Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Abstract: Disclosed are methods and compositions for treating and/or preventing hernias in subjects in need thereof. The disclosed methods of treatment and/or preventing may include methods for treating and/or preventing hernias in subject in need thereof by administering to the subject a therapeutic agent that modulates sex steroid hormone production and/or activity in the subject. Hernias treated and/or prevented by the disclosed methods may include, but are not limited to, inguinal hernias, femoral hernias, umbilical hernias, hiatal hernias, incisional hernias, and diastasis recti.

Abstract: The invention provides a selecting method for domestic rabbits with a agouti/Belgian hair color based on homozygous genotype selection. The purification method is applicable to purification of various domestic rabbits with the agouti/Belgian hair color. The method includes the following steps: firstly, selecting the domestic rabbits with a hair color phenotype which is the agouti/Belgian hair color; then detecting an ASIP gene, a MC1R gene and a TYR gene at the same time by utilizing a first primer set, a second primer set and a third primer set; screening the domestic rabbits with genotypes of AA (corresponding to the ASIP gene), EE (corresponding to the MC1R gene) and CC (corresponding to the TYR gene). The domestic rabbits with the genotype of AAEECC, which are obtained by the screening method of the invention, are agouti/Belgian hair color homozygotes and the recessive white gene is eliminated.

Abstract: Electrolytes and electrolyte additives for energy storage devices comprising cyanate based compounds are disclosed. The energy storage device comprises a first electrode and a second electrode, wherein at least one of the first electrode and the second electrode is a Si-based electrode, a separator between the first electrode and the second electrode, an electrolyte comprising at least two electrolyte co-solvents, wherein at least one electrolyte co-solvent comprises a cyanate based compound.

Abstract: A method for partitioning a search direction when using least squares reverse time migration (LSRTM) is provided. LSRTM may be used iteratively in order to improve imaging accuracy. As part of LSRTM, multiple local line searches may be performed. In particular, image space may be partitioned, such as by using a set of masks. The search direction, such as the gradient, may be partitioned using the set of masks. Local line searches may be performed for each partition of the search direction, resulting in finding respective line search constants. The respective line search constants may then be used for iterating the model in order to improve imaging accuracy.

Abstract: Provided are a memory lymphocyte population, a culture medium, and a method for obtaining the memory lymphocyte population and a use of the same. The memory lymphocyte population contains at least one of the following marker molecules: leukocyte differentiation antigens CD3, CD4, CD8, CD16, CD56, CD62L and CD45RO.

Abstract: A method for replaying operations on a widget in a graphical user interface (GUI) includes acquiring, from an operation record, operation information related to the widget and a first unique identification (UID) of the widget. A widget having a second UID is determined, wherein the second UID is generated based on a call stack for creating the widget in the GUI. The second UID is the same as the first UID. It may be determined whether the widget on the GUI is operable. An operation is executed on the widget according to the operation information related to the widget.

Abstract: A method for replaying operations on a widget in a graphical user interface (GUI) includes acquiring, from an operation record, operation information related to the widget and a first unique identification (UID) of the widget. A widget having a second UID is determined, wherein the second UID is generated based on a call stack for creating the widget in the GUI. The second UID is the same as the first UID. It may be determined whether the widget on the GUI is operable. An operation is executed on the widget according to the operation information related to the widget.

Abstract: Electrolytes and electrolyte additives for energy storage devices comprising dihydrofuranone based compounds are disclosed. The energy storage device comprises a first electrode and a second electrode, wherein at least one of the first electrode and the second electrode is a Si-based electrode, a separator between the first electrode and the second electrode, an electrolyte comprising at least two electrolyte co-solvents, wherein at least one electrolyte co-solvent comprises a dihydrofuranone based compound.

Abstract: An electrohydrodynamic (EHD) jet printing apparatus or system may include circulation of printing fluid to minimize or eliminate clogging in a nozzle. An exemplary nozzle comprises at least two ink channels—one allowing flow to a droplet emitting opening and one allowing flow away from the droplet emitting opening—configured for circulating ink. The nozzle may transfer ink to a substrate with an EHD technique involving voltage or current modulation. For example, an electric field may be applied between the nozzle and printing substrate such that the ink meniscus changes shape and releases ink from the tip of the liquid cone. A multi-channel nozzle may take a variety of configurations, including two co-axially aligned capillaries, side-by-side parallel capillaries, or capillaries arranged at an angle with respect to one another but converging at a single point where the conical meniscus is formed.

Abstract: An electronic device includes a device housing and at least two grip sensors disposed along the device housing. One or more processors are operable with the at least two grip sensors. At least one electronic latch is operable with the one or more processors. The one or more processors transition the at least one electronic latch from a latched state to an unlatched state when the at least two grip sensors detect a grip applied to the at least two grip sensors.

Abstract: In an approach, data of a plurality of points is sampled in a target area, wherein the data of each point of the plurality of points comprises position information and a height value. A first area of a target area is determined, wherein the height value of each point of the plurality of points in the first area complies with a first range. A second area of the target area is determined, wherein the height value of each point of the plurality of points in the second area complies with a second range. A third area of the target area is determined, wherein the height value of each point of the plurality of points in the third area complies with a third range. A first pattern is generated, wherein the first pattern is a combination of the first area and the third area.

Abstract: Systems and methods provide a new paradigm of Advanced Process Control that includes building and deploying APC seed models. Embodiments provide automated data cleansing and selection in model identification and adaption in multivariable process control (MPC) techniques. Rather than plant pre-testing onsite for building APC seed models, the embodiments help APC engineers to build APC seed models from existing plant historical data with self-learning automation and pattern recognition, AI techniques. Embodiments further provide “growing” and “calibrating” the APC seed models online with non-invasive closed loop step testing techniques. PID loops and associated SP, PV, and OPs are searched and identified. Only “informative moves” data is screened, identified, and selected among a long history of process variables for seed model development and MPC application.

Abstract: A system and method of facilitating user interaction with a mobile electronic communication device is provided, for devices having a touch sensitive screen and a housing surface. The described techniques entail displaying visual matter on the touch sensitive screen, detecting a touch on the housing surface, the detected touch having a touch location and touch pressure, and modifying the appearance of the visual matter on the touch sensitive screen based on the touch location and touch pressure.

Abstract: A three-dimensional object printing system comprises a ejectors configured to eject drops of material towards a platen, a heater, a sensor configured to sense temperature of the ejected material, a radiator configured to direct radiation to the ejected material, a cooler configured to cool the ejected material, and a controller operatively connected to the ejectors, heater, sensor radiator and cooler. The controller is configured to control the ejectors to form layers of material for a three-dimensional object on the surface of the platen with reference to image data of the three-dimensional object, to operate the heater to heat the surface of the platen, to compare a temperature signal received from the sensor to a predetermined threshold, to operate the radiator to radiate the object layers, and to operate the cooler to attenuate heat produced by the radiated material in response to the signal from sensor exceeding the predetermined threshold.

Abstract: The disclosure includes a platinum-based alloy catalyst and a preparation method thereof, a membrane electrode and a fuel cell. The method for preparing the platinum-based alloy catalyst comprises the following steps: (1) preparing nano-sized alloy particles of platinum and 3d transition metal; (2) carrying out acid treatment on the alloy particles prepared in step (1); and (3) annealing the alloy particles treated in step (2). The size of the platinum-based alloy particles is controlled, an atom number ratio of platinum to transition metal in the platinum-based alloy is controlled, and then etching and dissolution of acid is combined so that an atom number ratio of platinum to transition metal is further controlled, subsequently annealing is carried out at high temperature. The prepared platinum-based alloy catalyst improves the stability and durability of the platinum-based alloy catalyst, which supports the large-scale application of the platinum-based alloy catalyst in the fuel cell.

Abstract: Embodiments are directed to computer methods and systems that build and deploy a pattern model to detect an operating event in an online plant process. To build the pattern model, the methods and systems define a signature of the operating event, such that the defined signature contains a time series pattern for a KPI associated with the operating event. The methods and systems deploy the pattern model to automatically monitor, during online execution of the plant process, trends in movement of the KPI as a time series. The methods and systems determine, in real-time, a distance score between a range of the monitored time series and the time series pattern contained in the defined signature. The methods and systems automatically detect the operating event in the online industrial process based on the determined distance score, and alter parameters of the process (e.g., valves, actuators, etc.) to prevent the operating event.

Abstract: An audio input method includes: in an audio-input mode, receiving a first audio input by a user, recognizing the first audio to generate a first recognition result, and displaying corresponding verbal content to the user based on the first recognition result; and in an editing mode, receiving a second audio input by the user and recognizing and generating a second recognition result, converting the second recognition result to an editing instruction, and executing a corresponding operation based on the editing operation. The audio-input mode and the editing mode are switchable.

Abstract: Seismic data processing may include computing the travel time shift between two seismic signals or the depth shift between two seismic images. In Full Waveform Inversion (FWI), the travel time difference between an observed trace and a simulated trace may be computed such that the two traces match after the travel time shift is applied to the observed trace. The travel time shift may be computed based on a constrained optimization that maximizes the windowed cross-correlation between the two seismic traces by constraining the time derivative of the travel time shift to be less than a constant while maximizing the windowed cross-correlation. Further, the travel time shift may be computed during the model line search in FWI by computing a plurality of travel time shifts where a first travel time shift is dependent on the observed trace and a second travel time shift is independent of the observed trace.

Abstract: The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein. using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.