaro Aihara, Eiji Nakamura, Tetsuo Yano, Mai Hasumura, Hisayuki Uneyama
-
Publication number: 20090291910Abstract: The present invention provides an agent and a food for the prophylaxis or improvement of a functional gastrointestinal disorder, which contains, as an active ingredient, at least one kind selected from glutamic acid, 5?-nucleotide and a salt thereof.Type: ApplicationFiled: May 22, 2009Publication date: November 26, 2009Applicant: AJINOMOTO CO., INCInventors: Hisayuki Uneyama, Tatsuro Tanaka, Kunio Torii, Shinichi Fujita
-
Publication number: 20090018161Abstract: The present invention provides a more effective gastrointestinal function promoter. The present invention also provides a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like. The present invention also provides a method for screening for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like by administering a T1R agonist. The present invention also provides a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.Type: ApplicationFiled: May 2, 2008Publication date: January 15, 2009Applicant: AJINOMOTO CO. INC.Inventors: Tatsuro Tanaka, Hisayuki Uneyama, Shinichi Fujita, Saori Ogawa, Yusuke Amino, Seiji Shiraishi, Koichi Fujita, Tatsuhiro Yamada, Takashi Yamamoto, Takeshi Aihara, Manabu Suzuki
-
Publication number: 20080160137Abstract: The present invention relates to a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that the volume-based median size (d50) of particles in the nutrient composition is 5 to 100 ?m and water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition, or a nutrient composition which contains at least a carbohydrate, a lipid, a protein, and a mineral, and is liquid or semisolid, characterized in that water-insoluble particles having a protein insolubilized by a divalent cation are contained as a major component of the nutrient composition and the mass of the protein with respect to the total moles of divalent ions forming the water-insoluble particles is 1.5 to 3 g/mmol.Type: ApplicationFiled: February 27, 2008Publication date: July 3, 2008Applicant: AJINOMOTO CO. INC.Inventors: Itaru KON, Naoki HAYASHI, Tatsuro TANAKA, Hisayuki UNEYAMA, Shinji SOMEKAWA
-
Publication number: 20080095826Abstract: The present invention provides a method of increasing the lymphocyte count in peripheral blood and a method for stimulating the immune system in a subject, which include administering an effective amount of glutamic acid or a salt thereof to the subject. Since glutamic acid or a salt thereof is not toxic and is free of side effects, it is safe, can be presented in the form of food, and is suitable for application to the elderly and subjects with reduced resistance. Since immunity is enhanced, general conditions can be improved and the mind and body can be activated.Type: ApplicationFiled: September 25, 2007Publication date: April 24, 2008Inventors: Hisayuki Uneyama, Miki Tomoe, Misako Kawai, Naoki Hayashi
-
Publication number: 20070249717Abstract: The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.Type: ApplicationFiled: April 26, 2007Publication date: October 25, 2007Applicant: AJINOMOTO CO. INCInventors: Tetsuo Yano, Masaki Hashimoto, Smriga Miroslav, Hisayuki Uneyama, Kunio Torii
-
Publication number: 20070218112Abstract: The present invention provides an agent and a food for the prophylaxis or improvement of a functional gastrointestinal disorder, which contains, as an active ingredient, at least one kind selected from glutamic acid, 5?-nucleotide and a salt thereof.Type: ApplicationFiled: March 19, 2007Publication date: September 20, 2007Applicant: AJINOMOTO CO., INC.Inventors: Hisayuki Uneyama, Tatsuro Tanaka, Kunio Torii, Shinichi Fujita
-
Publication number: 20070218109Abstract: As a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which improve lower gastrointestinal function and are effective for the prophylaxis or improvement of diarrhea, gastroesophageal reflux or misswallowing caused by administration of a liquid nutritional supplement, the present invention provides a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which comprise at least one kind selected from glutamic acid, 5?-nucleotide and a salt thereof, wherein, when glutamic acid alone is contained, the content thereof on administration is 0.0013-1.3 w/v % as free glutamic acid.Type: ApplicationFiled: December 28, 2006Publication date: September 20, 2007Applicant: AJINOMOTO CO. INCInventors: Tatsuro Tanaka, Hisayuki Uneyama, Kunio Torii, Kiyoshi Miwa
-
Patent number: 7271257Abstract: An isolated DNA molecule which encodes a novel glutamate receptor and a transformed cell expressing the receptor are provided.Type: GrantFiled: August 20, 2004Date of Patent: September 18, 2007Assignee: Ajinomoto Co., Inc.Inventors: Ana San Gabriel, Hisayuki Uneyama, Takami Maekawa, Kunio Torii
-
Publication number: 20070098777Abstract: Melatonin has an activity of treating or preventing brain edema. Thus, the invention relates to a pharmaceutical composition comprising melatonin as an active ingredient. And, the invention relates to use of melatonin in the preparation of a pharmaceutical composition comprising melatonin as an active ingredient.Type: ApplicationFiled: November 22, 2006Publication date: May 3, 2007Applicant: AJINOMOTO CO., INC.Inventors: Hitoo NISHINO, Kunio Torii, Hisayuki Uneyama
-
Patent number: 7186819Abstract: The inventive subject matter relates to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method for identifying an agonist for glutamic acid, an antibody to the receptor, and processes for making glutamate receptor modulators and pharmaceutical compositions comprising said modulator.Type: GrantFiled: December 10, 2004Date of Patent: March 6, 2007Assignee: Ajinomoto Co., Inc.Inventors: Ana San Gabriel, Hisayuki Uneyama, Takami Maekawa, Kunio Torii
-
Patent number: 7157250Abstract: An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction: (A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or (B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein.Type: GrantFiled: April 21, 2004Date of Patent: January 2, 2007Assignee: Ajinomoto Co., Inc.Inventors: Ana San Gabriel, Takami Maekawa, Hisayuki Uneyama, Kunio Torii
-
Publication number: 20060040350Abstract: The inventive subject matter relates to novel glutamate receptors and utilization thereof; more specifically to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method for identifying an agonist for glutamic acid, an antibody to the receptor, and processes for making glutamate receptor modulators and pharmaceutical compositions comprising said modulator.Type: ApplicationFiled: August 20, 2004Publication date: February 23, 2006Inventors: Ana San Gabriel, Hisayuki Uneyama, Takami Maekawa, Kunio Torii
-
Patent number: 6995179Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.Type: GrantFiled: December 13, 2001Date of Patent: February 7, 2006Assignee: Ajinomoto Co., Inc.Inventors: Hisayuki Uneyama, Seiji Niwa, Tomoyuki Onishi
-
Publication number: 20050282746Abstract: It is intended to disclose a glutamate sensor in taste sensation and digestion and provide techniques using the same. A glutamate-receptor protein having the following characteristics is reacted with a substance binding thereto in the presence of a test substance and thus the inhibition or acceleration of the reaction is detected to thereby search for a glutamate agonist or antagonist or an allosteric modulator: (1) having a transmembrane domain and an intracellular domain common to a type 1 metabolic glutamate receptor protein; and (2) having an extracellular domain shorter by about 409 or 481 amino acid residues than the type 1 metabolic glutamate receptor protein.Type: ApplicationFiled: December 10, 2004Publication date: December 22, 2005Inventors: Ana Gabriel, Hisayuki Uneyama, Takami Maekawa, Kunio Torii