Patents by Inventor Hsin-Hsin Shen
Hsin-Hsin Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11298147Abstract: A minimally invasive surgical device includes a main body, a buffer assembly and a cutter bit. The main body includes an inner tube and an outer tube, wherein the inner tube is disposed in the outer tube. An end of the buffer assembly is connected to the inner tube. The cutter bit is connected to another end of the buffer assembly, wherein the cutter bit has a cutting portion. When the cutting portion is in contact with an object, the buffer assembly is adapted to enable the cutter bit to move relatively to the inner tube to decrease a cutting force between the cutting portion and the object, and is adapted to enable the cutting portion to be tilted with a surface of the object.Type: GrantFiled: March 1, 2018Date of Patent: April 12, 2022Assignee: Industrial Technology Research InstituteInventors: Ching-Chuan Jiang, Hsin-Hsin Shen, Ming-Chia Yang, Yun-Han Lin, Wei-Hong Chang
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Patent number: 11242516Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.Type: GrantFiled: September 21, 2018Date of Patent: February 8, 2022Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Pei-Yi Tsai, Chih-Hung Chen, Yi-Hung Lin, Chih-Chieh Huang, Hsin-Hsin Shen, Liang-Yin Ke, Chu-Huang Chen
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Publication number: 20210338414Abstract: A tissue repair device and a method for using the same are provided. The tissue repair device includes a body portion and at least one wire. The body portion includes an inner layer and an outer layer. The inner layer is close to a tissue, wherein the inner layer includes a hydrophilic structure, and the outer layer includes a hydrophobic structure. The wire is connected to the body portion to fix the body portion to the tissue.Type: ApplicationFiled: April 29, 2021Publication date: November 4, 2021Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chih-Chieh HUANG, Jeng-Liang KUO, Hui-Ting HUANG, Shiun-Yin CHANG, Meng-Hsueh LIN, Cheng-Yi WU, Lih-Tao HSU, Pei-I TSAI, Hsin-Hsin SHEN, Chih-Yu CHEN, Kuo-Yi YANG, Chun-Hsien MA
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Publication number: 20210340693Abstract: A method of preparing fiber includes blending bio-compatible ceramic powder and first polyester to form a ceramic powder composition, wherein the bio-compatible ceramic powder and the first polyester have a weight ratio of 10:90 to 60:40. The method further includes blending the ceramic powder composition and second polyester to form a composite material, wherein the ceramic powder composition and the second polyester have a weight ratio of 0.4:99.6 to 40:60. The method also spins the composite material to form a fiber. The first polyester has an intrinsic viscosity (IV) of 0.35 dL/g to 0.55 dL/g, and the second polyester has an intrinsic viscosity (IV) of 0.6 dL/g to 0.8 g/dL. The fiber can be woven to form an artificial ligament/tendon.Type: ApplicationFiled: April 29, 2021Publication date: November 4, 2021Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Shinn-Jen CHANG, Wesley Jen-Yang CHANG, Hsin-Hsin SHEN, Pei-Yi TSAI
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Patent number: 11154637Abstract: A biodegradable sealant includes: a polyethylene glycol derivative; a photoinitiator; and a solvent, wherein the content of the polyethylene glycol derivative is about 10-75 wt % in the biodegradable sealant. The polyethylene glycol derivative is obtained by a substitution reaction, and in the substitution reaction, the polyethylene glycol is modified with methacrylic anhydride.Type: GrantFiled: November 6, 2019Date of Patent: October 26, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hsin-Hsin Shen, Yu-Chi Wang, Sen-Lu Chen, Yu-Bing Liou, Jian-Wei Lin, Yi-Hsuan Lee, Ming-Chia Yang, Ying-Wen Shen, Wei-Lin Yu
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Publication number: 20210322625Abstract: The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.Type: ApplicationFiled: May 5, 2021Publication date: October 21, 2021Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hsin-Hsin SHEN, Ming-Chia YANG, Chia-Chi HO, Fang-Jie JANG, Che-Yu OU, Chi-Hsiang LIAO, Brian HSU, Tai-Horng YOUNG
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Patent number: 11141262Abstract: A bone implant includes at least one spiral and at least one pillar. The spiral surrounds an accommodating space. The pillar is disposed in the accommodating space and connected to the spiral. The pillar has at least one notch.Type: GrantFiled: December 21, 2018Date of Patent: October 12, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Pei-I Tsai, Hsin-Hsin Shen, Kuo-Yi Yang, Chih-Chieh Huang, Shih-Ping Lin, De-Yau Lin
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Publication number: 20210269765Abstract: A temperature-sensitive cell culture composition is provided. The temperature-sensitive cell culture composition includes a hydrogel, a cellulose, a gelatin and a collagen. Based on 1 part by weight of the collagen, a content of the hydrogel is between 0.03 parts by weight and 60 parts by weight, a content of the cellulose is between 150 parts by weight and 360 parts by weight, and a content of the gelatin is between 21 parts by weight and 12 parts by weight. In addition, a method for using the temperature-sensitive cell culture composition, a method for forming the temperature-sensitive cell culture composition, and a use of the temperature-sensitive cell culture composition are also provided.Type: ApplicationFiled: December 18, 2020Publication date: September 2, 2021Applicant: Industrial Technology Research InstituteInventors: Chia-Jung LU, Jing-En HUANG, Liang-Cheng SU, Hsin-Hsin SHEN, Yuchi WANG, Ying-Hsueh CHAO, Li-Hsin LIN, Hsiu-Hua HUANG
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Patent number: 11103446Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.Type: GrantFiled: December 31, 2019Date of Patent: August 31, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Yu-Bing Liou, Hsin-Yi Hsu, Ying-Wen Shen, Yun-Chung Teng, Yuchi Wang, Hsin-Hsin Shen
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Publication number: 20210206064Abstract: A three-dimensional printing apparatus having electrostatic auxiliary, including a printing platform, a feeding device, a nozzle, and a high voltage power supply, is provided. The feeding device and the nozzle are disposed above the printing platform. The nozzle is connected to the feeding device and is located between the feeding device and the printing platform. A distance between the nozzle and the printing platform is less than or equal to 1 cm. The high voltage power supply has an output end electrically connected to the nozzle and a ground end electrically connected to the printing platform.Type: ApplicationFiled: December 22, 2020Publication date: July 8, 2021Applicant: Industrial Technology Research InstituteInventors: Hsin-Hsin Shen, Chang-Chou Li, Li-Wen Lai, Yu-Bing Liou, Ying-Wen Shen
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Publication number: 20210196626Abstract: An ophthalmic drug delivery device and a method for fabricating the same are provided. The ophthalmic drug delivery device includes a shield element and a drug release element. The shield element has a light transmittance more than or equal to 80%. The drug release element is an annular body so that the drug release element surrounds the shield element. The drug release element is neutral and includes a cross-linked neutral collagen, a first hydrophilic biodegradable polymer and a drug. The shield element is acidic and includes a cross-linked acidic collagen and a second hydrophilic biodegradable polymer.Type: ApplicationFiled: December 31, 2019Publication date: July 1, 2021Applicant: Industrial Technology Research InstituteInventors: Yu-Bing LIOU, Hsin-Yi HSU, Ying-Wen SHEN, Yun-Chung TENG, Yuchi WANG, Hsin-Hsin SHEN
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Publication number: 20210196648Abstract: A drug-containing multilayer film provided. The drug-containing multilayer film includes: a drug-containing layer; and an anti-adhesion layer on a surface of the drug-containing layer. The drug-containing layer is composed of a first composition including a first polymer material and a drug, and the first polymer material includes at least one selected from the group consisting of: polylactic acid (PLA) and polyethylene glycol (PEG), and the weight ratio of the first polymer material to the drug is about 1:0.01-0.3. The anti-adhesion layer is composed of a second composition, and the second composition includes a second polymer material, and the second polymer material includes at least one selected from the group consisting of polylactic acid and polyethylene glycol.Type: ApplicationFiled: December 31, 2019Publication date: July 1, 2021Applicant: Industrial Technology Research InstituteInventors: Hsin-Hsin SHEN, Yuchi WANG, Li-Hsin LIN, Ming-Chia YANG, Hsiu-Hua HUANG, Liang-Cheng SU, Ying-Hsueh CHAO, Jing-En HUANG
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Patent number: 11027040Abstract: The present disclosure provides a method for manufacturing a porous film, including: preparing a polymer mixture solution, wherein the polymer mixture solution includes polycaprolactone and at least one hydrophobic polymer; adding solid particles as a dispersing agent to the polymer mixture solution and mixing the solid particles with the polymer mixture solution, wherein the amount of solid particles added is enough to convert the polymer mixture solution into a solid mixture; drying the solid mixture to form a film; and washing the film with a washing fluid to remove the solid particles from the film to form the porous film, wherein the weight ratio of the polycaprolactone to the at least one hydrophobic polymer is about 1:0.1-10, and wherein the weight ratio of the polycaprolactone and the at least one hydrophobic polymer to the solid particles is about 1:0.01-250.Type: GrantFiled: December 27, 2017Date of Patent: June 8, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hsin-Hsin Shen, Ming-Chia Yang, Chia-Chi Ho, Fang-Jie Jang, Che-Yu Ou, Chi-Hsiang Liao, Brian Hsu, Tai-Horng Young
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Publication number: 20210137699Abstract: The disclosure relates to a spinal intervertebral body fusion device including an adjustable spacer, a first and second pushing piece, and an operative piece. The adjustable spacer includes a first and second supporting plate. The first supporting plate portion is movably installed on the second supporting plate portion. The first and second supporting plate portions form a first and second opening respectively located at two opposite sides of the adjustable spacer. The first pushing piece located at the first opening and is partially clamped by the first and second supporting plate portions. The second pushing piece located at the second opening is partially clamped by the first and second supporting plate portions. The operative piece is movably disposed through the second pushing piece and screwed to the first pushing piece. The operative piece has an annular slot, and the second pushing piece is partially located in the annular slot.Type: ApplicationFiled: December 23, 2019Publication date: May 13, 2021Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Fang-Jie JANG, Pei-I TSAI, Chih-Chieh HUANG, De-Yau LIN, Wei-Lun FAN, Yi-Hung WEN, Kuo-Yi YANG, Hsin-Hsin SHEN
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Publication number: 20210137698Abstract: The disclosure relates to a vertebral body implant including a flexible main body and at least one pedicle screw joint. The flexible main body is an integrally formed single piece having at least one joint-accommodating hole and at least one opening connected to the at least one joint-accommodating hole. The pedicle screw joint is an integrally formed single piece movably accommodated in the at least one joint-accommodating hole.Type: ApplicationFiled: December 30, 2019Publication date: May 13, 2021Applicants: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, NATIONAL TAIWAN UNIVERSITY HOSPITALInventors: Fang-Jie JANG, Pei-I TSAI, De-Yau LIN, An-Li CHEN, Fon-Yih TSUANG, Chih-Chieh HUANG, Hsin-Hsin SHEN
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Patent number: 10973647Abstract: An artificial joint includes a first joint assembly and a second joint assembly. The first joint assembly is adapted to be connected to a first bone and has a first contacting surface, wherein the first contacting surface includes a first convex arc surface, a second convex arc surface, and a third convex arc surface. The second joint assembly is adapted to be connected to a second bone and has a second contacting surface, wherein the second contacting surface is in contact with the first contacting surface and includes a first concave arc surface, a second concave arc surface, and a third concave arc surface, and the first concave arc surface, the second concave arc surface, and the third concave arc surface respectively correspond to the first convex arc surface, the second convex arc surface, and the third convex arc surface.Type: GrantFiled: December 19, 2018Date of Patent: April 13, 2021Assignees: Industrial Technology Research Institute, National Taiwan University HospitalInventors: Pei-I Tsai, Hsin-Hsin Shen, Kuo-Yi Yang, De-Yau Lin, Yi-Hung Wen, Chih-Chieh Huang, Wei-Luan Fan, Pei-Yu Chen, Ching-Chi Hsu
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Publication number: 20210085606Abstract: The disclosure provides a use of hydrogel composition for alleviating degenerative joint and tendon tear. The hydrogel composition includes 100 parts by weight of therapeutic agent and 120-380 parts by weight of biodegradable copolymer, wherein the therapeutic agent comprises platelet-rich plasma (PRP), doxorubicin, transforming growth factor, bovine serum albumin, or a combination thereof. The biodegradable copolymer has a structure of Formula (I) or Formula (II): wherein A is a hydrophilic polyethylene glycol polymer; B is a hydrophobic polyester polymer; BOX is a bifunctional group monomer of 2, 2?-bis(2-oxazoline) used for coupling the blocks A-B or B-A-B; and n is 0 or an integer greater than 0.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Applicant: Industrial Technology Research InstituteInventors: Hsin-Hsin SHEN, Wen-Shiang CHEN, Chueh-Hung WU, Ming-Kuan SUN, Yu-Chi WANG, Sen-Lu CHEN, Wei-Lin YU, Lih-Tao HSU, Shih-Ping LIN
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Patent number: 10945736Abstract: A fixing device for suturing of blood vessels is provided, which includes a connecting rod, a first clamping member, a second clamping member, a first extension tube and a second extension tube. One end of the first clamping member is disposed on the connecting rod, and the other end of the first clamping member has a first clamping head. One end of the second clamping member is disposed on the connecting rod, and the other end of the second clamping member has a second clamping head. The first extension tube is disposed on an inner side of the first clamping head. The second extension tube is disposed on an inner side of the second clamping head and opposite to the first extension tube, wherein a relative position of the first extension tube and the second extension tube is adjustable.Type: GrantFiled: December 19, 2018Date of Patent: March 16, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Wan-Shiun Lou, Yuen-Yung Loh, Yung-Lung Liu, Wei-Lin Yu, Yen-Ling Wang, Hsin-Hsin Shen, Chia-Hao Chang
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Patent number: 10918474Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.Type: GrantFiled: September 5, 2018Date of Patent: February 16, 2021Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Yu-Bing Liou, Ming-Chia Yang, Hsin-Yi Hsu, Yun-Han Lin, Wei-Hong Chang, I-Jong Wang, Hsin-Hsin Shen
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Patent number: 10806584Abstract: An osteo-implant is provided, having a fixing segment and an implant end. The fixing segment is provided with a thread and at least one bone healing chamber. The bone healing chamber is located at a thread root of the thread. The bone healing chamber is a chamber inwardly depressed from a surface of the fixing segment. The fixing segment has a central axis. In the same section of the fixing segment, an area of a section, which is parallel to and passes through the central axis, of the at least one bone healing chamber closer to the implant end is smaller.Type: GrantFiled: December 29, 2016Date of Patent: October 20, 2020Assignees: Industrial Technology Research Institute, National Taiwan University HospitalInventors: Chih-Chieh Huang, Pei-I Tsai, Hsin-Hsin Shen, Yi-Hung Wen, Kuo-Yi Yang, Wei-Luan Fan, Jui-Sheng Sun, Nien-Ti Tsou