Patents by Inventor Hosheng Tu
Hosheng Tu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160100983Abstract: Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.Type: ApplicationFiled: October 12, 2015Publication date: April 14, 2016Inventors: Hosheng Tu, Jason Artof, David Steven Haffner, Gregory T. Smedley, Barbara A. Niksch
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Patent number: 9301875Abstract: Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.Type: GrantFiled: March 18, 2005Date of Patent: April 5, 2016Assignee: GLAUKOS CORPORATIONInventors: Hosheng Tu, Jason Artof, David Steven Haffner, Gregory T. Smedley, Barbara A. Niksch
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Patent number: 9220632Abstract: Methods of treating ocular disorders are disclosed, including: inserting an implant in eye tissue, using an instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.Type: GrantFiled: December 20, 2013Date of Patent: December 29, 2015Assignee: GLAUKOS CORPORATIONInventors: Gregory Smedley, David Haffner, Hosheng Tu
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Patent number: 9155654Abstract: Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.Type: GrantFiled: February 17, 2012Date of Patent: October 13, 2015Assignee: GLAUKOS CORPORATIONInventors: Hosheng Tu, Jason Artof, David Steven Haffner, Gregory T. Smedley, Barbara A. Niksch
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Publication number: 20150265394Abstract: Methods and devices with two individual tubes for treating abdominal aortic aneurysm that bypass the aneurysm and are placed from the upper aorta to the iliac arteries. A separate upper cuff may also be provided, to secure the tubes above the aneurysm.Type: ApplicationFiled: December 16, 2014Publication date: September 24, 2015Inventors: Andrew H. Cragg, Rodolfo C. Quijano, Hosheng Tu, Stephen Sosnowski, Robert J. Socci, JR., George Wallace
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Publication number: 20150223981Abstract: A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.Type: ApplicationFiled: November 10, 2014Publication date: August 13, 2015Inventors: Gregory T. Smedley, David Haffner, Barbara Niksch, Hosheng Tu, Thomas W. Burns
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Patent number: 9066782Abstract: Implants and methods for treating ocular disorders are provided. One method involves introducing an implant into an anterior chamber of an eye. The implant is implanted into eye tissue adjacent the anterior chamber such that a proximal end of the implant resides in the anterior chamber following implantation. A therapeutic agent is eluted from the implant into the eye. Desirably, the release of the therapeutic agent from the implant is controlled. The controlled release of the therapeutic agent can be at a chosen rate and/or for a selected duration which can be episodic or periodic. The therapeutic agent can be an antiproliferative agent, an anti-inflammatory drug, or a compound for treating glaucoma or ocular hypertension.Type: GrantFiled: December 17, 2012Date of Patent: June 30, 2015Assignee: Dose Medical CorporationInventors: Hosheng Tu, Barbara A Niksch, David S Haffner, Gregory T Smedley, Olav B Bergheim, Morteza Gharib, Richard A. Hill, Thomas W. Burns
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Publication number: 20140343475Abstract: Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.Type: ApplicationFiled: December 20, 2013Publication date: November 20, 2014Inventors: Gregory T. Smedley, David S. Haffner, Hosheng Tu
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Patent number: 8882781Abstract: A method is provided for treatment of cataract in combination with a glaucoma procedure while maintaining the intraocular pressure by permitting aqueous to flow out of an anterior chamber of the eye through a surgically stented pathway. A trabecular stent is adapted for implantation within the trabecular meshwork of an eye such that intraocular liquid flows controllably from the anterior chamber of the eye to Schlemm's canal, bypassing the trabecular meshwork. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular stent enabling post-cataract healing processes.Type: GrantFiled: May 27, 2011Date of Patent: November 11, 2014Assignee: Glaukos CorporationInventors: Gregory T Smedley, David Haffner, Barbara Niksch, Hosheng Tu, Thomas W Burns
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Patent number: 8791069Abstract: The invention discloses use of a pharmaceutical composition for slow-release delivery of a bioactive agent, comprising mixing the bioactive agent with a partially hydrophobic chitosan solution at a low pH and delivering the hydrogel at a physiological pH to transform the hydrogel to a solid complex for releasing the bioactive agent. The partially hydrophobic chitosan is characterized by presence of alternating charges of protonated amine groups and hydrophobic side groups.Type: GrantFiled: July 7, 2012Date of Patent: July 29, 2014Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Hosheng Tu
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Publication number: 20140163652Abstract: A catheter system for repairing an annular organ structure of a patient, comprising: intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements; and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure. Tissue-shrinkable energy is infrared energy, ultrasound energy, focused ultrasound energy, ultrasound energy, radiofrequency energy, microwave energy, electromagnetic energy, laser energy, or a combination thereof.Type: ApplicationFiled: December 10, 2012Publication date: June 12, 2014Inventors: THOMAS WITZEL, WALLACE N. HAUCK, JOHN A. OSTH, HOSHENG TU
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Patent number: 8663599Abstract: The invention discloses a pharmaceutical composition of pH-sensitive liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein the compound is in vesicles of the liposomes. A light or UV light is provided to induce the photosensitive compound to release the protons, thus the released protons causing the pH-sensitive liposome to decompose.Type: GrantFiled: November 21, 2012Date of Patent: March 4, 2014Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Zi-Xian Liao, Min-Fan Chung, Ko-Jie Chen, Po-Yuan Cheng, Hosheng Tu
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Patent number: 8617094Abstract: Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye.Type: GrantFiled: January 12, 2006Date of Patent: December 31, 2013Assignee: Glaukos CorporationInventors: Gregory Smedley, David Haffner, Hosheng Tu
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Publication number: 20130310930Abstract: The invention relates generally to medical devices and methods for the treatment of ocular disorders. An ocular implant having an inlet portion with a first anchor and an outlet portion with a second anchor is provided. The first anchor is configured to be positioned adjacent eye tissue, for example, within an anterior chamber of an eye, and the second anchor is configured to be positioned within a physiological outflow pathway of the eye. The implant, when implanted in the eye, is configured to conduct fluid from the anterior chamber to the physiological outflow pathway. Desirably, the second anchor is deployable and is configured to secure the implant within the physiological outflow pathway. Also provided is an ocular treatment method which involves implanting the implant to secure the implant within the physiological outflow pathway by deploying the second anchor.Type: ApplicationFiled: December 21, 2012Publication date: November 21, 2013Applicant: GLAUKOS CORPORATIONInventors: Hosheng Tu, Gregory T. Smedley, Barbara A. Niksch, David S. Haffner
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Patent number: 8579846Abstract: Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.Type: GrantFiled: November 21, 2011Date of Patent: November 12, 2013Assignee: Glaukos CorporationInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Patent number: 8574544Abstract: The invention discloses a pharmaceutical composition of nanoparticles consisting of chitosan, a negatively charged substrate, and at least one bioactive agent that is encapsulated within cucurbiturils for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.Type: GrantFiled: December 21, 2012Date of Patent: November 5, 2013Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Ha Giang Thi Nguyen, Fang Yi Su, Er-Yuan Chuang, Zi-Xian Liao, Hosheng Tu
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Publication number: 20130281910Abstract: The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.Type: ApplicationFiled: March 5, 2013Publication date: October 24, 2013Inventor: Hosheng Tu
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Publication number: 20130253404Abstract: Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.Type: ApplicationFiled: March 5, 2013Publication date: September 26, 2013Applicant: Glaukos CorporationInventor: Hosheng Tu
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Publication number: 20130253405Abstract: Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.Type: ApplicationFiled: March 5, 2013Publication date: September 26, 2013Applicant: Glaukos CorporationInventor: Hosheng Tu
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Publication number: 20130245532Abstract: The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.Type: ApplicationFiled: March 5, 2013Publication date: September 19, 2013Applicant: Glaukos CorporationInventor: Hosheng Tu