Patents by Inventor Howard Urnovitz

Howard Urnovitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identifaction of cancer biomarkers by alignment of nucleic acid sequences
    Patent number: 11859251
    Abstract: CNA biomarkers can include nucleic acid sequences that are present in circulating nucleic acids obtained from circulatory systems of a population known to have cancer, but that are rarely present, if at all, in circulating nucleic acids obtained from circulatory systems of a control population. Information is received describing one or more sequences obtained from circulating nucleic acids in a population known to have cancer. Information is also received describing one or more sequences obtained from circulating nucleic acids in a control population. A cluster analysis within a predetermined portion of a genome uses the one or more sequences in the circulating nucleic acids obtained from the population known to have cancer and the one or more sequences in the circulating nucleic acids obtained from the control population. Information is generated identifying one or more biomarkers for the cancer based on a cluster search within results of the cluster analysis.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: January 2, 2024
    Assignee: CHRONIX BIOMEDICAL
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • PROSTATE CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20230087365
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: August 15, 2022
    Publication date: March 23, 2023
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • BREAST CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20220333213
    Abstract: The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: June 27, 2022
    Publication date: October 20, 2022
    Inventors: Ekkehard Schuetz, Julia Beck, Howard Urnovitz
  • Method of determining a numeric index of tumor-associated copy number changes of circulating nucleic acids associated with prostate cancer
    Patent number: 11414706
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: August 16, 2022
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • Breast cancer associated circulating nucleic acid biomarkers
    Patent number: 11377695
    Abstract: The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: July 5, 2022
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schuetz, Julia Beck, Howard Urnovitz
  • Analyzing circulating nucleic acids to identify a biomarker representative of cancer presented by a patient population
    Patent number: 10378064
    Abstract: CNA biomarkers can include nucleic acid sequences that are present in circulating nucleic acids obtained from circulatory systems of a population known to have cancer, but that are rarely present, if at all, in circulating nucleic acids obtained from circulatory systems of a control population. Information is received describing one or more sequences obtained from circulating nucleic acids in a population known to have cancer. Information is also received describing one or more sequences obtained from circulating nucleic acids in a control population. A cluster analysis within a predetermined portion of a genome uses the one or more sequences in the circulating nucleic acids obtained from the population known to have cancer and the one or more sequences in the circulating nucleic acids obtained from the control population. Information is generated identifying one or more biomarkers for the cancer based on a cluster search within results of the cluster analysis.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: August 13, 2019
    Assignee: CHRONIX BIOMEDICAL
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • PROSTATE CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20190185928
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Ekkehard SCHÜTZ, Julia BECK, Howard URNOVITZ
  • COLORECTAL CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20190136314
    Abstract: The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: June 13, 2018
    Publication date: May 9, 2019
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • BREAST CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20190078165
    Abstract: The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: August 13, 2018
    Publication date: March 14, 2019
    Inventors: Ekkehard Schuetz, Julia Beck, Howard Urnovitz
  • Prostate cancer associated circulating nucleic acid biomarkers
    Patent number: 10214775
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: February 26, 2019
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • Prostate Cancer Associated Circulating Nucleic Acid Biomarkers
    Publication number: 20180340233
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 29, 2018
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • Breast cancer associated circulating nucleic acid biomarkers
    Patent number: 10047397
    Abstract: The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: August 14, 2018
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schuetz, Julia Beck, Howard Urnovitz
  • Personalized biomarkers for cancer
    Patent number: 9909186
    Abstract: The invention provides methods and reagents for identifying personalized tumor biomarkers for a patient that has a solid tumor and methods of using such biomarkers to monitor patient responses to therapeutic treatments.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: March 6, 2018
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • PERSONALIZED BIOMARKERS FOR CANCER
    Publication number: 20160053328
    Abstract: The invention provides methods and reagents for identifying personalized tumor biomarkers for a patient that has a solid tumor and methods of using such biomarkers to monitor patient responses to therapeutic treatments.
    Type: Application
    Filed: December 13, 2013
    Publication date: February 25, 2016
    Applicant: CHRONIX BIOMEDICAL
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • PROSTATE CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20160002739
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 7, 2016
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • PROSTATE CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20150167069
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 18, 2015
    Applicant: CHRONIX BIOMEDICAL
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • COLORECTAL CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20140303008
    Abstract: The invention provides methods and reagents for diagnosing colorectal cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated. In some embodiments, the CNA biomarkers are polynucleotide fragments, e.g., DNA fragments, that are present at an elevated level in blood, e.g., in a serum or plasma sample, of a colorectal cancer patient in comparison to the level in blood, e.g., a serum or plasma sample, obtained from a normal individual who does not have colorectal cancer.
    Type: Application
    Filed: October 19, 2012
    Publication date: October 9, 2014
    Inventors: Ekkehard Schutz, Julia Beck, Howard Urnovitz
  • PROSTATE CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20130143214
    Abstract: The invention provides methods and reagents for diagnosing prostate cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: June 1, 2011
    Publication date: June 6, 2013
    Applicant: CHRONIX BIOMEDICAL
    Inventors: Ekkehard Schütz, Julia Beck, Howard Urnovitz
  • BREAST CANCER ASSOCIATED CIRCULATING NUCLEIC ACID BIOMARKERS
    Publication number: 20130116127
    Abstract: The invention provides methods and reagents for diagnosing breast cancer that are based on the detection of biomarkers in the circulating nucleic acids from a patient to be evaluated.
    Type: Application
    Filed: April 18, 2011
    Publication date: May 9, 2013
    Applicant: Chronix Biomedical
    Inventors: Ekkehard Schuetz, Julia Beck, Howard Urnovitz
  • Detection of nucleic acids to assess risk for bovine spongiform encephalopathy
    Patent number: 7368243
    Abstract: The present invention provides a method of detecting abnormal serum nucleic acid profiles to assess the risk of a transmissible spongiform encephalopathy, e.g., BSE.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: May 6, 2008
    Assignee: Chronix Biomedical
    Inventors: Ekkehard Schuetz, Leonid Iakoubov, Howard Urnovitz