Patents by Inventor Howard J. Federoff
Howard J. Federoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11808774Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: January 25, 2021Date of Patent: November 7, 2023Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Publication number: 20220401404Abstract: Described herein are materials and methods for the treatment of neurodegenerative diseases by administering a combination of fenofibrate and kaempferol.Type: ApplicationFiled: February 5, 2020Publication date: December 22, 2022Inventors: Howard J. Federoff, Sudhakar Raja Subramaniam, Massimo S. Fiandaca, Mark E. Mapstone, Xiaomin Su
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Publication number: 20220211654Abstract: Described herein are materials and methods for the treatment of age-related macular degeneration by administering a combination of fenofibrate and an esterase inhibitor (e.g., kaempferol or telmisartan).Type: ApplicationFiled: May 6, 2020Publication date: July 7, 2022Inventors: Howard J. Federoff, Sudhakar Raja Subramaniam, Sonali Nashine, M. Cristina Kenney
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Patent number: 11280797Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.Type: GrantFiled: February 2, 2018Date of Patent: March 22, 2022Assignees: Georgetown University, University of RochesterInventors: Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema
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Publication number: 20210298601Abstract: Embodiments herein relate to biosensors and other elements combined in real-time for health applications that acquire health data of an individual from one or more data streams by a first element and integrate these data through a second element that is configured to predict and/or recognize an interruptive health event and then via one or more successive elements alert one or more providers of a possible interruptive health event, enable the providers to propose one or more effective interventions, communicate directly with the individual and providers and/or caregivers, and/or provide confirmation in the event that effective interventions were made. Embodiments also relate to predicting and recognizing brain attack in real-time by acquiring and integrating health data from one or more data streams, interfacing with one or more providers so that they can propose and/or effect one or more effective interventions, and communicating with an affected individual, providers, and/or caregivers.Type: ApplicationFiled: March 15, 2021Publication date: September 30, 2021Inventors: Howard J. Federoff, Ophir Frieder, Massimo S. Fiandaca, Ramesh Jain
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Publication number: 20210285973Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: January 25, 2021Publication date: September 16, 2021Applicants: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Patent number: 10945604Abstract: Embodiments herein relate to biosensors and other elements combined in real-time for health applications that acquire health data of an individual from one or more data streams by a first element and integrate these data through a second element that is configured to predict and/or recognize an interruptive health event and then via one or more successive elements alert one or more providers of a possible interruptive health event, enable the providers to propose one or more effective interventions, communicate directly with the individual and providers and/or caregivers, and/or provide confirmation in the event that effective interventions were made. Embodiments also relate to predicting and recognizing brain attack in real-time by acquiring and integrating health data from one or more data streams, interfacing with one or more providers so that they can propose and/or effect one or more effective interventions, and communicating with an affected individual, providers, and/or caregivers.Type: GrantFiled: August 24, 2018Date of Patent: March 16, 2021Assignee: NaviSalute, LLCInventors: Howard J Federoff, Ophir Frieder, Massimo S. Fiandaca, Ramesh Jain
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Patent number: 10900980Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: May 18, 2016Date of Patent: January 26, 2021Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Patent number: 10900977Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: October 17, 2016Date of Patent: January 26, 2021Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone, Xiaogang Zhong
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Patent number: 10890589Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: May 27, 2015Date of Patent: January 12, 2021Assignees: Georgetown University, University of RochesterInventors: Massimo S. Fiandaca, Mark E. Mapstone, Howard J. Federoff, Xiaogang Zhong, Amrita K. Cheema
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Publication number: 20200363436Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PUFAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: June 1, 2020Publication date: November 19, 2020Applicant: Georgetown UniversityInventors: Massimo S. Fiandaca, Howard J. Federoff
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Publication number: 20200239959Abstract: Methods of determining if a subject has an increased risk of poor recovery after suffering a stroke and methods of treating a subject recovering from a stroke. The methods comprise analyzing at least one plasma sample taken from the subject to assess a microRNA (miRNA) profile of the subject and comparing the subject's miRNA profile with a normal miRNA profile, to determine if the subject's miRNA profile is altered compared to a normal miRNA profile. An alteration of the subject's miRNA profile is indicative that the subject has an increased risk of poor recovery after suffering a stroke.Type: ApplicationFiled: January 24, 2020Publication date: July 30, 2020Applicant: Georgetown UniversityInventors: Matthew A. Edwardson, Xiaogang Zhong, Massimo S. Fiandaca, Howard J. Federoff, Amrita K. Cheema, Alexander W. Dromerick
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Patent number: 10718021Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value of the subject's gene expression profile, above or below normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: May 28, 2015Date of Patent: July 21, 2020Assignees: GEORGETOWN UNIVERSITY, UNIVERSITY OF ROCHESTERInventors: Massimo S. Fiandaca, Mark E. Mapstone, Yuriy Gusev, Howard J. Federoff
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Patent number: 10670617Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PUFAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: June 8, 2016Date of Patent: June 2, 2020Assignee: GEORGETOWN UNIVERSITYInventors: Massimo S. Fiandaca, Howard J. Federoff
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Patent number: 10578629Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: April 21, 2016Date of Patent: March 3, 2020Assignees: GEORGETOWN UNIVERSITY, UNIVERSITY OF ROCHESTERInventors: Howard J. Federoff, Mark E. Mapstone, Amrita K. Cheema, Massimo S. Fiandaca
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Publication number: 20200060543Abstract: Embodiments herein relate to biosensors and other elements combined in real-time for health applications that acquire health data of an individual from one or more data streams by a first element and integrate these data through a second element that is configured to predict and/or recognize an interruptive health event and then via one or more successive elements alert one or more providers of a possible interruptive health event, enable the providers to propose one or more effective interventions, communicate directly with the individual and providers and/or caregivers, and/or provide confirmation in the event that effective interventions were made. Embodiments also relate to predicting and recognizing brain attack in real-time by acquiring and integrating health data from one or more data streams, interfacing with one or more providers so that they can propose and/or effect one or more effective interventions, and communicating with an affected individual, providers, and/or caregivers.Type: ApplicationFiled: August 24, 2018Publication date: February 27, 2020Inventors: Howard J. Federoff, Ophir Frieder, Massimo S. Fiandaca, Ramesh Jain
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Publication number: 20200011881Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.Type: ApplicationFiled: February 2, 2018Publication date: January 9, 2020Applicants: Georgetown University, University of RochesterInventors: Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema
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Publication number: 20180306811Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: October 17, 2016Publication date: October 25, 2018Applicants: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone, Xiaogang Zhong
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Publication number: 20180196073Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PU FAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: June 8, 2016Publication date: July 12, 2018Inventors: Massimo S. Fiandaca, Howard J. Federoff
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Publication number: 20180149665Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: May 18, 2016Publication date: May 31, 2018Inventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone