Patents by Inventor Hongbo Peng
Hongbo Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230416198Abstract: The present disclosure provides a method for continuously and efficiently preparing taurine, including:(a) bringing an ethylene oxide with an alkali metal bisulfite into an addition reaction to obtain an alkali metal isethionate; (b) bringing the alkali metal isethionate with an ammonia into an ammonolysis reaction to obtain a solution containing alkali metal taurinate; and (c) inputting the solution containing alkali metal taurinate into at least one acid cation exchange resin column in activated state to obtain the taurine through an acidification treatment, followed by activating a portion of the at least one acid cation exchange resin column by a first activation manner using sulfurous acid and obtaining a solution containing alkali metal bisulfite, and activating another portion of the at least one acid cation exchange resin column by a second activation manner using sulfuric acid, wherein the first and second activation manner may be performed on a same acid cation exchange resin column alternatingly orType: ApplicationFiled: August 25, 2023Publication date: December 28, 2023Applicant: HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Huajun SUN, Min TAN, Xiaojing YAN, Ruyong JIANG, Hongbo PENG, Jiale TANG, Chen GUO, Xingxing WANG, Zhiqiang QIAN
-
Patent number: 11840502Abstract: The present disclosure provides a system for efficiently preparing taurine, including: a solution storage unit configured to store a solution containing alkali metal taurinate, the solution being prepared by an ethylene oxide process; an ion exchange unit including at least one ion exchange resin column each configured to be activated by a first activation manner or a second activation manner independently, the first activation manner using sulfurous acid for activation to obtain alkali metal bisulfate and taurine, and the second activation manner using sulfuric acid for activation to obtain alkali metal sulfate and taurine; and a dispensing unit connected to the solution storage unit and the ion exchange unit respectively, and configured to adjust an amount of a solution conveyed from the solution storage unit to each of the at least one ion exchange resin column in the ion exchange unit.Type: GrantFiled: June 24, 2022Date of Patent: December 12, 2023Assignee: HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Huajun Sun, Min Tan, Xiaojing Yan, Ruyong Jiang, Hongbo Peng, Jiale Tang, Chen Guo, Xingxing Wang, Zhiqiang Qian
-
Publication number: 20220324793Abstract: The present disclosure provides a system for efficiently preparing taurine, including: a solution storage unit configured to store a solution containing alkali metal taurinate, the solution being prepared by an ethylene oxide process; an ion exchange unit including at least one ion exchange resin column each configured to be activated by a first activation manner or a second activation manner independently, the first activation manner using sulfurous acid for activation to obtain alkali metal bisulfate and taurine, and the second activation manner using sulfuric acid for activation to obtain alkali metal sulfate and taurine; and a dispensing unit connected to the solution storage unit and the ion exchange unit respectively, and configured to adjust an amount of a solution conveyed from the solution storage unit to each of the at least one ion exchange resin column in the ion exchange unit.Type: ApplicationFiled: June 24, 2022Publication date: October 13, 2022Applicant: HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Huajun SUN, Min TAN, Xiaojing YAN, Ruyong JIANG, Hongbo PENG, Jiale TANG, Chen GUO, Xingxing WANG, Zhiqiang QIAN
-
Patent number: 10604478Abstract: Provided is a method for producing taurine including: providing a reaction solution comprising alkali metal taurinate and/or alkali metal isethionate, passing at least a portion of the reaction solution through a column of basic anion exchange resin, adsorbing anions of alkali metal taurinate and/or alkali metal isethionate to the basic anion exchange resin, and collecting an eluate comprising at least one impurity, desorbing anions of alkali metal taurinate and/or alkali metal isethionate from the basic anion exchange resin with an alkaline solution, and collecting a desorption liquid comprising alkali metal taurinate and/or alkali metal isethionate, subjecting the desorption liquid comprising alkali metal taurinate to acidification or subjecting the desorption liquid comprising alkali metal isethionate to aminolysis and acidification, thereby obtaining taurine.Type: GrantFiled: August 22, 2019Date of Patent: March 31, 2020Assignee: HUBEI GRAND LIFE SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Huajun Sun, Hongbo Peng, Ruyong Jiang, Chen Guo, Zhiqiang Qian
-
Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing
Patent number: 10385390Abstract: A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges or dipoles passing through the nanopore.Type: GrantFiled: June 29, 2017Date of Patent: August 20, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Gustavo A. Stolovitzky, Wenjuan Zhu -
Patent number: 10267784Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: GrantFiled: November 11, 2016Date of Patent: April 23, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
-
Patent number: 10082483Abstract: A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel.Type: GrantFiled: February 19, 2015Date of Patent: September 25, 2018Assignee: GLOBALFOUNDRIES INC.Inventor: Hongbo Peng
-
Patent number: 10040682Abstract: A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.Type: GrantFiled: May 7, 2012Date of Patent: August 7, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Gustavo A. Stolovitzky, Deqiang Wang
-
Patent number: 10029915Abstract: A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.Type: GrantFiled: April 4, 2012Date of Patent: July 24, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Gustavo A. Stolovitzky, Deqiang Wang
-
GRAPHENE TRANSISTOR GATED BY CHARGES THROUGH A NANOPORE FOR BIO-MOLECULAR SENSING AND DNA SEQUENCING
Publication number: 20170298429Abstract: A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges or dipoles passing through the nanopore.Type: ApplicationFiled: June 29, 2017Publication date: October 19, 2017Inventors: Hongbo Peng, Gustavo A. Stolovitzky, Wenjuan Zhu -
Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing
Patent number: 9765392Abstract: A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges or dipoles passing through the nanopore.Type: GrantFiled: May 22, 2012Date of Patent: September 19, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Gustavo A. Stolovitzky, Wenjuan Zhu -
Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing
Patent number: 9758822Abstract: A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges or dipoles passing through the nanopore.Type: GrantFiled: January 24, 2014Date of Patent: September 12, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Gustavo A. Stolovitzky, Wenjuan Zhu -
Graphene transistor gated by charges through a nanopore for bio-molecular sensing and DNA sequencing
Patent number: 9758821Abstract: A technique for a nanodevice is provided. A reservoir is separated into two parts by a membrane. A nanopore is formed through the membrane, and the nanopore connects the two parts of the reservoir. The nanopore and the two parts of the reservoir are filled with ionic buffer. The membrane includes a graphene layer and insulating layers. The graphene layer is wired to first and second metal pads to form a graphene transistor in which transistor current flowing through the graphene transistor is modulated by charges passing through the nanopore.Type: GrantFiled: April 17, 2012Date of Patent: September 12, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Gustavo A. Stolovitzky, Wenjuan Zhu -
Patent number: 9651518Abstract: The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.Type: GrantFiled: November 17, 2014Date of Patent: May 16, 2017Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Glenn J. Martyna, Dennis M. Newns, Hongbo Peng, Stanislav Polonsky, Stephen Rossnagel, Gustavo Stolovitzky
-
Publication number: 20170059548Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: ApplicationFiled: November 11, 2016Publication date: March 2, 2017Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
-
Patent number: 9513277Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: GrantFiled: January 25, 2016Date of Patent: December 6, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
-
Patent number: 9453831Abstract: A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.Type: GrantFiled: April 21, 2012Date of Patent: September 27, 2016Assignee: GlobalFoundries Inc.Inventors: Stanislav Polonsky, Ali Afzali-Ardakani, Hongbo Peng, Gustavo A. Stolovitzky, Ajay A. Royyuru, Mark N. Wegman
-
Publication number: 20160139105Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: ApplicationFiled: January 25, 2016Publication date: May 19, 2016Inventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
-
Patent number: 9285339Abstract: A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.Type: GrantFiled: February 18, 2015Date of Patent: March 15, 2016Assignee: International Business Machines CorporationInventors: Ali Afzali-Ardakani, Stefan Harrer, Binquan Luan, Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Philip S. Waggoner
-
Patent number: 9222930Abstract: A mechanism is provided for forming a nanodevice. A reservoir is filled with a conductive fluid, and a membrane is formed to separate the reservoir in the nanodevice. The membrane includes an electrode layer having a tunneling junction formed therein. The membrane is formed to have a nanopore formed through one or more other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. The tunneling junction of the electrode layer is narrowed to a narrowed size by electroplating or electroless deposition. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.Type: GrantFiled: August 20, 2013Date of Patent: December 29, 2015Assignee: GLOBALFOUNDRIES INC.Inventors: Hongbo Peng, Stephen M. Rossnagel, Ajay K. Royyuru, Gustavo A. Stolovitzky, Deqiang Wang