Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A high anti-interference microsystem based on System In Package (SIP) for a power grid is provided. The high anti-interference microsystem comprises a ceramic cavity, a ceramic substrate, a magnetic cover plate, a digital signal processing circuit, an analog signal conditioning circuit and a shield, wherein the ceramic cavity supports the ceramic substrate, the magnetic cover plate is in sealed contact with the ceramic cavity, and the ceramic substrate is arranged in a cavity formed by the ceramic cavity and the magnetic cover plate; a sealed shell of the microsystem based on SIP is composed of the magnetic cover plate and the ceramic cavity; the digital signal processing circuit and the analog signal conditioning circuit are arranged on the ceramic substrate and respectively process received signals to be processed; the shield covers an outer side of the sealed shell and is used for shielding external magnetic field interference.

Abstract: In the spark plug heat rating measurement method and system based on spark discharge current active heating, the spark plug is installed in a constant-temperature water jacket cooling chamber with a specific torque. A constant spark discharge current control module is connected to the high-voltage terminal of the spark plug, to provide real-time controlled discharge current to heat up the high-voltage central electrode of the spark plug. During the spark discharge process, the temperature change of the high-voltage central electrode and the surrounding ceramic insulator are measured by a temperature detection module and used to determine the heat rating of the spark plug. By real time adjusting the discharge current level of the spark plug, or providing a same amount of spark energy to the spark gap, the heat ratings of spark plugs with different ceramic insulation structures can be evaluated through the temperature changes during discharge or after discharge.

Abstract: A random access method, a base station, and a user equipment (UE) are disclosed. The random access method includes: transmitting a first message for random access for the UE, the first message including a preamble message and a signal message; receiving a second message and a fourth message for random access for the UE at a time and determining random access for the UE is successful upon receiving the second message and the fourth message; and upon reception of a second message configured to request the UE to transmit the signal message, transmitting a third message comprising the signal message, receiving the fourth message in response to the third message, and determining random access for the UE is successful upon receiving the fourth message.

Abstract: A random access method, a base station, and a user equipment (UE) are disclosed. The random access method includes: transmitting a first message for random access for the UE, the first message including a preamble message and a signal message; receiving a second message and a fourth message for random access for the UE at a time and determining random access for the UE is successful upon receiving the second message and the fourth message; and upon reception of a second message configured to request the UE to transmit the signal message, transmitting a third message comprising the signal message, receiving the fourth message in response to the third message, and determining random access for the UE is successful upon receiving the fourth message.

Abstract: A random access method, a base station, an UE and a device with a storage function are disclosed. The random access method includes: the base station receiving a first message transmitted by the UE, the first message including a preamble message and a signal message; decoding the preamble message and the signal message respectively; if the decoding of preamble message is succeeded, but the decoding of signal message fails, the base station transmits a second message to the UE, and storing the signal message of decoding failure, the second message configured to request the UE to retransmit the signal message; receiving the third message transmitted by the UE, the third message including the signal message; using a chase combine mechanism to decode the third message according to the stored signal message in the first message. The present disclosure save time and improve the efficiency of random access.

Abstract: A random access method, a base station, an UE and a device with a storage function are disclosed. The random access method includes: the base station receiving a first message transmitted by the UE, the first message including a preamble message and a signal message; decoding the preamble message and the signal message respectively; if the decoding of preamble message is succeeded, but the decoding of signal message fails, the base station transmits a second message to the UE, and storing the signal message of decoding failure, the second message configured to request the UE to retransmit the signal message; receiving the third message transmitted by the UE, the third message including the signal message; using a chase combine mechanism to decode the third message according to the stored signal message in the first message. The present disclosure save time and improve the efficiency of random access.

Abstract: A silicon photomultiplier (SiPM) based detection system includes a plurality of scintillators, SiPMs, a front end circuit, adjustment circuits, and an energy and position processing unit. The SiPMs have a non-linear response to energy deposition corresponding to radiation detection. The adjustment circuit is configured to receive an analog signal from SiPMs, and to provide an adjusted analog signal, which is configured to simulate a signal corresponding to a linear response. The energy and position processing unit utilizes the adjusted signal to provide energy and position information of detected events in the detector block.

Abstract: The present invention belongs to the field of bio-pharmaceutical material preparation technology, and relates to a preparation method of albumin nanoparticle carrier entrapping taxane-typed drug. This preparation method rapidly forms nanoparticle solution of albumin entrapping taxane-typed drug under room temperature by adding solvent as the medium. Next, by the second time of freeze-drying, stable powder of albumin nanoparticles entrapping taxane-typed drug is obtained. The final freeze-dried powder only includes two components: albumin and taxane-typed drug. The particles are in regular spherical shape, and the diameter of particle is less than 100 nm. The present invention has high drug loading ratio and entrapment efficiency. The experiment of releasing in vitro shows that the present invention has a good slow-release effect. Taxane-typed drug nanoparticles provided by the present invention improves the safety and compliance of this type of reagent.

Abstract: The present invention discloses a cellular-network-assisted wireless local area network (WLAN) channel switch announcement method, including the following steps: before a wireless network access point (AP) performs channel switching, delivering channel switch announcement signaling to correlated user equipment in a broadcast manner, and sending channel switch announcement request signaling to a cellular network base station that also serves the user equipment; after the cellular network base station receives the channel switch announcement request signaling, sending the channel switch announcement signaling to user equipment in an idle mode by using a cellular link air interface; and performing, by the WLAN AP, channel switching within a predetermined time, and following, by user equipment that directly acquires channel switch information by receiving the channel switch announcement signaling and user equipment that acquires channel switch information by using the cellular network base station, the WLAN AP an

Abstract: The present approach relates to the use of machine-learning in convolution kernel design for scatter correction. In one aspect, a neural network is trained to replace or improve the convolution kernel used for scatter correction. The training data set may be generated probabilistically so that actual measurements are not employed.

Abstract: A hybrid monitoring-sleeping method of wireless sensor and the wireless sensor are provided by the present invention, during N (N=N1+N2) monitoring-sleeping period, the wireless sensor monitors with the first monitoring duration, the wake-up data packet transmitted by the data acquisitor or the mobile terminal in the N1 monitoring-sleeping periods, and the wireless sensor monitors with the second monitoring duration, the wake-up data packet transmitted by the mobile terminal in the remaining N2 monitoring-sleeping periods. The first monitoring duration is longer than the second monitoring duration, N1 is less than or equal to N2, and the N1 first monitoring duration and the N2 second monitoring duration are alternatively distributed. Compared with the single monitoring duration used in the prior art, the total monitoring duration of the N monitoring-sleeping periods is reduced, as a result, the monitoring power consumption of the wireless sensor is also reduced.

Abstract: A silicon photomultiplier (SiPM) based detection system includes a plurality of scintillators, SiPMs, a front end circuit, adjustment circuits, and an energy and position processing unit. The SiPMs have a non-linear response to energy deposition corresponding to radiation detection. The adjustment circuit is configured to receive an analog signal from SiPMs, and to provide an adjusted analog signal, which is configured to simulate a signal corresponding to a linear response. The energy and position processing unit utilizes the adjusted signal to provide energy and position information of detected events in the detector block.

Abstract: The present invention discloses a cellular-network-assisted wireless local area network (WLAN) channel switch announcement method, including the following steps: before a wireless network access point (AP) performs channel switching, delivering channel switch announcement signaling to correlated user equipment in a broadcast manner, and sending channel switch announcement request signaling to a cellular network base station that also serves the user equipment; after the cellular network base station receives the channel switch announcement request signaling, sending the channel switch announcement signaling to user equipment in an idle mode by using a cellular link air interface; and performing, by the WLAN AP, channel switching within a predetermined time, and following, by user equipment that directly acquires channel switch information by receiving the channel switch announcement signaling and user equipment that acquires channel switch information by using the cellular network base station, the WLAN AP an

Abstract: The present invention belongs to the field of bio-pharmaceutical material preparation technology, and relates to a preparation method of albumin nanoparticle carrier entrapping taxane-typed drug. This preparation method rapidly forms nanoparticle solution of albumin entrapping taxane-typed drug under room temperature by adding solvent as the medium. Next, by the second time of freeze-drying, stable powder of albumin nanoparticles entrapping taxane-typed drug is obtained. The final freeze-dried powder only includes two components: albumin and taxane-typed drug. The particles are in regular spherical shape, and the diameter of particle is less than 100 nm. The present invention has high drug loading ratio and entrapment efficiency. The experiment of releasing in vitro shows that the present invention has a good slow-release effect. Taxane-typed drug nanoparticles provided by the present invention improves the safety and compliance of this type of reagent.

Abstract: A SiPM readout circuit includes a front-end circuit having amplifiers coupled to SiPM analog outputs, pixel readout channels coupled to amplifiers provide a timing signal representing gamma ray photon detection in individual SiPM, a block timing channel that creates a summed signal from all SiPMs, and generates a block timing signal and a validation signal, an energy channel that generates a summed energy signal and a two-dimensional position of the gamma ray photon detection in the block, and a control logic/processing circuit that performs a time stamp estimation method. Methods of determining the radiation event timing and a non-transitory computer-readable medium containing computer-readable instructions to implement the methods are disclosed.

Abstract: A SiPM readout circuit includes a front-end circuit having amplifiers coupled to SiPM analog outputs, pixel readout channels coupled to amplifiers provide a timing signal representing gamma ray photon detection in individual SiPM, a block timing channel that creates a summed signal from all SiPMs, and generates a block timing signal and a validation signal, an energy channel that generates a summed energy signal and a two-dimensional position of the gamma ray photon detection in the block, and a control logic/processing circuit that performs a time stamp estimation method. Methods of determining the radiation event timing and a non-transitory computer-readable medium containing computer-readable instructions to implement the methods are disclosed.

Abstract: Methods and systems are provided for medical imaging systems. In one embodiment, a method comprises estimating an external scatter contamination in emission data based on an estimated emission activity originating from anatomies outside a field-of-view (FOV) of a scanner, the anatomies identified based on an image segmentation analysis performed on an image generated in the imaging system, the image generated prior to acquiring the emission data. In this way, a scatter correction applied to the emission data may include both scatter originating within the FOV and outside the FOV, and hence may be more accurate.

Abstract: Embodiments of the invention are utilized to improve the timing performance of SiPM based PET detectors with light-sharing configuration. The universal readout design utilizes adaptive group readout to process noisy and slow signals generated by SiPM devices, and provides enhanced timing capabilities with simplified readout electronics.

Abstract: A system and method for estimating image intensity bias and segmentation tissues is presented. The system and method includes obtaining a first image data set and at least a second image data set, wherein the first and second image data sets are representative of an anatomical region in a subject of interest. Furthermore, the system and method includes generating a baseline bias map by processing the first image data set. The system and method also includes determining a baseline body mask by processing the second image data set. In addition, the system and method includes estimating a bias map corresponding to a sub-region in the anatomical region based on the baseline body mask. Moreover, the system and method includes segmenting one or more tissues in the anatomical region based on the bias map.