Patents by Inventor Hsin-Hsin Shen

Hsin-Hsin Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120045511
    Abstract: A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer; a surface antigen of hepatitis B virus (HBsAg); and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.
    Type: Application
    Filed: August 17, 2010
    Publication date: February 23, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Mi-Hua Tao, Ho-Yuan Chou, Hsin-Hsin Shen, Tsai-Yu Lin
  • Publication number: 20120040887
    Abstract: The disclosure provides a composition for the treatment of osteomyelitis and a method for preparing the same. The composition includes: 100 parts by weight of water; 0.06-0.1 parts by weight of an antibiotic; and 5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following: wherein, R1 is hydrogen, or —C(?O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually are integers greater than 0.
    Type: Application
    Filed: October 7, 2010
    Publication date: February 16, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Chin-Fu Chen, Hsin-Hsin Shen, Yu-Min Lee, I-Ming Chu, Kuo-Ti Peng
  • Publication number: 20120010139
    Abstract: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A??(Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B??Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2?-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 12, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shen-Hua Peng, Hsin-Hsin Shen, Liang-Yo Yang, Meng-Yow Hsieh, Pei-Shan Li, Wei-Lin Yu, Tsai-Yu Lin, Po-Liang Lai, Jui-Sheng Sun, Chih-Hung Chang, Yi-Hung Lin
  • Publication number: 20110251082
    Abstract: The present invention uses 2-dimensional differential gel electrophoresisgel (2D-DIGE) and mass spetrum techniques to identify breast cancer biomarkers in transformed breast cells. In summary, the present invention identifies numerous putative breast cancer markers from various stages of breast cancer. The results of the invention aids in developing proteins identified as useful diagnostic and therapeutic candidates on breast cancer research.
    Type: Application
    Filed: April 8, 2010
    Publication date: October 13, 2011
    Applicant: NATIONAL TSING HUA UNIVERSITY
    Inventors: Hong-Lin Chan, Hsiu-Chuan Chou, Tzu-Chia Lai, Yi-Wen Chen, Ping-Chiang Lyu, Tian -Ren Lee, Hsin-Tsu Chan, Hsin-Hsin Shen, Wei-Ta Lee, Szu-Ting Lin, Ying-Chieh Lu, Chieh-Lin Wu
  • Publication number: 20110147278
    Abstract: A magnetic separation device is provided, including a first magnetic field unit and a first separation unit disposed at a side of the first magnetic field unit. The first magnetic field unit includes a first magnetic yoke having opposite first and second surfaces, and a plurality of first magnets respectively disposed over the first and second surfaces, wherein the same magnetic poles of the plurality of first magnets face the first magnetic yoke. The first separation unit includes a body made of non-magnetic materials and a continuous piping disposed in the body, including at least one first section and at least one second section, wherein at least one second section is perpendicular to at least one first section, and at least one second section is adjacent to, and in parallel to a side of the first magnetic yoke not in contact with the plurality of first magnets.
    Type: Application
    Filed: April 15, 2010
    Publication date: June 23, 2011
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Mean-Jue Tung, Li-Kou Chen, Yu-Ting Huang, Hsin-Hsin Shen, Wei-Lin Yu, Yi-Shan Lin, Shinn-Zong Lin, Woei-Cherng Shyu, Hsiao-Jung Wang
  • Publication number: 20100166863
    Abstract: Biodegradable copolymer hydrogels are provided. The biodegradable copolymer hydrogels have a structure of Formula (I) or Formula (II) A-B—BOX—B-A??Formula (I) B-A-B—(BOX—B-A-B)n-BOX—B-A-B??Formula (II) , wherein, A comprises a hydrophilic polyethylene glycol polymer (A); B comprises a hydrophobic polyester polymer (B); BOX is bifunctional group monomer of 2,2?-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B; and n is an integer, equal to or greater than 0.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 1, 2010
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Hsin-Hsin SHEN, Chin-Fu CHEN, Meng-Yow HSIEH, Miao-Tzu CHEN, Wen-Fu LEE
  • Patent number: 7714146
    Abstract: The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R1, R2 and R3 represents a moiety of formula (II), each of A1 and A2 independently is nitrogen, oxygen or sulfur, each of the others of R1, R2, R3, R1, R5, R6, R7, R8, R9, R10, R11, R12, R13, and R14 is as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 11, 2010
    Assignee: Industrial Technology Research Institute
    Inventors: On Lee, Chrong-Shiong Hwang, Chih-Hung Chen, Yuan-Jang Tsai, Chih-Peng Liu, Ching-Huai Ko, Hsin-Hsin Shen, Ling-Mei Wang, Kuei-Tai Lai, Ying-Chu Shih, Ting-Shou Chen, Yen-Chun Chen, Lain-Tze Lee
  • Publication number: 20090280200
    Abstract: An herbal extract which induces immune cells to produce interferon and activates Toll-like receptors and a preparation method thereof are provided. The herbal extract is extracted from an effective amount of raw material including Glycyrrhizae Radix, Bupleuri Radix, Scutellariae Radix, Schisandrae Fructus and Paeoniae Rubra Radix. Glycyrrhizae Radix, Bupleuri Radix, Scutellariae Radix, Schisandrae Fructus and Paeoniae Rubra Radix have a weight ratio of 1-5:1-5:1-5:1-3:1-3.
    Type: Application
    Filed: June 30, 2008
    Publication date: November 12, 2009
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: I Horng PAN, Lain-Tze LEE, Chih-Lung CHEN, Hsin-Jan YAO, Chu-Hsun LU, Chen Hsuan LIN, Ya-Yan YANG, Hsin-Hsin SHEN, Ming-Feng CHEN
  • Publication number: 20080125590
    Abstract: An azulene compound is provided. The azulene compound has formula (I) shown below. Each variable in formula (I) is defined in the specification. One of R1, R2, R3, R4, R5, R6, R7, and R8 in formula (I) is a moiety of formula (II). The compound can be used to treat cancer.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 29, 2008
    Applicant: Industrial Technology Research Institute
    Inventors: On Lee, Chrong-Shiong Hwang, Chih-Hung Chen, Yuan-Jang Tsai, Chih Peng Liu, Ching-Huai Ko, Hsin-Hsin Shen, Ling-Mei Wang, Kuei-Tai Lai, Ying-Chu Shih, Ting-Shou Chen, Yen-Chun Chen, Lain-Tze Lee
  • Publication number: 20060251698
    Abstract: The present invention relates to a device for directing and accelerating the growth of neuronal axon or neurite. The invention accelerates the growth speed of axon of nerve cells by using a substrate configured with a discontinuous micropattern of neuronal path-finding molecules or material thereon. The invention can reduce the connection or regeneration time of neural network. The present invention also discloses a micro-contact printing method for producing the device.
    Type: Application
    Filed: October 11, 2005
    Publication date: November 9, 2006
    Applicant: Industrial Technology Research Institute
    Inventors: Hsin-Hsin Shen, Wan-Shiun Lou, Chi-Hung Lin, Hong-Wen Liu
  • Publication number: 20050142660
    Abstract: The invention provides a conditioned medium that enhances the survival and/or proliferation of Schwann cells in cell culture, and a cell line useful for production of such medium. The cell line used in the invention is a differentiated NTera2/D1 (NT2) cell line.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 30, 2005
    Applicant: Industrial Technology Research Institute
    Inventors: Wan-Shiun Lou, Yu-Hua Chen, Pei-Ching Chang, Hsin-Hsin Shen
  • Publication number: 20030176876
    Abstract: A multi-channel bioresorbable nerve regeneration conduit and a process for preparing the conduit. The multi-channel bioresorbable nerve regeneration conduit includes a hollow round tube of a porous bioresorbable polymer and a multi-channel filler in the round tube. The multi-channel filler is a porous bioresorbable polymer film with an uneven surface and is single layer, multiple layer, in a folded form, or wound into a spiral shape.
    Type: Application
    Filed: June 4, 2002
    Publication date: September 18, 2003
    Inventors: Jui-Hsiang Chen, Jean-Dean Yang, Hsin-Hsin Shen, Yu-Lin Hsieh, Bin-Hong Tsai, Chiung-Lin Yang, Mei-Jun Liu