Patents by Inventor Hsien-Chang Chang
Hsien-Chang Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200306755Abstract: A microfluidic chip includes a chip main body having a rotation center, a sample reservoir, a liquid groove, multiple reaction chambers, a first inlet channel and multiple second inlet channels, and a sealing membrane connected to the chip main body. The liquid groove has a feeding groove portion extending around the rotation center and the sample reservoir, and multiple metering groove portions extending away from the rotation center. The first inlet channel communicates the sample reservoir and the feeding groove portion. Each second inlet channel communicates a respective metering groove portion and a respective reaction chamber. The depth of the first inlet channel is smaller than those of the sample reservoir and the feeding groove portion. The depth of each second inlet channel is smaller than those of the respective metering groove portion, the respective reaction chamber and the first inlet channel.Type: ApplicationFiled: December 11, 2018Publication date: October 1, 2020Inventors: Hsien-Chang Chang, Wen-Chien Ko, Po-Lin Chen, Chung-Hsin Shih
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Patent number: 10751717Abstract: A microfluidic chip for collecting dielectric particles in a fluid sample to be tested includes an insulating substrate, a first interdigitated electrode, a second interdigitated electrode, and a dielectric layer. The dielectric layer is formed on the first and second interdigitated electrodes and is made from a semiconductive inorganic material having a dielectric constant of from 3.7 F/m to 80 F/m.Type: GrantFiled: June 4, 2018Date of Patent: August 25, 2020Assignee: National Cheng Kung UniversityInventors: Hsien-Chang Chang, Tien-Chun Tsai, Yen-Liang Cho, Zong-Zhan Wu, Peng-Ting Chen
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Publication number: 20190291108Abstract: A microfluidic chip for collecting dielectric particles in a fluid sample to be tested includes an insulating substrate, a first interdigitated electrode, a second interdigitated electrode, and a dielectric layer. The dielectric layer is formed on the first and second interdigitated electrodes and is made from a semiconductive inorganic material having a dielectric constant of from 3.7 F/m to 80 F/m.Type: ApplicationFiled: June 4, 2018Publication date: September 26, 2019Inventors: Hsien-Chang Chang, Tien-Chun Tsai, Yen-Liang Cho, Zong-Zhan Wu, Peng-Ting Chen
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Publication number: 20180149644Abstract: A biosensor includes a microstrip resonator, a collection actuator disposed adjacent to and spaced from the microstrip resonator, a port unit connected to a network analyzer and coupled with the microstrip resonator, and a substrate. The microstrip resonator includes a collecting portion provided with an analyte-specific reagent (ASR) for binding an analyte in a suspension. The collection actuator and the microstrip resonator are applied with alternating current (AC) electric energy to induce AC electrokinetic stirring in the suspension for actuating the binding. The microstrip resonator resonates at a resonant frequency associated with the binding so that the analyte can be quantified.Type: ApplicationFiled: December 30, 2016Publication date: May 31, 2018Inventors: Tung-Chieh YANG, Yu-Jie LAN, Tsung-Chih YU, Min-Hang WENG, Siang-Wen LAN, Ru-Yuan YANG, Tien-Chun TSAI, Hsien-Chang CHANG
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Publication number: 20170087562Abstract: A method for determining a treatment response of cells is provided with steps of providing a un-treated first sample and a treated second sample; applying an electric signal to the first sample and the second sample; obtaining a first motion parameter of the first sample and a second motion parameter of the second sample in the electric signal, respectively; and comparing the first motion parameter and the second motion parameter to determine whether there is a difference. The difference represents that the treatment response exists.Type: ApplicationFiled: September 23, 2016Publication date: March 30, 2017Inventors: Wei-lun HUANG, Wu-chou SU, Wei-pang CHUNG, Hai-wen CHEN, Hsien-chang CHANG
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Patent number: 9498784Abstract: A bio-chip adapted for separating and concentrating particles in a solution includes a chip body defining a receiving space therein for receiving the solution, an inner electrode disposed in the receiving space, an outer electrode unit disposed in the receiving space of the chip body and including a first outer electrode that is spaced apart from and surrounds the inner electrode, and a second outer electrode that is spaced apart from and surrounds the first outer electrode, and a power source electrically connected to the inner electrode, the first outer electrode, and the second outer electrode. A method for using the bio-chip to separating and concentrating the particles in the solution is also disclosed in the present invention.Type: GrantFiled: September 18, 2013Date of Patent: November 22, 2016Assignee: NATIONAL APPLIED RESEARCH LABORATORIESInventors: I-Fang Cheng, Fu-Liang Yang, Hsien-Chang Chang, Tzu-Ying Chen
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Patent number: 9096828Abstract: A method for separating charged particles in a liquid sample is disclosed. The method includes the steps of driving the liquid sample containing a plurality of charged particles to flow, forming a non-uniform electric field in the direction relative to the flow direction of the liquid sample by two electrodes, and aggregating the charged particles under the non-uniform electric field so as to separating the charged particles from the liquid sample. When the liquid sample flows through the non-uniform electric field, it doesn't contact to the electrodes. A device and its manufacturing method for separating charged particles in a liquid sample are also disclosed. Accordingly, the charged particles can be separated from the liquid sample easily and more effectively.Type: GrantFiled: March 15, 2013Date of Patent: August 4, 2015Assignee: NATIONAL CHENG KUNG UNIVERSITYInventors: Chen-Kuei Chung, Hsien-Chang Chang, Chia-Chern Chen, Cheng-Ting Li, Chia-Cheng Tu
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Publication number: 20150008127Abstract: An apparatus and method for measurement are disclosed. The apparatus and method separate solutes and suspended solids in a mixture using a dielectrophoretic force provided by an electrode and a conductive layer, and then perform quantitative or qualitative analysis on at least one of the solutes using the electrode or at least one of the suspended solids.Type: ApplicationFiled: July 3, 2014Publication date: January 8, 2015Inventors: Shu-Hsien Liao, Hsien Chang Chang
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Patent number: 8911605Abstract: A method of antibiotic susceptibility testing is disclosed, and includes the following steps: (A) providing a sample to be tested wherein the sample contains a microbe; (B) adding an antibiotic into the sample, wherein the antibiotic serves to inhibit cell wall synthesis; (C) checking the sample by dielectrophoresis and observing a shape change of the microbe; and (D) determining whether the microbe is susceptible to the antibiotic according to the shape change thereof. The present invention also discloses a method for determining a minimum inhibitory concentration of the antibiotic.Type: GrantFiled: May 17, 2012Date of Patent: December 16, 2014Assignee: National Cheng Kung UniversityInventors: Cheng-Che Chung, I-Fang Cheng, Wen-Horng Yang, Hsien-Chang Chang
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Publication number: 20140363827Abstract: An apparatus and a method for identifying the characteristics of a liquid sample due to capillary force are disclosed. The apparatus and the method spread the blood sample (which is obtained from the blood of a subject, or a mixture containing the blood of two different subjects) having an agglutination portion in a distribution space due to the capillary force.Type: ApplicationFiled: June 5, 2014Publication date: December 11, 2014Inventors: Shu-Hsien Liao, Chuan-Fa Chang, Hsien Chang Chang
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Patent number: 8808518Abstract: A method of microbial identification is disclosed. The method includes the steps of assembling dielectrophoretic particles modified with specific DNA probes on a surface thereof in a continuous fluid at a predetermined location in a microchannel to form a particle assembly by a negative dielectrophoretic force and a hydrodynamic force provided by the continuous fluid, narrowing gaps between the dielectrophoretic particles of the particle assembly to enhance the electric field in the gaps between the dielectrophoretic particles, injecting a fluid containing target DNAs of a target microbe into the microchannel at a predetermined flow rate to move the target DNAs toward the particle assembly and generating a positive dielectrophoretic force by the enhanced electric field to attract the target DNAs toward the dielectrophoretic particles of the particle assembly for hybridization with the DNA probes. The present invention also discloses a method of manipulation of nanoscale biomolecules.Type: GrantFiled: May 16, 2011Date of Patent: August 19, 2014Assignee: National Cheng Kung UniversityInventors: I-Fang Cheng, Hsien-Chang Chang, Cheng-Che Chung
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Publication number: 20140083855Abstract: A bio-chip adapted for separating and concentrating particles in a solution includes a chip body defining a receiving space therein for receiving the solution, an inner electrode disposed in the receiving space, an outer electrode unit disposed in the receiving space of the chip body and including a first outer electrode that is spaced apart from and surrounds the inner electrode, and a second outer electrode that is spaced apart from and surrounds the first outer electrode, and a power source electrically connected to the inner electrode, the first outer electrode, and the second outer electrode. A method for using the bio-chip to separating and concentrating the particles in the solution is also disclosed in the present invention.Type: ApplicationFiled: September 18, 2013Publication date: March 27, 2014Applicant: NATIONAL APPLIED RESEARCH LABORATORIESInventors: I-Fang Cheng, Fu-Liang Yang, Hsien-Chang Chang, Tzu-Ying Chen
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Patent number: 8614496Abstract: A method scales down an integrated circuit layout structure without substantially jeopardizing electronic characteristics of devices. First, a conductive line set includes a first conductive line and a second conductive line respectively passing through a first region and a second region. Second, a sizing-down operation is performed so that the first conductive line and the second conductive line respectively have a first region scaled-down line width, a first region scaled-down space and a first region scaled-down pitch in the first region as well as selectively have a second region original line width, a second region scaled-down space and a second region scaled-down pitch in the second region. The first region scaled-down line width and the second region original line width are substantially different from each other.Type: GrantFiled: January 11, 2012Date of Patent: December 24, 2013Assignee: United Microelectronics Corp.Inventor: Hsien-Chang Chang
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Publication number: 20130252228Abstract: A method for separating charged particles in a liquid sample is disclosed. The method includes the steps of driving the liquid sample containing a plurality of charged particles to flow, forming a non-uniform electric field in the direction relative to the flow direction of the liquid sample by two electrodes, and aggregating the charged particles under the non-uniform electric field so as to separating the charged particles from the liquid sample. When the liquid sample flows through the non-uniform electric field, it doesn't contact to the electrodes. A device and its manufacturing method for separating charged particles in a liquid sample are also disclosed, Accordingly, the charged particles can be separated from the liquid sample easily and more effectively.Type: ApplicationFiled: March 15, 2013Publication date: September 26, 2013Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: Chen-Kuei CHUNG, Hsien-Chang CHANG, Chia-Chern CHEN, Cheng-Ting LI, Chia-Cheng TU
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Publication number: 20130008793Abstract: A method of antibiotic susceptibility testing is disclosed, and includes the following steps: (A) providing a sample to be tested wherein the sample contains a microbe; (B) adding an antibiotic into the sample, wherein the antibiotic serves to inhibit cell wall synthesis; (C) checking the sample by dielectrophoresis and observing a shape change of the microbe; and (D) determining whether the microbe is susceptible to the antibiotic according to the shape change thereof. The present invention also discloses a method for determining a minimum inhibitory concentration of the antibiotic.Type: ApplicationFiled: May 17, 2012Publication date: January 10, 2013Applicant: National Cheng Kung UniversityInventors: Cheng-Che CHUNG, I-Fang CHENG, Wen-Horng YANG, Hsien-Chang CHANG
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Publication number: 20120292184Abstract: A method of microbial identification is disclosed. The method includes the steps of assembling dielectrophoretic particles modified with specific DNA probes on a surface thereof in a continuous fluid at a predetermined location in a microchannel to form a particle assembly by a negative dielectrophoretic force and a hydrodynamic force provided by the continuous fluid, narrowing gaps between the dielectrophoretic particles of the particle assembly to enhance the electric field in the gaps between the dielectrophoretic particles, injecting a fluid containing target DNAs of a target microbe into the microchannel at a predetermined flow rate to move the target DNAs toward the particle assembly and generating a positive dielectrophoretic force by the enhanced electric field to attract the target DNAs toward the dielectrophoretic particles of the particle assembly for hybridization with the DNA probes. The present invention also discloses a method of manipulation of nanoscale biomolecules.Type: ApplicationFiled: May 16, 2011Publication date: November 22, 2012Inventors: I-Fang CHENG, Hsien-Chang Chang, Cheng-Che Chung
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Publication number: 20120110542Abstract: A method scales down an integrated circuit layout structure without substantially jeopardizing electronic characteristics of devices. First, a conductive line set includes a first conductive line and a second conductive line respectively passing through a first region and a second region. Second, a sizing-down operation is performed so that the first conductive line and the second conductive line respectively have a first region scaled-down line width, a first region scaled-down space and a first region scaled-down pitch in the first region as well as selectively have a second region original line width, a second region scaled-down space and a second region scaled-down pitch in the second region. The first region scaled-down line width and the second region original line width are substantially different from each other.Type: ApplicationFiled: January 11, 2012Publication date: May 3, 2012Inventor: Hsien-Chang Chang
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Publication number: 20110244595Abstract: In a biomedical chip for blood coagulation tests and its manufacturing method and use, the biomedical chip comprises a substrate layer, a middle layer, and a cap layer, engaged and stacked with each other to define a microfluidic channel which has a first inlet and an outlet of the microfluidic channel respectively. A mixing interval is expanded outward from the microfluidic channel and interconnected to a second inlet, and has an interconnect portion and a capillary portion disposed between the substrate layer and the cap layer, and more specifically disposed around the periphery of the interconnect portion. With the biomedical chip having the substrate layer and cap layer made of a hydrophilic material, the blood and the reagent can be driven automatically by the capillary force of the microfluidic channel to flow and mix with each other, and the hydrophilic capillary force can be permanently maintained.Type: ApplicationFiled: March 28, 2011Publication date: October 6, 2011Applicant: National Cheng Kung UniversityInventors: Chen-Kuei Chung, Hsien-Chang Chang, Chia-Chern Chen, Yu-Sheng Chen, Cheng-Ting Li
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Publication number: 20100320558Abstract: A circuit layout structure includes a substrate including a first region and a second region, and a set of conductive lines including a first conductive line and a second conductive line which respectively pass through the first region and the second region, wherein a variable spacing lies between the first conductive line and the second conductive line and the first conductive line and the second conductive line selectively have a first region line width and a second region line width so that the first region line width and the second region line width are substantially different.Type: ApplicationFiled: June 18, 2009Publication date: December 23, 2010Inventor: Hsien-Chang Chang
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Patent number: 7344963Abstract: A semiconductor substrate having an integrated circuit die area surrounded by a scribe lane is provided. Within the integrated circuit die area, a first trench isolation region and a second trench isolation region are formed on the semiconductor substrate, wherein the first trench isolation region isolates a first active device region from a second active device region, and the second trench isolation region comprises a plurality of trench dummy features for reducing loading effect. A first gate electrode is formed on the first active device region and a second gate electrode on the second active device region. The first active device region is masked, while the second active device region and the trench dummy features are exposed. An ion implantation process is then performed to implant dopant species into the second active device region.Type: GrantFiled: April 20, 2006Date of Patent: March 18, 2008Assignee: United Microelectronics Corp.Inventors: Hsien-Chang Chang, Chia-Hsin Hou, Tsu-Yu Chu, Ko-Ting Chen