Patents by Inventor Horst Schwinn

Horst Schwinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6528246
    Abstract: A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55° C. to 67° C. for five hours to 30 hours.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: March 4, 2003
    Assignee: Octapharma AG
    Inventors: Monika Stadler, Horst Schwinn, Djuro Josic, Werner Gehringer, Frederic Bal
  • Publication number: 20020068355
    Abstract: A method for the inactivation of viruses, in particular those having no lipid coats, in protein-containing compositions from blood, blood plasma or similar natural sources by treating said source, simultaneously or succesively, with an effective amount of dialkyl or trialkyl phosphates and optionally surfactants at an elevated temperature in the range of from 55° C. to 67° C. for five hours to 30 hours.
    Type: Application
    Filed: September 28, 1995
    Publication date: June 6, 2002
    Inventors: MONIKA STADLER, HORST SCHWINN, DJURO JOSIC, WERNER GEHRINGER, FREDERIC BAL
  • Patent number: 6143179
    Abstract: The invention concerns a process for the purification of factor VIII by affinity chromatography characterized in that a biological fluid containing factor VIII is contacted with immobilized cellular von Willebrand factor or a derivative thereof under such conditions that factor VIII is adsorbed to the immobilized von Willebrand factor or derivative thereof, impurities are separated and adsorbed factor VIII is eluted.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 7, 2000
    Assignee: Kerckhoff-Klinik GmbH
    Inventors: Gert Muller-Berghaus, Bernd Potzsch, Horst Schwinn
  • Patent number: 6136865
    Abstract: A method for reduction of the viral infectiousness of potentially infectious material, such as human or animal body fluids or fractions derived therefrom from which biologically active substances can be isolated, wherein the infectiousness is due to non-lipid-coated viruses characterized in thatsaid potentially infectious material for the isolation of said biologically active substances is treated witha hydrophobic phase which is essentially insoluble in water and is capable of forming a two-phase system with said potentially infectious material, andsaid hydrophobic phase is separated from the potentially infectious material thus treated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 24, 2000
    Assignee: Octapharma AG
    Inventors: Lothar Biesert, Horst Schwinn, Wolfgang Marguerre
  • Patent number: 6007979
    Abstract: A method for reduction of the viral infectiousness of potentially infectious material, such as human or animal body fluids or fractions derived therefrom from which biologically active substances can be isolated, wherein the infectiousness is due to non-lipid-coated viruses characterized in thatsaid potentially infectious material for the isolation of said biologically active substances is treated witha hydrophobic phase which is essentially insoluble in water and is capable of forming a two-phase system with said potentially infectious material, andsaid hydrophobic phase is separated from the potentially infectious material thus treated.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: December 28, 1999
    Assignee: Octapharma AG
    Inventors: Wolfgang Marguerre, Horst Schwinn, Lothar Biesert
  • Patent number: 5714590
    Abstract: Described is an economical process for the recovery of factor VIII from blood plasma or cryoprecipitate. In the process, anion exchanger chromatography is conducted using a separating material based on carriers containing hydroxyl groups, the surfaces of which carriers have been coated with covalently boded polymers. The polymers contain repeating units represented by formula (I).
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: February 3, 1998
    Assignee: Octapharma AG
    Inventors: Monika Stadler, Horst Schwinn
  • Patent number: 5328694
    Abstract: A stable, injectable solution containing factor VIII suitable for the treatment of humans, natural or synthetic disaccharides, preferably saccharose, in concentrations of from 0.1 to 0.65 mol/1, and one or more amino acids in concentrations of from 0.1 to 1.0 mol/1. A process for preparing same and the use of natural or synthetic disaccharides, preferably saccharose, and one or more amino acids for stabilizing factor VIII.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: July 12, 1994
    Assignee: Octapharma AG
    Inventor: Horst Schwinn
  • Patent number: 4670544
    Abstract: What is disclosed is a method for isolating the cold insoluble globulin (CIG) from blood plasma concentrates containing factor VIII.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: June 2, 1987
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger, Gerhard Kumpe, Bernd Herchenhan
  • Patent number: 4442213
    Abstract: What is disclosed is a process for rendering plasminogen virtually free of hepatitis virus by heating a plasminogen solution in the presence of a proteinase inhibitor with plasmin specificity, an amino acid, and a saccharide or sugar alcohol.
    Type: Grant
    Filed: May 12, 1982
    Date of Patent: April 10, 1984
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Helmut Heber, Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Manfred Schick
  • Patent number: 4411794
    Abstract: A process for purifying liquids containing blood clotting factors by adsorption of the factors on mineral adsorbents such as calcium phosphate, aluminum hydroxide gel, barium sulfate or hydroxylapatite in the presence of calcium ions followed by elution is described.
    Type: Grant
    Filed: January 19, 1982
    Date of Patent: October 25, 1983
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Heinz H. Drescher
  • Patent number: 4405603
    Abstract: What is disclosed is a method for making a preparation containing blood clotting Factors IX and/or X virtually hepatitis-safe by warming said peparation in the presence of calcium ions and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: September 20, 1983
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Wilfried Wormsbacher
  • Patent number: 4404187
    Abstract: What is disclosed is a method for treating a preparation containing blood clotting Factors II and/or VII to render it virtually hepatitis-free by warming said preparation in the presence of a chelating agent and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: September 13, 1983
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Hans M. Preis
  • Patent number: 4297344
    Abstract: A process for stabilizing the coagulation factors II, VIII, XIII, antithrombin III and plasminogen against heat is described. The preparations obtained according to this process are practically free from coagulable fibrinogen.
    Type: Grant
    Filed: April 23, 1980
    Date of Patent: October 27, 1981
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger, Gerhardt Kumpe, Bernd Herchenhan
  • Patent number: 4067964
    Abstract: The invention relates to an antihemophilic agent, which may contain factor VIII, but also factor IV, VII and X activities and to a process for its manufacture by extracting placentae with an aqueous hypotonic medium, increasing the density of the extract and obtaining the supernatant layer forming thereupon.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: January 10, 1978
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Horst Schwinn, Norbert Heimburger
  • Patent number: 4056484
    Abstract: Lyophilized blood plasma under a protective gas wherein the protective gas contains at least 5% of carbon dioxide.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: November 1, 1977
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Norbert Heimburger, Axel Sieber, Horst Schwinn
  • Patent number: 3983004
    Abstract: A diagnostic agent containing thromboplastin sensitive to factor VII and factor X for measuring the coagulability of blood is prepared by extracting an aqueous suspension of thrombogenic tissue at pH 10 to 12, acidifying the extract, separating the extract from the tissue and adding a water-soluble calcium salt to the extract. The agent can be stabilized by adding to the extract cholanic acid and a water-soluble heavy metal-II-salt.
    Type: Grant
    Filed: November 11, 1974
    Date of Patent: September 28, 1976
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Heiner Trobisch, Horst Schwinn
  • Patent number: 3980432
    Abstract: The present invention relates to a process for preparing partial thromboplastin which comprises extracting bloodless dry placentae with an organic solvent, separating the extract from the undissolved substance, evaporating, dispersing the residue in water and adding, if desired, a stabilizer and/or lyophilizing. It further relates to the partial thromboplastin thus obtained and to its use as diagnostic agent.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: September 14, 1976
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Heiner Trobisch, Horst Schwinn